Results 111 to 120 of about 1,290,910 (349)
Advanced Healthcare Materials, EarlyView.Protease‐degradable hydrogels mimic dynamic cell‐matrix interactions, but controlling hydrogel degradation is a challenge. We screen libraries of peptides to identify sequences that are primarily degraded by membrane‐localized proteases. Crosslinking hydrogels with these peptides enables cell to spread and migrate while reducing matrix degradation ...
Yingjie Wu +3 more
wiley +1 more source
Click chemistry in the development of PROTACs
RSC Chemical BiologyThis review discusses leveraging click chemistry to address unmet needs in PROTAC development.
Ce Yang, Ravi Tripathi, Binghe Wang
openaire +2 more sources
Norbornene Homopolymerization Limits Cell Spreading in Thiol–Ene Photoclick Hydrogels
Advanced Healthcare Materials, EarlyView.Thiol–norbornene click reactions are often used in the development of cell‐permissive 3D hydrogels. However, ene–ene crosslinks in other thiol–ene systems are known to limit permissivity. This study demonstrates the negative effects of norbornene homopolymerization on 3D cell spreading and circumvents the issue by modulating polymer degree of ...
James L. Gentry, Steven R. Caliari
wiley +1 more source
Granular Hydrogels as Modular Biomaterials: From Structural Design to Biological Responses
Advanced Healthcare Materials, EarlyView.Granular hydrogels are now emerging as promising biomaterials due to their inherent microporousity, injectability, and modularity. They have shown improvements in cell viability and migration, cellular/tissue infiltration, host tissue integration, mitigated foreign body response, and tissue regeneration.
Asmasadat Vaziri +6 more
wiley +1 more source
The 2022 Nobel Prize in Chemistry for the development of click chemistry and bioorthogonal chemistry
Analytical and Bioanalytical Chemistry, 2023 J. Zaia
semanticscholar +1 more source
New Azo Chromophore‐Containing Conjugated Polymers: Facile Synthesis by Using “Click” Chemistry and Enhanced Nonlinear Optical Properties Through the Introduction of Suitable Isolation Groups [PDF]
, 2007 Zhong’an Li +6 more
openalex +1 more source
Synthetic utility and reactivity of N-alkynylazoles [PDF]
, 2015 textThe chemistry of N-alkynylazoles is a newly emerging area of chemistry with particular interest in heterocycle synthesis. Synthetic preparations of this class of molecule have shown an increasing presence in literature, however, the synthetic ...
Gilbreath, Bradford Lynd
core
Advanced Healthcare Materials, EarlyView.A synthetic 4‐arm maleimide‐terminated poly(ethylene glycol) (PEG‐4MAL) hydrogel system that combines hydrolytic ester‐linked macromer (PEG‐4eMAL) with nondegradable amide‐linked macromer (PEG‐4aMAL) in various stoichiometric ratios to tune the degradability rate. The macromers are crosslinked with dithiothreitol via thiol‐maleimide click reaction. The
Michael D. Hunckler +7 more
wiley +1 more source
Click chemistry surface functionalization for resonant micro-cavity sensors [PDF]
, 2015 Micro-cavity resonant sensors have outer surfaces that are functionalized using click chemistry, e.g., involving a cycloaddition reaction of an alkyne functional group and an azide functional group.
Alabi, Akinleye C. +4 more
core +1 more source
Transforming Cancer Diagnosis and Therapy Through Fluorescent Hydrogels: A Review
Advanced Healthcare Materials, EarlyView.This article reviews fluorescent hydrogel systems for cancer detection, monitoring, and therapy. Mimicking the tumor microenvironment, these hydrogels enable real‐time imaging and targeted drug delivery. The review discusses design strategies, labeling techniques, and applications, highlighting challenges and future opportunities in cancer diagnostics ...
Elahe Masaeli +2 more
wiley +1 more source