Results 61 to 70 of about 1,796 (161)

MECP2 Insufficiency Attenuates RUNX2‐Dependent Osteoblast Differentiation via miR‐126‐3p/DKK1‐Mediated Canonical Wnt Signaling Inhibition in Rett Syndrome

The FASEB Journal, Volume 40, Issue 4, 28 February 2026.
MECP2 insufficiency leads to upregulation of miR‐126‐3p, which in turn enhances the endogenous Wnt antagonist DKK1. DKK1 inhibits the canonical Wnt signaling pathway, thereby impairing RUNX2‐dependent osteoblast differentiation. ABSTRACT Rett syndrome (RTT) is a rare neurodevelopmental disorder caused by loss‐of‐function mutations in the gene encoding ...
Shuangshan Dong, Lu Wang, Hiroki Kato, Saki Hirofuji, Zhiyan Zhou, Yosuke Ito, Yuta Hirofuji, Hiroshi Sato, Takahiro A. Kato, Yasunari Sakai, Shouichi Ohga, Satoshi Fukumoto, Keiji Masuda   +12 more
wiley   +1 more source

The Metacarpophalangeal Pattern Profile: An Old Method With New Insights Into the Evaluation of Short Stature

American Journal of Human Biology, Volume 38, Issue 2, February 2026.
ABSTRACT Objective To characterize the metacarpophalangeal pattern profile (MCPP) of healthy children and adolescents from São Paulo, Brazil, and to establish percentile curves by chronological age (CA), bone age (BA), and sex using the LMS method. Additionally, to compare these findings with previous population‐based data and to apply the derived ...
Marcelo Damaso Maruichi, Bruno Telma Destailleur, Giulia Maesta Apelbaum, Carlos Alberto Longui, Cristiane Kochi   +4 more
wiley   +1 more source

A Rare Case Report of Four Bilateral Maxillary Lateral Incisors in a Non‐Syndromic Patient

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Bilateral supernumerary maxillary lateral incisors in non‐syndromic adults are extremely rare and pose diagnostic and treatment challenges. This case report describes a 34‐year‐old male with esthetic concerns and malocclusion, successfully managed through strategic extraction, transverse expansion, and fixed orthodontic therapy, achieving ...
Seyed‐Mohsen Hosseini‐Adib, Mona Kazemi   +1 more
wiley   +1 more source

A rare presentation of cleidocranial dysplasia [PDF]

BMJ Case Reports, 2012
Cleidocranial dysplasia (CCD) is a rare skeletal dysplasia characterised by a defect in ossification. Frequently reported clinical findings are delayed closure of the fontanelles and cranial sutures, hypoplastic clavicles, dental abnormalities and short stature. Our patient suffered from complete absence of ossification of both parietal bones.
Ilse, Broeks, Irma E, Veenstra-Knol, Arvid W A, Kamps   +2 more
openaire   +2 more sources

Pediatric Dental Management of a Patient With Infantile Osteopetrosis in Remission: A Clinical Case Report

Case Reports in Dentistry, Volume 2026, Issue 1, 2026.
Background Osteopetrosis is a rare genetic disorder characterized by increased bone density due to defective osteoclast function. Its clinical presentation varies according to subtype, and oral manifestations are frequent, potentially serving as early indicators of the disease.
Maria Amalia Cruz-Morera, Katherine Molina-Chaves, Adrian Gomez-Fernandez, Hannah Wesley   +3 more
wiley   +1 more source

High Expression of IGSF10 Confers an Inhibitory Effect on the Progression of Lung Adenocarcinoma

Journal of Cellular and Molecular Medicine, Volume 29, Issue 24, December 2025.
ABSTRACT Lung cancer is one of the most frequently diagnosed cancers and the leading cause of cancer‐related deaths worldwide. Unlike conventional treatments, the targeted therapies or emerging immunotherapies have shown significant advantages in the management of advanced lung cancer.
Lianyu Cheng, Beibei Ma, Yun Zhao, Chunyan Qin, Lihe Jiang, Bo Ling   +5 more
wiley   +1 more source

The PI3K/AKT/mTOR Pathway and Oral Diseases: A Bibliometric Analysis From 2008 to 2025

Clinical and Experimental Dental Research, Volume 11, Issue 5, October 2025.
ABSTRACT Objectives The phosphoinositide 3 kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway is a key therapeutic target for oral diseases. This study uses bibliometric analysis to identify research trends, knowledge gaps, and the development of PI3K/AKT/mTOR‐targeted therapies.
Yena Gan, Duoduo Li, He Xu, Sheng Han, He Zhu, Zening Wei, Zhigang Cai, Jinwei Huang   +7 more
wiley   +1 more source

Clinical and genetic study on a cleidocranial dysplasia family [PDF]

Kouqiang yixue
Objective To confirm the mutation in a family with cleidocranial dysplasia (CCD) and explore its possible effects on protein structure and function.
ZHANG Xinyu, MAO Ji, CHENG Tingting, MA Lan, CHENG Liming, PAN Yongchu
doaj   +1 more source

Combined surgical-orthodontic treatment of patients with cleidocranial dysplasia: case report and review of the literature

Orphanet Journal of Rare Diseases, 2018
Objectives To study the present treatment situation and investigate a better orthodontic approach for patients with cleidocranial dysplasia (CCD) through systematically reviewing the published cases and to conclude the surgical-orthodontic treatment ...
Yanfei Zhu, Yin Zou, Qian Yu, Huijun Sun, Sixuan Mou, Shuhua Xu, Min Zhu   +6 more
doaj   +1 more source

Advantages of cone beam computed tomography (CBCT) in the orthodontic treatment planning of cleidocranial dysplasia patients: a case report

Head & Face Medicine, 2011
Our aim was to discuss, by presenting a case, the possibilities connected to the use of a CBCT exam in the dental evaluation of patients with Cleidocranial Dysplasia (CCD), an autosomal dominant skeletal dysplasia with delayed exfoliation of deciduous ...
Zotti Francesca, Tonni Ingrid, Laffranchi Laura, Dalessandri Domenico, Piancino Maria, Paganelli Corrado, Bracco Pietro   +6 more
doaj   +1 more source