Results 81 to 90 of about 4,411,154 (387)

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Algebraic Structure of Classical Field Theory: Kinematics and Linearized Dynamics for Real Scalar Fields

, 2019
We describe the elements of a novel structural approach to classical field theory, inspired by recent developments in perturbative algebraic quantum field theory.
Brunetti, Romeo, Fredenhagen, Klaus, Ribeiro, Pedro Lauridsen   +2 more
core   +1 more source

Pervasive mutations of JAK-STAT pathway genes in classical Hodgkin lymphoma.

Blood, 2018
Dissecting the pathogenesis of classical Hodgkin lymphoma (cHL), a common cancer in young adults, remains challenging because of the rarity of tumor cells in involved tissues (usually
E. Tiacci, Erik Ladewig, G. Schiavoni, A. Penson, Elisabetta Fortini, V. Pettirossi, Yuchun Wang, Ariele Rosseto, Alessandra Venanzi, Sofija Vlasevska, R. Pacini, S. Piattoni, A. Tabarrini, A. Pucciarini, B. Bigerna, A. Santi, A. Gianni, S. Viviani, A. Cabras, S. Ascani, B. Crescenzi, C. Mecucci, L. Pasqualucci, R. Rabadán, B. Falini   +24 more
semanticscholar   +1 more source

Classical and alternative complement pathway activation by pneumococci [PDF]

Infection and Immunity, 1977
Sixty-two strains of Streptococcus pneumoniae were studied for their abilities to consume selected components of classical and alternative complement pathways in human sera. The classical pathway was blocked by chelating calcium with ethyleneglycol-bios (beta-aminoethyl ether)-N,N-tetraacetic acid and by removing C4. The alternative pathway was blocked
W P Reed, C G Stephens, Ralph C. Williams   +2 more
openaire   +2 more sources

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

Cost‐effectiveness of multiparametric magnetic resonance imaging and MRI‐guided biopsy in a population‐based prostate cancer screening setting using a micro‐simulation model

Cancer Medicine, 2021
Background The introduction of multiparametric magnetic resonance imaging (mpMRI) and MRI‐guided biopsy has improved the diagnosis of prostate cancer. However, it remains uncertain whether it is cost‐effective, especially in a population‐based screening ...
Abraham M. Getaneh, Eveline AM Heijnsdijk, Harry J. deKoning   +2 more
doaj   +1 more source

Gain-of-Function Mutations R249C and S250C in Complement C2 Protein Increase C3 Deposition in the Presence of C-Reactive Protein

Frontiers in Immunology, 2021
The impairment of the alternative complement pathway contributes to rare kidney diseases such as atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G).
Aleksandra Urban, Daria Kowalska, Grzegorz Stasiłojć, Alicja Kuźniewska, Anna Skrobińska, Emilia Arjona, Eugenia Castellote Alonso, María Ángeles Fenollosa Segarra, Ilse Jongerius, Ilse Jongerius, Robbert Spaapen, Simon Satchell, Marcel Thiel, Stanisław Ołdziej, Santiago Rodriguez de Córdoba, Marcin Okrój   +15 more
doaj   +1 more source

The E5 oncoprotein of BPV-4 does not interfere with the biosynthetic pathway of non-classical MHC class I [PDF]

, 2006
The major histocompatibility complex (MHC) class I region in mammals contains both classical and non-classical MHC class I genes. Classical MHC class I molecules present antigenic peptides to cytotoxic T lymphocytes, whereas non-classical MHC class I ...
Anderson, Araibi, Ashrafi, Ashrafi, Ashrafi, B. Marchetti, Borrego, Cohen, Davies, Di Palma, E.H. Araibi, E.S. Dornan, Ellis, Ellis, Ellis, Frazer, G.H. Ashrafi, Geraghty, Hofmeister, M. Dobromylskyj, M.S. Campo, Marchetti, Marchetti, McQueen, O'Brien, Pennie, Piguet, Pizzato, Riteau, Roeth, S.A. Ellis, Storset, Storset, Tindle, Tomasec, Toye, Wang, Williams   +37 more
core   +1 more source

A Hierarchical Role for Classical Pathway Complement Proteins in the Clearance of Apoptotic Cells in Vivo

Journal of Experimental Medicine, 2000
The strongest susceptibility genes for the development of systemic lupus erythematosus (SLE) in humans are null mutants of classical pathway complement proteins. There is a hierarchy of disease susceptibility and severity according to the position of the
Philip R. Taylor, A. Carugati, V. Fadok, H. T. Cook, M. Andrews, Michael C. Carroll, J. Savill, Peter M. Henson, Marina Botto, Mark J. Walport   +9 more
semanticscholar   +1 more source

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source