Results 291 to 300 of about 637,830 (333)

Classics in Neuroimaging: Imaging the Endocannabinoid Pathway with PET

ACS Chemical Neuroscience, 2020
This Viewpoint aims to highlight positron emission tomography (PET) research studies that have shaped our understanding of the endocannabinoid system (ECS) through radiopharmaceutical targeting of cannabinoid receptors 1 and 2 (CB1 and CB2), and the enzyme fatty acid amide hydrolase (FAAH), in several brain health illnesses including addiction ...
Hsiao-Ying Wey, Steven H. Liang, Cassis Varlow, Cassis Varlow, Neil Vasdev, Isabelle Boileau, Isabelle Boileau   +6 more
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complement classical and lectin pathways

2010
The classical and lectin pathways of complement are major recognition systems of innate immunity that are found in mammals and other animal species. By means of several multimolecular proteases – C1, the mannan-binding lectin (MBL)–MBL-associated serine protease 2 (MBL–MASP-2) and the ficolin–MASP-2 complexes – each comprising a recognition protein and
Thielens, Nicole, Gaboriaud, Christine, Thiel, Steffen   +2 more
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Classical and unconventional pathways of vesicular release in microglia

Glia, 2013
Emerging evidence indicates that activation of microglia, the immune cells of the brain, is strictly associated to both secretion of soluble molecules and release of extracellular membrane vesicles (EMVs) into the pericellular space. Through these processes, microglia heavily influence brain cell functions, either propagating inflammation and causing ...
Ilaria Prada, Roberto Furlan, Michela Matteoli, Claudia Verderio   +3 more
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The non-classical functions of the classical complement pathway recognition subcomponent C1q

Immunology Letters, 2010
C1q, the ligand recognition subcomponent of the classical complement pathway has steadily been gaining recognition as a bridge between innate and adaptive immunity. C1q has been shown to be involved in the modulation of various immune cells (such as dendritic cells, platelets, microglia cells and lymphocytes), clearance of apoptotic cells, a range of ...
Uday Kishore, Annapurna Nayak, Anthony G. Tsolaki, Janez Ferluga   +3 more
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Classical complement pathway factor alterations in narcolepsy

Acta Neuropsychiatrica, 2022
AbstractObjective:Narcolepsy is a chronic sleep disorder long hypothesised to be an autoimmune disease. Complement-mediated immune mechanisms have not been investigated in detail in narcolepsy. Our aim was to establish the significance of classical pathway activation in narcolepsy.Methods:Sera of 42 narcolepsy patients and 26 healthy controls were ...
Hande Yüceer, Duygu Gezen Ak, Gülçin Benbir Şenel, Erdinç Dursun, Vuslat Yılmaz, Derya Karadeniz, Erdem Tüzün, Cem İsmail Küçükali   +7 more
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A novel ELISA for the evaluation of the classical pathway of complement

Journal of Immunological Methods, 1998
Assessment of the overall function of the classical pathway of complement is traditionally performed by the hemolytic titration assay CH50. In the present study, we established a novel method for the quantitation of complement activity by measuring the deposition of C1q, C4, C3 and C9 on solid-phase IgM by an enzyme-linked immunosorbent assay (ELISA ...
Otto Götze, A Wittig, Jörg Zwirner, E Kremmer   +3 more
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Interaction of fucoidan with the complement proteins of the classical pathway

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2003
Fucoidan inhibits complement by mechanisms that so far remain to be unraveled, and the objective of this work was to delineate the mode of inhibition by this sulfated polysaccharide. For that purpose, low molecular weight fractions of algal (Ascophyllum nodosum) fucoidan containing the disaccharide unit [-->3)-alpha-L-Fuc(2SO3(-))-(1-->4)-alpha-L-Fuc(2,
Tissot, B., Montdargent, B., Chevolot, L., Varenne, A., Descroix, S., Gareil, P., Daniel, Régis   +6 more
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Classical Signaling Pathways

2014
In this chapter, I introduce a number of important aspects of intracellular signaling pathways related to the protection and degeneration in cells, especially neurons, under physiological and pathological conditions. Extracellular stimuli activate intracellular signaling pathways by receptor- and/or channel-mediated manner or simple diffusion across ...
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Targetable molecular pathways in classical Hodgkin's lymphoma

Expert Opinion on Investigational Drugs, 2011
most patients with classical Hodgkin's lymphoma (cHL) are cured by stage-adapted multimodal regimens. However, some will suffer from refractory disease or experience a relapse. Furthermore, late toxicity due to aggressive chemotherapy and/or radiotherapy has become an increasing problem in long-term survivors.
Adams, Heiner, Obermann, Ellen C., Dirnhofer, Stephan, Tzankov, Alexandar   +3 more
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Activation of the classical complement pathway by BioRex-70

Immunology Letters, 1987
The cation exchange resin BioRex-70 was able to activate the classical complement pathway in human serum at 37 degrees C over the resin concentration range 0-5% (v/v). Using zymosan-treated human serum, it was found that the activation proceeded as far as complement protein C3.
S.B. Easterbrook-Smith, R.J. Vandenberg
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