Results 21 to 30 of about 5,976,595 (218)

Proteome-wide alterations in an industrial clavulanic acid producing strain of Streptomyces clavuligerus

Synthetic and Systems Biotechnology, 2017
The usefulness of genetic/metabolic engineering for further improvement of industrial strains is subject of discussion because of the general lack of knowledge on genetic alterations introduced by iterative cycles of random mutagenesis in such strains ...
Eser Ünsaldı, Aslıhan Kurt-Kızıldoğan, Birgit Voigt, Dörte Becher, Gülay Özcengiz   +4 more
doaj   +1 more source

Dynamic kinetic resolution-mediated synthesis of C-3 hydroxylated arginine derivatives

Royal Society Open Science
Hydroxylated amino acids and their derivatives, including those found in proteins, are important in biology and medicinal chemistry. Incubation of N-acetyl-l-arginine with clavaminic acid synthase, a key oxygenase in clavulanic acid biosynthesis, affords
Ye Zheng, Zhenyu Chen, Guy J. Clarkson, Stephen A. Marshall, Jianliang Xiao, Christopher J. Schofield, Martin Wills, Andrew V. Stachulski   +7 more
doaj   +1 more source

Effect of amoxicillin‐clavulanic acid on clinical scores, intestinal microbiome, and amoxicillin‐resistant Escherichia coli in dogs with uncomplicated acute diarrhea

Journal of Veterinary Internal Medicine, 2020
Background Despite limited evidence of efficacy, antibiotic treatment is still frequently prescribed in dogs with uncomplicated acute diarrhea (AD). Objective To assess whether amoxicillin‐clavulanic acid has a clinical benefit, an effect on the fecal ...
Melanie Werner, J. Suchodolski, R. Straubinger, G. Wolf, J. Steiner, J. Lidbury, F. Neuerer, K. Hartmann, S. Unterer   +8 more
semanticscholar   +1 more source

Integrating One Health to Mitigate the Emergence and Spread of Antimicrobial Resistance in Livestock and Aquaculture

Animal Research and One Health, EarlyView.
Antimicrobial resistance (AMR) is an escalating global threat driven by antimicrobial use in aquaculture and livestock. Resistant pathogens and genes can spread across humans, animals, and the environment through interconnected ecosystems. Using a One Health approach, this review emphasizes antimicrobial stewardship, regulatory strengthening, enhanced ...
Mir Mohammad Ali, Delower Hossain, Ridwan Olamilekan Adesola, Anum Hanif, Shamsaldeen Ibrahim Saeed, Muhammad Abdul Mannan, Anoar Jamai Masroure, Kazi Estieque Alam, Md Kamal Hossain, Sabiha Zarin Tasnim Bristi, Md Jisan Ahmed   +10 more
wiley   +1 more source

Identification of antibiotic allergies in children using prescribing patterns in the electronic medical record

British Journal of Clinical Pharmacology, EarlyView.
Background By age three, 5%–75% of children have a documented antibiotic allergy (AL). Despite this prevalence, recognition remains low because of limited clinician knowledge and time. Our study evaluates a novel approach to identifying AL using electronic medical record (EMR) prescription patterns.
Georgia Koutsaplis, Kailey Tang, Renee Dimond, Alice Lei, Amanda Wilkins, Amanda Gwee   +5 more
wiley   +1 more source

Development of a β-lactamase-based aggregation-induced emission lateral flow strip for the detection of clavulanic acid in Milk

Food Chemistry: X
Lack of biorecognition elements significantly hinders the development of rapid detection methods for clavulanic acid (CA). To address this, we expressed Class A β-lactamases PC1 in vitro and demonstrated its high affinity for CA. Then we investigated the
Xiaonan Wang, Tong He, Leina Dou, Licai Ma, Xuezhi Yu, Zhanhui Wang, Kai Wen   +6 more
doaj   +1 more source

A descriptive case series of hepatotoxicity associated with CFTR modulators and possible relevance of pharmacogenetic polymorphisms in cystic fibrosis patients

British Journal of Clinical Pharmacology, EarlyView.
Cystic fibrosis transmembrane conductance regulator (CFTR) modulators are widely used in patients with cystic fibrosis and significantly improve respiratory function and quality of life. However, their effectiveness may be limited by liver damage, which sometimes leads to treatment discontinuation, and the mechanisms underlying this remain poorly ...
Clara Laffitte Redondo, Venceslas Bourdin, Abd El Kader Ait Tayeb, Sihem Benaboud, Inès Martins, Caroline Joyau, Myriam Benhamida, Isabelle Sermet‐Gaudelus, Clémence Martin, Pierre Régis Burgel, Céline Verstuyft, Laurent Chouchana, Estelle Ayme‐Dietrich   +12 more
wiley   +1 more source

Bone stability after regenerative peri‐implantitis treatment: A 10‐year follow‐up case study

Clinical Advances in Periodontics, EarlyView.
Abstract Background Peri‐implantitis poses a significant challenge to implant longevity, leading to progressive bone loss and potential implant failure. While reconstructive surgery has been proven effective in regenerating peri‐implant tissues, the long‐term stability of the regenerated tissues and the impact of supportive peri‐implant care (SPIC) on ...
Stefano Parma‐Benfenati, Marisa Roncati, Lucrezia Parma‐Benfenati, Paolo Nava   +3 more
wiley   +1 more source

Isolation and Identification of Pseudomonas aeruginosa from Soil Contaminated with Petroleum Products

Journal of Pure and Applied Microbiology
The amount of petroleum hydrocarbons affects biodegradation. Different classifications can be used to petroleum components Asphaltenes, ethers, fatty acids, porphyrins and resins saturated fatty acids.
Zahraa M. Al-Taee, Y.M. Liqaa, Rafal Ahmed Lilo, Aamal Muhsen Kadhum, Farah Mumtaz, Hadi Sajid Abdulabbas, Essam Murad Yousif, Autaf Talal Shaker, Mustafa Abdulrahman A. Al-kinani   +8 more
doaj   +1 more source

Subperiosteal peri‐implant augmented layer to correct bone dehiscence at immediate implant placement

Clinical Advances in Periodontics, EarlyView.
Abstract Background The purpose of the present case report is to describe the potential of the subperiosteal peri‐implant augmented layer (SPAL) technique in peri‐implant bone dehiscence (PIBD) correction at immediate implant placement (IIP). Methods This case report describes the application of the SPAL technique in two patients undergoing IIP at ...
Tommaso Grenzi, Chiara Franzini, Mattia Severi, Leonardo Trombelli   +3 more
wiley   +1 more source