Results 11 to 20 of about 5,976,595 (218)

Transcriptomic analysis of Streptomyces clavuligerus ΔccaR::tsr: effects of the cephamycin C-clavulanic acid cluster regulator CcaR on global regulation

Microbial Biotechnology, 2014
Streptomyces clavuligerus ATCC 27064 and S. clavuligerus ΔccaR::tsr cultures were grown in asparagine‐starch medium, and samples were taken in the exponential and stationary growth phases.
R. Álvarez-Álvarez, A. Rodríguez-García, I. Santamarta, R. Pérez-Redondo, A. Prieto-Domínguez, Y. Martínez-Burgo, P. Liras   +6 more
semanticscholar   +1 more source

Antibiotic treatment using amoxicillin-clavulanic acid impairs gut mycobiota development through modification of the bacterial ecosystem

Microbiome, 2023
Background Effects of antibiotics on gut bacteria have been widely studied, but very little is known about the consequences of such treatments on the fungal microbiota (mycobiota).
M. Spatz, G. Da Costa, R. Ventin-Holmberg, J. Planchais, C. Michaudel, Yazhou Wang, C. Danne, Alexia Lapière, Marie‐Laure Michel, K. Kolho, P. Langella, H. Sokol, Mathias L. Richard   +12 more
semanticscholar   +1 more source

Efficacy and safety of switching from intravenous to oral antibiotics (amoxicillin-clavulanic acid) versus a full course of intravenous antibiotics in neonates with probable bacterial infection (RAIN): a multicentre, randomised, open-label, non-inferiority trial.

The Lancet Child & Adolescent Health, 2022
BACKGROUND Switching from intravenous antibiotic therapy to oral antibiotic therapy among neonates is not yet practised in high-income settings due to uncertainties about exposure and safety.
F. Keij, R. Kornelisse, N. Hartwig, Jacqueline van der Sluijs-Bens, Ron H T van Beek, Arianne van Driel, Linda G. M. van Rooij, Ilka van Dalen-Vink, Gertjan J. A. Driessen, S. Kenter, J. V. von Lindern, M. Eijkemans, Gerda M Stam-Stigter, Hongchao Qi, M. M. van den Berg, Martin G. A. Baartmans, L. H. van der Meer-Kappelle, C. B. Meijssen, O. Norbruis, J. Heidema, M. V. van Rossem, P. D. den Butter, K. Allegaert, I. Reiss, G. Tramper-Stranders   +24 more
semanticscholar   +1 more source

In vivo functional analysis of a class A β-lactamase-related protein essential for clavulanic acid biosynthesis in Streptomyces clavuligerus.

PLoS ONE, 2019
In Streptomyces clavuligerus, the gene cluster involved in the biosynthesis of the clinically used β-lactamase inhibitor clavulanic acid contains a gene (orf12 or cpe) encoding a protein with a C-terminal class A β-lactamase-like domain.
Santosh K Srivastava, Kelcey S King, Nader F AbuSara, Chelsea J Malayny, Brandon M Piercey, Jaime A Wilson, Kapil Tahlan   +6 more
doaj   +1 more source

Clavulanic Acid: A Novel Potential Agent in Prevention and Treatment of Scopolamine-Induced Alzheimer’s Disease

ACS Omega, 2022
Background and Aim: Alzheimer’s disease (AD) is the most common form of dementia in the elderly. It is characterized as a multifaced disorder with a greater genetic contribution.
Mahdieh Anoush, Zeinab Pourmansouri, Rafi Javadi, Benyamin GhorbanPour, A. Sharafi, Hamed Mohamadpour, I. Jafari Anarkooli, S. Andalib   +7 more
semanticscholar   +1 more source

Pharmacokinetics of Clavulanic Acid in the Pediatric Population: A Systematic Literature Review

Clinical Pharmacokinetics, 2022
Clavulanic acid is a commonly used β-lactam inhibitor in pediatrics for a variety of infections. Clear insight into its mode of action is lacking, however, and a target has not been identified.
F. Keij, G. Tramper-Stranders, B. Koch, Irwin K. M. Reiss, A. Muller, R. Kornelisse, K. Allegaert   +6 more
semanticscholar   +1 more source

Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways.

Food and Chemical Toxicology, 2021
Treatment of β-lactamase positive bacterial infections with a combination of amoxicillin (AMOX) and clavulanic acid (CLAV) causes idiosyncratic drug-induced liver injury (iDILI) in a relevant number of patients, often with features of intrahepatic ...
P. Petrov, P. Soluyanova, S. Sánchez‐Campos, J. Castell, R. Jover   +4 more
semanticscholar   +1 more source

Amoxicillin-Clavulanic Acid Resistance in the Genus Bifidobacterium

Applied and Environmental Microbiology, 2021
Based on our results, we observed a drastic reduction in gut microbiota diversity of children treated with antibiotics, which also affecting the abundance of Bifidobacterium, a bacterial genus commonly found in the infant gut.
L. Mancabelli, Walter Mancino, G. Lugli, Chiara Argentini, G. Longhi, C. Milani, Alice Viappiani, R. Anzalone, S. Bernasconi, D. van Sinderen, M. Ventura, F. Turroni   +11 more
semanticscholar   +1 more source

Supra and subgingival application of antiseptics or antibiotics during periodontal therapy

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases (gingivitis and periodontitis) are characterized by inflammatory processes which arise as a result of disruption of the balance in the oral ecosystem. According to the current S3 level clinical practice guidelines, therapy of patients with periodontitis involves a stepwise approach that includes the control of the patient ...
Elena Figuero, Jorge Serrano, Nicole Birgit Arweiler, Thorsten Mathias Auschill, Ali Gürkan, Gülnur Emingil   +5 more
wiley   +1 more source

Site-directed mutagenesis at the active site of Escherichia coli TEM-1 beta-lactamase. Suicide inhibitor-resistant mutants reveal the role of arginine 244 and methionine 69 in catalysis.

Journal of Biological Chemistry, 1992
Arginine 244 is a highly conserved residue in Class A beta-lactamases, while methionine 69 is not. Informational suppression experiments show that replacement of M69 by a leucine, or that of R244 by most other amino acids lead to clavulanic acid ...
M. Delaire, R. Labia, J. Samama, J. Masson   +3 more
semanticscholar   +1 more source