Results 181 to 190 of about 209,174 (306)

Droplet Digital CRISPR for Nucleic Acid Detection

Advanced Science, EarlyView.
This review outlines recent advances in droplet digital CRISPR technology for nucleic acid detection, combining CRISPR specificity with droplet digital‐based absolute quantification. It summarizes core principles, amplification‐assisted and amplification‐free strategies, and representative DNA and RNA biomarker applications.
Yang Zhang, Roy S. K. Walker, Anwar Sunna, Tracie J. Barber, Ming Li   +4 more
wiley   +1 more source

Model-Assisted Process Optimization for Trivalent Ligand-siRNA Conjugation via CuAAC Click Chemistry. [PDF]

ACS Omega
Pan F, Yang S, Zhang R, Li J, Liu G, Chen J.   +5 more
europepmc   +1 more source

Review for "Simple click chemistry‐based derivatization to quantify endogenous formaldehyde in milk using ultra‐high‐performance liquid chromatography tandem mass spectrometry in selected reaction monitoring mode"

, 2020
Ana Barros
openalex   +1 more source

A Tangentially Sensitive Tactile Sensor Reveals the Stick‐Slip Mechanism and Enhances Robotic Tactile Sensing

Advanced Science, EarlyView.
An ultralight, multilayer anisotropic tactile sensor—an artificial Pacinian corpuscle—exhibits ultrahigh tangential sensitivity (1022 kPa−1) and spatiotemporal sensing. It discriminates static, sliding, and rolling contacts, detects incipient stick–slip via high‑frequency signatures, and enhances robotic touch (100%/98.18% accuracy for active/passive ...
Jinghui Wang, Xiaoyu Liu, Yujiao Du, Yepu Chen, Jieyi Guo, Linyuan Fan, Min Tang, Xiaofeng Qiao, Yuanjie Zhu, Zhiyang Zhang, Chaojie Dong, Lizhen Wang, Yubo Fan   +12 more
wiley   +1 more source

Microfluidic Assembly of Poly(glutamic acid) Nanogels Through SPAAC Click Chemistry. [PDF]

Pharmaceutics
Mastella P, Luin S.
europepmc   +1 more source

Mechanisms of Aristolochic Acid Resistance in Specialist Butterflies and Evolutionary Insights for Potential Protective Pathways

Advanced Science, EarlyView.
The study provides an extreme example of insect adaptation to highly toxic defenses of host plants, and investigates the complex strategies to resist carcinogenic aristolochic acids, including physical isolation, metabolic detoxification, and DNA repair.
Yang Luan, Yubo Zhang, Jingjing Li, Jianqing Zhu, Yuyang Lei, Yushi Hu, Zhenqiang Xin, Tianpei Xie, Jiang Zheng, Yuanyuan Lin, Jingjing Shen, Yiyi Cao, Xinyue You, Jing Xi, Jiaying Wu, Weiying Liu, Xinyu Zhang, Yuanting Zheng, David J. Lohman, Leming Shi, Wei Zhang   +20 more
wiley   +1 more source

Engineering Alloxazines by Boron Coordination and Click Chemistry toward Small-molecule Fluorescent Probes. [PDF]

Chemistry
Charpentier O, Mouhanna A, Nikolopoulos E, Guenet A, Gourlaouen C, Desage-El Murr M.   +5 more
europepmc   +1 more source

Complementary Base Lowers the Barrier in SuFEx Click Chemistry for Primary Amine Nucleophiles

, 2020
Jan‐Niclas Luy, Ralf Tonner
openalex   +2 more sources

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Modular Virus-like Particles for Antigen Presentation: Comparing Genetic Fusion and Click-Chemistry for Purification. [PDF]

Int J Mol Sci
Balbierer K, Jenzelewski V, Herrmann FC, Piontek M, Jose J.   +4 more
europepmc   +1 more source