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Interaction of fucoidan with the proteins of the complement classical pathway
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2003Fucoidan inhibits complement by mechanisms that so far remain to be unraveled, and the objective of this work was to delineate the mode of inhibition by this sulfated polysaccharide. For that purpose, low molecular weight fractions of algal (Ascophyllum nodosum) fucoidan containing the disaccharide unit [-->3)-alpha-L-Fuc(2SO3(-))-(1-->4)-alpha-L-Fuc(2,
Stéphanie Descroix +6 more
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Classical and Alternative Pathways of Mast Cell Activation
Critical Reviews™ in Immunology, 2002It has long since been recognized that mast cells are critical effectors of anaphylactic reactions, and the existence of these potentially hazardous cells has solely been justified due to their beneficial role in some infections with extracellular parasites. A novel understanding of mast cells as sentinels of the immune system has been made possible by
Lothar Hültner +2 more
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An immunofluorescence assay for complement activation by the classical pathway
Journal of Immunological Methods, 1981The functional integrity of classical complement pathway components was determined by an immunofluorescence (IFL) assay based on the capacity of cytoskeletal intermediate filaments (IMF) to bind C1q and to activate the complement pathway. The assay uses IMF-rich capillary endothelium of human term placentae as complement-activating substrate.
S. Meri, M. Rhen, Ewert Linder
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The Initiation Complexes of the Classical and Lectin Pathways
2006Various antigen structures initiate the classical and the lectin pathways of complement activation. Multidomain modular proteases (C1r, C1s and MASPs) are involved in the initiation complexes of both pathways. Despite the identical domain organization of these serine proteases there are differences in their specificities and functions.
Géza Ambrus +3 more
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Classical pathway deficiencies – A short analytical review
Molecular Immunology, 2015Deficiencies in the classical pathway of complement activation have some common features but show also great differences. Deficiencies of each of the components (C1q, C1s, C1r, C4 and C2) imply increased susceptibility to bacterial infections. They are also associated with increased risk to develop systemic lupus erythematosus where deficiency of C1q ...
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CLASSICAL COMPLEMENT PATHWAY IN HIV INFECTION
The Lancet, 1989E T Davies +5 more
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Synthesis of classical pathway complement components by chondrocytes.
Immunology, 1996Using immunohistochemical studies, C1q, C1s, C4 and C2 were detected in chondrocytes in normal human articular cartilage and macroscopically normal articular cartilage from the inferior surfaces of hip joints of patients with osteoarthritis. Using reverse-transcribed polymerase chain reaction (RT-PCR), mRNA for C1q, C1s, C4 and C2 was also detected in ...
Bradley, K. +6 more
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The adenosine pathway in immuno-oncology
Nature Reviews Clinical Oncology, 2020Bertrand Allard +2 more
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