Clear Cell Renal Cell Carcinoma: From Biology to Treatment
Cancers, 2023 Simple Summary Over the past two decades, biological discoveries have transformed the treatment strategies for renal cell carcinoma. These advances have led to the development of agents targeting pro-angiogenic pathways and the immunogenicity of renal ...
Adam M. Kase +2 more
semanticscholar +1 more source
Identifying mRNA targets of microRNA dysregulated in cancer: with application to clear cell Renal Cell Carcinoma [PDF]
, 2010 BACKGROUND. MicroRNA regulate mRNA levels in a tissue specific way, either by inducing degradation of the transcript or by inhibiting translation or transcription.
Huiqing Liu +13 more
openalex +7 more sources
Snail heterogeneity in clear cell renal cell carcinoma [PDF]
BMC Cancer, 2016 Intratumor heterogeneity may be responsible of the unpredictable aggressive clinical behavior that some clear cell renal cell carcinomas display. This clinical uncertainty may be caused by insufficient sampling, leaving out of histological analysis foci of high grade tumor areas.
José I. López +6 more
openaire +4 more sources
The Tumor Immune Microenvironment in Clear Cell Renal Cell Carcinoma
International Journal of Molecular Sciences, 2023 Clear cell renal cell carcinoma (ccRCC) is a type of kidney cancer that arises from the cells lining the tubes of the kidney. The tumor immune microenvironment (TIME) of ccRCC is a complex interplay of various immune cells, cytokines, and signaling ...
Cesar U. Monjaras-Avila +5 more
semanticscholar +1 more source
Treatment strategies for clear cell renal cell carcinoma: Past, present and future
Frontiers in Oncology, 2023 Clear cell renal cell carcinoma (ccRCC) is the most prevalent histological subtype of kidney cancer, which is prone to metastasis, recurrence, and resistance to radiotherapy and chemotherapy.
Junwei Yang, Kuansong Wang, Zhichun Yang
semanticscholar +1 more source
Gene expression profiling of clear cell papillary renal cell carcinoma: comparison with clear cell renal cell carcinoma and papillary renal cell carcinoma [PDF]
Modern Pathology, 2014 Clear cell papillary renal cell carcinoma is a distinct variant of renal cell carcinoma that shares some overlapping histological and immunohistochemical features of clear cell renal cell carcinoma and papillary renal cell carcinoma. Although the clear cell papillary renal cell carcinoma immunohistochemical profile is well described, clear cell ...
Andrew N. Young +9 more
openaire +2 more sources
Renal Lipid Metabolism Abnormalities in Obesity and Clear Cell Renal Cell Carcinoma
Metabolites, 2021 Clear cell renal cell carcinoma is the most common and deadly type of cancer affecting the kidney, and is characterized histologically by large intracellular lipid deposits.
Ion Alexandru Bobulescu +8 more
doaj +1 more source
Journal of Clinical Oncology, 2021 PURPOSE Programmed death 1 (PD-1) pathway inhibitors have not been prospectively evaluated in patients with non–clear cell renal cell carcinoma (nccRCC).
D. McDermott +18 more
semanticscholar +1 more source
Radiogenomics in clear cell renal cell carcinoma: correlations between advanced CT imaging (texture analysis) and microRNAs expression [PDF]
, 2019 Purpose: A relevant challenge for the improvement of clear cell renal cell carcinoma management could derive from the identification of novel molecular biomarkers that could greatly improve the diagnosis, prognosis, and treatment choice of these ...
Badia, S. +12 more
core +1 more source
Genes, 2022 Clear cell renal cell carcinoma (ccRCC) is the most prevalent subtype of renal cell carcinoma, which is characterized by metabolic reprogramming. Cuproptosis, a novel form of cell death, is highly linked to mitochondrial metabolism and mediated by ...
Zilong Bian, Rong Fan, Lingmin Xie
semanticscholar +1 more source