Molecular genetics of naringenin biosynthesis, a typical plant secondary metabolite produced by Streptomyces clavuligerus [PDF]
, 2015 Background: Some types of flavonoid intermediates seemed to be restricted to plants. Naringenin is a typical plant metabolite, that has never been reported to be produced in prokariotes.
Albillos, Silvia M. +5 more
core +5 more sources
Synthetic and Systems Biotechnology, 2017 The usefulness of genetic/metabolic engineering for further improvement of industrial strains is subject of discussion because of the general lack of knowledge on genetic alterations introduced by iterative cycles of random mutagenesis in such strains ...
Eser Ünsaldı +4 more
doaj +1 more source
Cephalosporinases associated with outer membrane vesicles released by Bacteroides spp. protect gut pathogens and commensals against beta-lactam antibiotics [PDF]
, 2014 Objectives: To identify β-lactamase genes in gut commensal Bacteroides species and to assess the impact of these enzymes, when carried by outer membrane vesicles (OMVs), in protecting enteric pathogens and commensals.
Brearley, Charles +6 more
core +1 more source
Characterization of the Metabolic Response of Streptomyces clavuligerus to Shear Stress in Stirred Tanks and Single-Use 2D Rocking Motion Bioreactors for Clavulanic Acid Production [PDF]
, 2019 Streptomyces clavuligerus is a gram-positive filamentous bacterium notable for producing clavulanic acid (CA), an inhibitor of β-lactamase enzymes, which confers resistance to bacteria against several antibiotics.
Gómez-Ríos, David +5 more
core +1 more source
Multiple acquired portosystemic shunts in a cat secondary to chronic diaphragmatic rupture [PDF]
, 2015 A cat with a chronic diaphragmatic rupture presented with neurological signs, including twitching and focal seizures. Blood ammonia level was markedly elevated and therefore neurological signs were thought to be related to hepatic encephalopathy ...
Birchard SJ +3 more
core +3 more sources
Transcriptome and translatome profiles of Streptomyces species in different growth phases. [PDF]
, 2020 Streptomyces are efficient producers of various bioactive compounds, which are mostly synthesized by their secondary metabolite biosynthetic gene clusters (smBGCs).
Cho, Byung-Kwan +6 more
core +1 more source
Dynamic kinetic resolution-mediated synthesis of C-3 hydroxylated arginine derivatives
Royal Society Open ScienceHydroxylated amino acids and their derivatives, including those found in proteins, are important in biology and medicinal chemistry. Incubation of N-acetyl-l-arginine with clavaminic acid synthase, a key oxygenase in clavulanic acid biosynthesis, affords
Ye Zheng +7 more
doaj +1 more source
Evolution of Drug Resistance: Insight on TEM β-Lactamases Structure and Activity and β-Lactam Antibiotics [PDF]
, 2014 Since the discovery of the first penicillin bacterial resistance to β-lactam antibiotics has spread and evolved promoting new resistances to pathogens.
Fernandes, Rúben +2 more
core +1 more source
Molecular Investigations of PenA-mediated β-lactam Resistance in Burkholderia pseudomallei [PDF]
, 2011 Burkholderia pseudomallei is the etiological agent of melioidosis. Because of the bacterium’s intrinsic resistance and propensity to establish latent infections, melioidosis therapy is complicated and prolonged. Newer generation b-lactams, specifically
Drew A Rholl +6 more
core +1 more source
A stable liquid–liquid extraction system for clavulanic acid using polymer-based aqueous two-phase systems [PDF]
, 2012 The partitioning of Clavulanic Acid (CA) in a novel inexpensive and stable aqueous two-phase system (ATPS) composed by poly(ethylene glycol) (PEG) and sodium polyacrylate (NaPA) has been studied.
Johansson, Hans-Olof, +5 more
core +1 more source