Results 181 to 190 of about 328,516 (352)
New Methodology to Search for DNA Binding Ligands Based on Duplex DNA-Templated Click Chemistry [PDF]
, 2008 Shion Imoto +2 more
openalex +1 more source
Advanced Science, EarlyView.Schematic diagram showing the potential mechanism of bigelovin on the activation of NLRP3 inflammasome Bigelovin may inhibit activated protein C kinase 1 (RACK1) by directly binding with cys168 of RACK1. Bigelovin thus prevents oligomerization of NLRP3 (NLRP3 active conformation) and subsequent assembly of NLRP3 inflammasome, blocking the activation of
Jian Cui +17 more
wiley +1 more source
Iterative In Situ Click Chemistry Creates Antibody‐like Protein‐Capture Agents [PDF]
, 2009 Heather D. Agnew +12 more
openalex +1 more source
Advanced Science, EarlyView.Meisoindigo targets PKMYT1 for degradation by acting as a molecular glue that enhances PKMYT1‐TRIM25 interaction, leading to K48‐linked ubiquitination and subsequent proteasomal degradation, thereby exerting therapeutic effects in chronic myeloid leukemia.
Zhao‐Xin Zhang +10 more
wiley +1 more source
The development of thiophosphoryl 'click' chemistry [PDF]
, 2009 We have established novel, aqueous 'Click' chemistry that is based on the thiophosphoryl group. Two systems for the creation of thiophosphoryl derivatives were involved: Thiophosphoramidate I and Bromoacetyl II.
Trmcic, Milena
core
Target Identification by Diazirine Photo‐Cross‐Linking and Click Chemistry [PDF]
, 2009 Andrew L. MacKinnon, Jack Taunton
openalex +1 more source
Advanced Science, EarlyView.The Fe3O4/Gd@BSA‐pPB nanoprobe leverages biomimetic mineralization and targets hepatic stellate cells (HSCs) through PDGFRβ, offering superior enrichment in fibrotic regions. This targeted delivery overcomes biological barriers, enhancing both the accuracy and sensitivity of MRI imaging at early disease stages.
Zehua Li +11 more
wiley +1 more source
Metal-Free “Click” Chemistry: Efficient Polymer Modification via 1,3-Dipolar Cycloaddition of Nitrile Oxides and Alkynes [PDF]
, 2009 Ishwar Singh +3 more
openalex +1 more source
Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration
Advanced Science, EarlyView.The article explores a novel therapeutic strategy for cardiac regeneration by targeting miRNA‐1a and miRNA‐15b. Combinatorial inhibition of miR‐1a and miR‐15b enhances cardiomyocyte proliferation, improves heart function, and reduces fibrosis in myocardial infarction models.
Ting Yuan +16 more
wiley +1 more source
EJNMMI Radiopharmacy and ChemistryBackground Currently, the synthesis pathway of metal nuclide-labeled radiopharmaceuticals is mainly divided into two steps: first, connecting the chelator with the target molecule, and second, labeling the metal nuclide to the chelator.
Xiaobei Zheng +13 more
doaj +1 more source