Results 81 to 90 of about 681,433 (336)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
A Review of Pyroptosis in Liver Disease [PDF]
BIO Web of ConferencesPyroptosis is a new form of programmed cell death that is different from cell necrosis, apoptosis, and autophagy. It is characterized by the rupture of cell membranes mediated by Gasdermin and the release of cell contents and pro-inflammatory factors ...
Li Hao
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Editorial: Role of complement activation in kidney diseases
Frontiers in Medicine, 2023 Takashi Oda, Toshihiro Sawai
doaj +1 more source
Quantum Diffusive Dynamics of Macromolecular Transitions
, 2011 We study the role of quantum fluctuations of atomic nuclei in the real-time dynamics of non-equilibrium macro-molecular transitions. To this goal we introduce an extension of the Dominant Reaction Pathways (DRP) formalism, in which the quantum ...
Beccara, S. a +2 more
core +1 more source
Mechanisms of pre-mRNA splicing: classical versus non-classical pathways.
Histology and histopathology, 1998 Expression of genetic information proceeds through two major biological events, transcription and translation. However, in eukaryotic cells, the primary transcript (pre-mRNA) is not the template that the translational apparatus scans through, in order to produce the corresponding protein. Pre-mRNAs undergo several modifications (cap site addition, poly
openaire +3 more sources
Classical and novel GH receptor signaling pathways
Molecular and Cellular Endocrinology, 2020 In this review, I summarize historical and recent features of the classical pathways activated by growth hormone (GH) through the cell surface GH receptor (GHR). GHR is a cytokine receptor superfamily member that signals by activating the non-receptor tyrosine kinase, JAK2, and members of the Src family kinases.
openaire +3 more sources
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Use of C4d as a diagnostic tool to classify membranoproliferative glomerulonephritis
Nefrología, 2017 Background: Membranoproliferative glomerulonephritis (MPGN type I, II and III) was reclassified in 2013 as MPGN and C3 glomerulopathy (C3G) based on the complement system activation mechanism.
Nirupama Gupta +3 more
doaj +3 more sources
Научно-практическая ревматология, 2000 A relationship between X - ray joints changes and functional activity of classical pathway complement components in R4 was investigated. 31 patients with the moderate activity ofRA (ARA 1987) have been examined. Disease duration was 4,5lyear±3,84 (SD). X-
D. L. Goryachev, T. V. Lebedeva
doaj +1 more source