Results 121 to 130 of about 4,411,154 (387)

Simulation of guiding of multiply charged projectiles through insulating capillaries

, 2005
Recent experiments have demonstrated that highly charged ions can be guided through insulating nanocapillaries along the direction of the capillary axis for a surprisingly wide range of injection angles.
Aumayr, Burgdörfer, C. Lemell, Frank, Frenkel, J. Burgdörfer, K. Schiessl, Lilly, Lilly, Morishita, Ninomya, O’Dwyer, Schug, Stolterfoht, Stolterfoht, Stolterfoht, Tökési, W. Palfinger, Wirtz   +18 more
core   +1 more source

Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes

Nature Communications, 2016
DNA double-strand breaks (DSBs) leading to loss of nucleotides in the transcribed region can be lethal. Classical non-homologous end-joining (C-NHEJ) is the dominant pathway for DSB repair (DSBR) in adult mammalian cells.
Anirban Chakraborty, N. Tapryal, T. Venkova, N. Horikoshi, R. Pandita, A. Sarker, P. Sarkar, T. Pandita, T. Hazra   +8 more
semanticscholar   +1 more source

Classics in Neuroimaging: Imaging the Dopaminergic Pathway with PET [PDF]

ACS Chemical Neuroscience, 2017
The success of positron emission tomography (PET) for observing molecular processes underlying brain function and disease is underpinned by radiotracer chemistry. From the earliest applications of PET to measure dopamine synthesis capacity and the abundance of neuroreceptors and transporters, to the more recent topic of dynamic neurochemical imaging ...
Jacob M. Hooker, Neil Vasdev, Meghna Kanthan, Paul Cumming, Paul Cumming   +4 more
openaire   +3 more sources

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

Molecular Oncology, EarlyView.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu, Fenglin Shen, Yang Liu, Ziqing Zhong, Yongling Chen, Zhiyuan Xia, Cuiju Mo, Hongxiu Yu   +7 more
wiley   +1 more source

Fingerprints of slingshot non-sequential double ionization on two-electron probability distributions [PDF]

, 2019
We study double ionization of He driven by a near-single-cycle laser pulse at low intensities at 400 nm. Using a three-dimensional semiclassical model, we identify the pathways that prevail non-sequential double ionization (NSDI).
Emmanouilidou, Agapi, Katsoulis, Georgios Petros   +1 more
core   +2 more sources

Overt and covert paths for sound in the auditory system of mammals. 2 [PDF]

arXiv, 2022
Current scientific consensus holds that sound is transmitted, solely mechanically, from the tympanum to the cochlea via ossicles. However this theory does not explain the hearing extreme quality regarding high frequencies in mammals. So, we propose a bioelectronic pathway (the covert path) that is complementary to the overt path.
arxiv  

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Use of C4d as a diagnostic tool to classify membranoproliferative glomerulonephritis

Nefrología, 2017
Background: Membranoproliferative glomerulonephritis (MPGN type I, II and III) was reclassified in 2013 as MPGN and C3 glomerulopathy (C3G) based on the complement system activation mechanism.
Nirupama Gupta, Dara N. Wakefield, William L. Clapp, Eduardo H. Garin   +3 more
doaj   +3 more sources

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Serum concentrations of complement C3 and C4 in dogs with idiopathic epilepsy

Journal of Veterinary Internal Medicine
Background High concentrations of complement factors are presented in serum of animal epilepsy models and human patients with epilepsy. Objectives To determine whether complement dysregulation occurs in dogs with idiopathic epilepsy (IE).
Seonggweon Kang, Yoonhoi Koo, Taesik Yun, Yeon Chae, Dohee Lee, Hakhyun Kim, Mhan‐Pyo Yang, Byeong‐Teck Kang   +7 more
doaj   +1 more source