Results 271 to 280 of about 1,290,910 (349)

MUC15 Ectodomain Architecture Regulates Integrin Clustering to Control Cancer Metastasis

Advanced Science, EarlyView.
This study uncovers a size‐dependent adhesion paradigm, demonstrating that the glycocalyx protein MUC15 suppresses pancreatic cancer progression by attenuating integrin activation, focal adhesion assembly, and YAP mechanotransduction. Integrating computational modeling and experimental validation, the work reveals a mechanical mechanism by which MUC15 ...
Simei Zhang, Hongyuan Zhu, Zeen Zhu, Shuai Wu, Yiqun Song, Jin Wang, Xinlong Chen, Weikun Qian, Jianpeng Li, Yangyang Yue, Qinhong Xu, Zhiping Ruan, Qing Li, Yaomin Zhu, Tian Jian Lu, Guy M. Genin, Feng Xu, Zheng Wang, Min Lin   +18 more
wiley   +1 more source

Lanthanide-tetrazine probes for bio-imaging and click chemistry. [PDF]

Chem Sci
Woolley B, Wu Y, Xiong L, Chau HF, Zhang J, Law GL, Wong KL, Long NJ.   +7 more
europepmc   +1 more source

ZDHHC2‐Dependent Palmitoylation Dictates Ferroptosis and Castration Sensitivity in Prostate Cancer via Controlling ACSL4 Degradation and Lipid Peroxidation

Advanced Science, EarlyView.
Our study reveals a novel mechanism by which palmitoylation regulates ferroptosis and enzalutamide resistance in prostate cancer. Under enzalutamide resistance, the FOXA1/CXXC5/TET2 complex induces aberrant upregulation of ZDHHC2, which subsequently suppresses ferroptosis by mediating S‐palmitoylation of USP19 and degradation of ACSL4 protein in CRPC ...
Shuai Shao, Wei Li, Yulong Hong, Ruijiang Zeng, Liang Zhu, Lu Yi, Yuan Li, Yinhuai Wang, Haojie Huang, Xuewen Jiang, Xin Jin   +10 more
wiley   +1 more source

Noninvasive Assessment of β-Secretase Activity Through Click Chemistry-Mediated Enrichment of Neuronal Extracellular Vesicles to Detect Alzheimer's Disease. [PDF]

Adv Sci (Weinh)
Kim H, Lee J, Qian A, Ji YR, Zhang R, Hu Q, Williams CK, Chuang HY, Smalley MD, Xu Y, Gao L, Mayo MC, Zhang T, Posadas EM, Tan ZS, Vinters HV, Vossel K, Magaki S, Zhu Y, Tseng HR.   +19 more
europepmc   +1 more source

A Metalloporphyrin Nanosystem Enables Non‐Invasive Visualization and Specific Treatment for Thrombosis and Ischemic Stroke

Advanced Science, EarlyView.
Thrombotic ischemic stroke is a severe neurological disease of the brain that presents major challenges for effective diagnosis and treatment. Precisely engineered Ir and Mn cores within a single porphyrin framework of 4IrMn nanoparticles enable endogenous ONOO−‐ or laser‐activated switching among NIR‐CL imaging, photothermal / photodynamic therapy ...
Ziwei Wang, Liping Zhang, Zihan Wu, Nan Xiao, Wenxin Zheng, Yachao Wang, Gelin Xu, Dongxia Zhu, Martin R. Bryce, Lijie Ren, Ben Zhong Tang   +10 more
wiley   +1 more source

Versatile Click Chemistry-based Approaches to Illuminate DNA and RNA G-Quadruplexes in Human Cells. [PDF]

Bio Protoc
Pipier A, Monchaud D.
europepmc   +1 more source

Green Approach in Click Chemistry

, 2018
Sachin P. Shirame, Raghunath B. Bhosale
openaire   +3 more sources

Superwettable‐Membrane‐Assisted Extraction and Separation as a General Method for Removal of Organic Pollutants From Water

Advanced Science, EarlyView.
An integrated liquid‐liquid extraction and in situ superwettable membrane separation system is developed for efficient removal of organic pollutants from wastewater. After being treated with this novel technology, the residual organic pollutants are < 1.5 ppm with a removal efficiency > 95.5% and a TOC < 40 ppm, demonstrating a scalable and sustainable
Deqi Wang, Ting Zhang, Fan Min, Yifeng Gao, Jiaming Zhu, Ganhua Xie, Zonglin Chu   +6 more
wiley   +1 more source

Micro/Nanorobots for Combating Brain Disorders: Challenges, Advances, and Perspectives

Advanced Science, EarlyView.
Micro/nanorobots (MNRs) offer a transformative approach for precision therapy in brain disorders. By overcoming biological barriers and enabling controlled propulsion, targeted delivery, and real‐time imaging/tracking, MNRs pave the way toward effective, minimally invasive treatments. This review outlines the interplay between brain disease challenges,
Qi Zhang, Dong Sun
wiley   +1 more source