Results 191 to 200 of about 63,639 (257)

Macromolecule‐Loaded Hybrid Extracellular Vesicles via Ionic Lipid–Based Post‐Loading for Intracellular Delivery: Functional Evaluation for Neurodegenerative Therapy

Journal of Extracellular Biology, Volume 5, Issue 3, March 2026.
ABSTRACT Extracellular vesicles (EVs) are natural carriers that show promise as drug delivery systems (DDS). We developed a non‐invasive post‐loading method to encapsulate macromolecules in EVs using our proprietary ionic lipid base (ILB), which enables electrostatically driver hybridisation without disrupting EV structure.
Lin Cui, Fumiyasu Ono, Tomoko Ichinose, Masahiro Goto, Kohei Ishihama   +4 more
wiley   +1 more source

Insulin receptor trafficking and interactions in muscle cells. [PDF]

J Endocr Soc
Cen HH, Mattison AJ, Omidi A, Rogalski J, Abraham L, Gao G, Gold MR, Foster LJ, Gsponer J, Johnson JD.   +9 more
europepmc   +1 more source

Active Macropinocytosis, Lipid Catabolism, and Exhausting Immune Microenvironment of Ascites Tumor Cells Are Involved in Resistance to Platinum‐Based Therapy in Patients With High‐Grade Serous Ovarian Cancer

MedComm, Volume 7, Issue 3, March 2026.
Platinum‐resistant patients exhibited ascites suffer from immune exhaustion and enriched in lipids, which is used by tumor cells as energy resources to counteract platinum damage through active macropinocytosis and lipid catabolism. These resistant features in ascites can also predict, to a certain extent, the efficacy of platinum‐based therapy in ...
Ruiqi Zheng, Ying Cui, Xun Hu, Xin Dong, Bo Meng, Luhong Wen, Anqi Chen, Zijng Wang, Guifen Qiang, Shujun Cheng, Yang Zhao, Huiqin Guo, Ting Xiao   +12 more
wiley   +1 more source

Internalization-related host factors of common respiratory viruses. [PDF]

Front Immunol
Lv Q, Xie Z, Xu L.
europepmc   +1 more source

An Engineered Extracellular Vesicle With Enhanced Tumor and Lymph Nodes Targeting as siRNA Delivery System for Robust Tumor Immunotherapy

MedComm, Volume 7, Issue 3, March 2026.
Simple incubation with DP7‐C enables the generation of extracellular vesicles (DP‐EVs) with enhanced both tumor and lymph nodes targeting properties. DP‐EVs/siPD‐L1 can effectively inhibit tumor growth and greatly prolong the survival of tumor bearing mice through immune response activation and tumor microenvironment reprogramming.
Yusi Wang, Rui Zhang, Xuejing Zhou, Lin Tang, Die Hu, Yibing Zhang, Yuling Yang, Bailing Zhou, Li Yang   +8 more
wiley   +1 more source

Comparative Analysis of Methodological Aspects of the Study of Extracellular Vesicles and Extracellular Mitochondria: From Isolation to Internalization. [PDF]

Curr Issues Mol Biol
Yunusova N, Svarovsky D, Kaigorodova E, Dobrodeev A, Sisakian V, Tamkovich S.   +5 more
europepmc   +1 more source

Disruption of the l‐DOPA Receptor Gpr143/OA1‐Gene in Mice Creates a Unique Mixed Psychosis‐Like Phenotype

Neuropsychopharmacology Reports, Volume 46, Issue 1, March 2026.
We analyzed the behavior of GPR143 gene‐deficient mice. GPR143‐KO mice displayed a mixed psychiatric phenotype. GPR143 may play a role in mesolimbic and mesocortical functions underlying sensory gating, reward, social hierarchy, cognition, and emotional regulation. ABSTRACT GPR143, originally identified as the gene product of ocular albinism 1 (OA1), a
Yoshio Goshima, Haruko Nakamura, Motokazu Koga, Junka Koyama, Yayoi Kimura, Maya N. Vasishth, Evan Y. Snyder, Masashi Asai, Kenta Sakai, Daiki Masukawa   +9 more
wiley   +1 more source

Bioengineered Bacterial Vesicles and Biomimetic Hybrids Eliminate Biofilms and Balance the Gut Microbiome

Small, Volume 22, Issue 16, 17 March 2026.
Biomimetic nanocarriers based on liposomes and Myxobacteria outer‐membrane vesicles (OMVs) are effective antibiotic delivery systems. Hybrids have a higher drug loading and can target intracellular pathogens, while OMVs evade immune clearance. Biomimetic nanoantibiotics effectively eliminate the biofilms of Gram‐negative bacteria. Besides, Myxobacteria
Leila Pourtalebi Jahromi, Benedikt Kronast, Jennifer Munkert, Lorenzo Sana, Marcus Koch, Heike Danzer, Sirka Dormeyer, Shuhan Jiang, Fabian Herrmann, Matthias Weiler, Anna Kashkanova, Vahid Sandoghdar, Mario M. Zaiss, Gregor Fuhrmann   +13 more
wiley   +1 more source

Histamine H₁ Receptor-Mediated CREB Phosphorylation via G_q Protein Signaling and Arrestin Modulation. [PDF]

Pharmaceuticals (Basel)
Ogami R, Michinaga S, Iiboshi Y, Ogawa Y, Hishinuma S.   +4 more
europepmc   +1 more source