Results 91 to 100 of about 209,174 (306)

Development of a Novel Synthetic Hydrogel Sealant for Effective Prevention of Liver Resection‐Associated Bile Leakage

Advanced Healthcare Materials, EarlyView.
A dual‐crosslinking poly(ethylene glycol) (PEG) hydrogel is presented that rapidly solidifies and progressively adheres to tissue, achieving durable sealing of bile leaks. In hepatectomy models, this system prevents postoperative complications more effectively than conventional sealants, highlighting its translational potential as a safe and efficient ...
Kazuyoshi Matsubara, Shohei Ishikawa, Hiroyuki Kamata, Almog Gur, Ayano Fujisawa, Shu Nishida, Katsuyuki Hoshina, Takamasa Sakai   +7 more
wiley   +1 more source

Application of Droplet-Array Sandwiching Technology to Click Reactions for High-Throughput Screening

Micromachines
High-throughput screening (HTS) is an essential process in drug discovery, requiring platforms that ensure reagent economy, high efficiency, and resistance to cross-contamination.
Yoshinori Miyata, Shoma Nishimura, Sora Kawakami, Yuriko Higuchi, Satoshi Konishi   +4 more
doaj   +1 more source

Click Chemistry

Drug Delivery System, 2023
Suguru Yoshida, Tomoki Nishimura
openaire   +1 more source

DOTA chelation through click chemistry enables favorable biodistribution of ⁸⁹ Zr-radiolabeled antibodies: A comparison with DFO chelation [PDF]

, 2022
Ryota Imura, Yoshitaka Kumakura, Lin Yan, Yuki Shimoura, Hiroyuki Takahashi, Hiroyuki Ida, Youichiro Wada, Nobuyoshi Akimitsu   +7 more
openalex   +1 more source

Spatial Patterning of Modular Gelatin‐Peroxide Microspheres in Melt‐Electrowritten Scaffolds Provides Controlled Oxygen Generation and Mitigates Hypoxia and Cytotoxicity

Advanced Healthcare Materials, EarlyView.
A bioassembly approach is described using photo‐crosslinked gelatin‐based microgels containing calcium peroxide (CaO2) to generate oxygen (O2) and enhance cell survival in hypoxic conditions (1% O2). Bioassembly enables spatial patterning of individual CaO2‐laden and mesenchymal stem cell (MSC)‐laden microgels and allows for decoupling and mitigating ...
Axel E. Norberg, F. Max Yavitt, Ezgi Bakirci, Khoon Lim, Tim B. F. Woodfield, Gabriella C. J. Lindberg   +5 more
wiley   +1 more source

Bioorthogonal Click Chemistry: Covalent Labeling in Living Systems [PDF]

, 2007
Jeremy M. Baskin, Carolyn R. Bertozzi
openalex   +1 more source

Click Chemistry in Proteomic Investigations [PDF]

, 2020
Christopher G. Parker, Matthew R. Pratt
openalex   +1 more source

Evaluation of Azido 3-Deoxy-d-manno-oct-2-ulosonic Acid (Kdo) Analogues for Click Chemistry-Mediated Metabolic Labeling of Myxococcus xanthus DZ2 Lipopolysaccharide [PDF]

, 2022
Fares Saïdi, Oscar Javier Gamboa Marin, José Ignacio Veytia‐Bucheli, Evgeny Vinogradov, Gokulakrishnan Ravicoularamin, Nicolas Y. Jolivet, Ahmad A. Kezzo, Eric Ramirez Esquivel, Adyasha Panda, Gaurav Sharma, Stéphane P. Vincent, Charles Gauthier, Salim T. Islam   +12 more
openalex   +1 more source

IL‐2 Free Expansion of T Cells with Immunofilaments

Advanced Healthcare Materials, EarlyView.
Ratio and density of stimulatory αCD3 and αCD28 mAb on immunofilaments (IF) influence T cell expansion, cytokine production, and effector phenotype. Moreover, IL‐2 supplementation is not necessary with optimal performing IFs, which leads to simpler culture conditions, and negative side effects of IL‐2 supplementation are reduced.
Marjolein Schluck, Lea Weiss, René Classens, Carl G. Figdor, Roel Hammink   +4 more
wiley   +1 more source

Prospects of click chemistry reactions in nuclear medicine: the TCO-Tz reaction based on the IEDDA mechanism

Nuclear Medicine Review
Click chemistry reactions, characterized by their high efficiency, strong selectivity, unique in vivo pre-targeting capabilities, and bioorthogonality, have shown great promise in nuclear medicine in recent years.
Yufeng Jing, Jiameng Liu, Chaoming Mao, Yufei Mao   +3 more
doaj   +1 more source