Results 31 to 40 of about 246,399 (165)

Interactions of complement proteins C1q and factor H with lipid A and Escherichia coli: further evidence that factor H regulates the classical complement pathway [PDF]

Protein & Cell, 2011
Lee Aun Tan, Andrew Chung Yang, Uday Kishore, Robert B. Sim   +3 more
openalex   +2 more sources

The classical pathway triggers pathogenic complement activation in membranous nephropathy

Nature Communications, 2023
Membranous nephropathy (MN) is an antibody-mediated autoimmune disease characterized by glomerular immune complexes containing complement components. However, both the initiation pathways and the pathogenic significance of complement activation in MN are
Larissa Seifert, G. Zahner, C. Meyer-Schwesinger, Naemi C. Hickstein, S. Dehde, S. Wulf, Sarah M. S. Köllner, R. Lucas, Dominik Kylies, Sarah Froembling, Stephanie Zielinski, O. Kretz, A. Borodovsky, S. Biniaminov, Yan-yan Wang, Hong Cheng, F. Koch-Nolte, P. Zipfel, H. Hopfer, Victor G. Puelles, U. Panzer, T. Huber, T. Wiech, N. Tomas   +23 more
semanticscholar   +1 more source

Human complement factor H. Two factor H proteins are derived from alternatively spliced transcripts [PDF]

, 1991
The human complement factor H is an important component in the control of the alternative pathway of complement activation. We have previously shown that at least three factor H homologous mRNA species of 4.3 kb, 1.8 kb and 1.4 kb in length are ...
Alsenz, Alsenz, Aruffo, Chirgwin, Church, Conrad, Day, Feinberg, Fontaine, Kristensen, Laemmli, Maniatis, McAleer, Misasi, Pangburn, Ripoche, Schulz, Schulz, Schwaeble, Seed, Sim, Towbin, Whaley, Whaley   +23 more
core   +1 more source

Functional and Structural Characterization of a Potent C1q Inhibitor Targeting the Classical Pathway of the Complement System

Frontiers in Immunology, 2020
The classical pathway of complement is important for protection against pathogens and in maintaining tissue homeostasis, but excessive or aberrant activation is directly linked to numerous pathologies.
N. S. Laursen, D. Pedersen, H. Gytz, A. Zarantonello, Jens Magnus Bernth Jensen, A. Hansen, S. Thiel, G. Andersen   +7 more
semanticscholar   +1 more source

Innate immunity and neuroinflammation [PDF]

, 2013
Copyright © 2013 Abhishek Shastri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...
Bonifati, DM, Kishore, U, Shastri, A
core   +3 more sources

Gain-of-Function Mutations R249C and S250C in Complement C2 Protein Increase C3 Deposition in the Presence of C-Reactive Protein [PDF]

, 2021
The impairment of the alternative complement pathway contributes to rare kidney diseases such as atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G).
Alonso, Eugenia Castellote, Arjona, Emilia, Fenollosa Segarra, María Ángeles, Jongerius, Ilse, Kowalska, Daria, Kuźniewska, Alicja, Okrój, Marcin, Ołdziej, Stanisław, Rodriguez de Córdoba, Santiago, Satchell, Simon, Skrobińska, Anna, Spaapen, Robbert, Stasiłojć, Grzegorz, Thiel, Marcel, Urban, Aleksandra   +14 more
core   +2 more sources

A Systematic Investigation on Complement Pathway Activation in Diabetic Retinopathy

Frontiers in Immunology, 2020
The complement system plays a crucial role in retinal homeostasis. While the proteomic analysis of ocular tissues in diabetic retinopathy (DR) has shown the deposition of complement proteins, their exact role in the pathogenesis of DR is yet unclear.
Shahna Shahulhameed, Sushma Vishwakarma, J. Chhablani, Mudit Tyagi, R. Pappuru, Saumya Jakati, S. Chakrabarti, I. Kaur   +7 more
semanticscholar   +1 more source

Ischemia and reperfusion injury in kidney transplantation : relevant mechanisms in injury and repair [PDF]

, 2020
Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation.
Berger, Stefan P., Leuvenink, Henri G. D., Nieuwenhuijs-Moeke, Gertrude J., Pischke, Soren E., Ploeg, Rutger J., Pol, Robert A., Sanders, Jan Stephan F., Struys, Michel   +7 more
core   +2 more sources

Effect of anticomplement agent K-76 COOH in hamster-to-rat and guinea pig- to-rat xenotransplantation [PDF]

, 1995
In normal rats, the xenobiotic K76 inhibited the C5 and probably the C2 and C3 steps of complement and effectively depressed classical complement pathway activity, alternative complement pathway activity, and the C3 complement component during and well ...
Adachi, Anthony J. Demetris, Cochrane, Gewurz, Hasan, Hideaki Miyazawa, Hong, Iida, Kissmeyer-Nielsen, Kitano, Kitano, Leventhal, Minoru Nomoto, Mitsuko Tanaka, Miyagawa, Miyagawa, Miyazaki, Miyazaki, Miyazawa, Murase, Nelson, Noriko Murase, Ono, Perper, Pruitt, Pruitt, Qing Ye, Rafael Manez, Satoru Todo, Soares, Starzl, Starzl, Starzl, Starzl, Tanaka, Thomas E. Starzl, Valdivia, Van den Bogaerde, Wasei Miyazaki, Xia, Yamamoto, Yoichi Toyama   +41 more
core   +2 more sources

Membranoproliferative glomerulonephritis in patients with chronic venous catheters: a case report and literature review. [PDF]

, 2014
Chronic indwelling catheters have been reported to be associated with membranoproliferative glomerulonephritis (MPGN) via the activation of the classical complement pathway in association with bacterial infections such as coagulase negative ...
Nast, Cynthia C, Pham, Phuong-Chi T, Pham, Phuong-Thu T, Sy, John   +3 more
core   +2 more sources