Results 81 to 90 of about 126,267 (387)
Advanced Biology, EarlyView.The invasive pest Halyomorpha halys causes significant crop losses requiring innovative pest control strategies such as RNA interference (RNAi). However, oral RNAi is largely ineffective in H. halys. This study shows that double‐stranded DNA (dsDNA) stabilizes dsRNA in saliva by inhibiting a highly expressed nuclease.
Venkata Partha Sarathi Amineni +2 more
wiley +1 more source
Phosphoinositide-mediated clathrin adaptor progression at the trans-Golgi network. [PDF]
, 2012 Clathrin-coated vesicles mediate endocytosis and transport between the trans-Golgi network (TGN) and endosomes in eukaryotic cells. Clathrin adaptors play central roles in coat assembly, interacting with clathrin, cargo and membranes.
Costaguta, Giancarlo +2 more
core +1 more source
Strain-dependent porcine circovirus type 2 (PCV2) entry and replication in T-lymphoblasts [PDF]
, 2019 Porcine circovirus type 2 (PCV2) is the etiological agent of PCV2-associated diseases (PCVAD). PCV2 targets lymphoblasts, and pigs suffering from PCVAD display lymphocyte depletion in lymphoid tissues. PCV2 infection of lymphoblasts has not been studied.
Nauwynck, Hans +2 more
core +1 more source
Revisiting the Role of Clathrin-Mediated Endoytosis in Synaptic Vesicle Recycling
Frontiers in Cellular Neuroscience, 2018 Without robust mechanisms to efficiently form new synaptic vesicles (SVs), the tens to hundreds of SVs typically present at the neuronal synapse would be rapidly used up, even at modest levels of neuronal activity.
Ira Milosevic
semanticscholar +1 more source
Advanced Functional Materials, EarlyView.The Angiopep‐2 peptide density on polymeric nanoparticles significantly impacts blood–brain barrier (BBB) penetration. This study explores this nuanced relationship using various in vitro models and in vivo assays, revealing that dynamic models better predict BBB penetration.
Weisen Zhang +9 more
wiley +1 more source
Clathrin Adaptor Complex-interacting Protein Irc6 Functions through the Conserved C-Terminal Domain. [PDF]
, 2019 Clathrin coats drive transport vesicle formation from the plasma membrane and in pathways between the trans-Golgi network (TGN) and endosomes. Clathrin adaptors play central roles orchestrating assembly of clathrin coats.
Costaguta, Giancarlo +2 more
core +2 more sources
Clathrin facilitates the morphogenesis of retrovirus particles.
PLoS Pathogens, 2011 The morphogenesis of retroviral particles is driven by Gag and GagPol proteins that provide the major structural component and enzymatic activities required for particle assembly and maturation.
Fengwen Zhang +4 more
doaj +1 more source
Versatile Cell Penetrating Peptide for Multimodal CRISPR Gene Editing in Primary Stem Cells
Advanced Functional Materials, EarlyView.CRISPR machinery in diverse molecular formats (DNA, RNA, and ribonucleic protein) is complexed into nanoparticles with the cell‐friendly arginine‐alanine‐leucine‐alanine (RALA) cell‐penetrating peptide. Nanoparticles are delivered to primary mesenchymal stem cells ex vivo or locally in vivo to facilitate multimodal CRISPR gene editing. This RALA‐CRISPR
Joshua P. Graham +9 more
wiley +1 more source
Influence of Fluctuating Membranes on Self-Assembly of Patchy Colloids
, 2012 A coarse-grained computational model is used to investigate the effect of a fluid membrane on patchy-particle assembly into biologically-relevant structures motivated by viral cores and clathrin.
Likos, Christos N., Matthews, Richard
core +1 more source
Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1. [PDF]
, 2014 BST2/tetherin, an antiviral restriction factor, inhibits the release of enveloped viruses from the cell surface. Human immunodeficiency virus-1 (HIV-1) antagonizes BST2 through viral protein u (Vpu), which downregulates BST2 from the cell surface.
Guatelli, John +7 more
core +1 more source