Results 51 to 60 of about 1,276,924 (370)
Comparative Analysis of Click Chemistry Mediated Activity-Based Protein Profiling in Cell Lysates
Molecules, 2013 Activity-based protein profiling uses chemical probes that covalently attach to active enzyme targets. Probes with conventional tags have disadvantages, such as limited cell permeability or steric hindrance around the reactive group.
Yinliang Yang +2 more
doaj +1 more source
, 2019 Click chemistry has found wide application in bioconjugation, enabling control over the site of modification in biomolecules. Demonstrations of this chemistry to construct chemically defined antibody-drug conjugates (ADCs) have increased in recent years, following studies that support benefits of homogeneity and site-specificity of drug placement on ...
Tak Ian Chio, Susan Bane
openaire +4 more sources
Recent Advances in Transition Metal-Catalyzed Ring-Opening Reaction of Aziridine
CompoundsThe smallest strained, saturated N-heterocycles, such as aziridine, can be a valuable building block in synthetic organic chemistry. Ring-opening reactions with various nucleophiles could be the most important strategy to synthesize various value-added ...
Partha Sarathi Bera +3 more
doaj +1 more source
Stable covalently photo-cross-linked poly(ionic liquid) membrane with gradient pore size
, 2017 An imidazolium-based poly(ionic liquid) is covalently cross-linked via UV light-induced thiolene (click) chemistry to yield a stable porous polyelectrolyte membrane with gradients of crosslink density and pore size distribution along its cross-section ...
Dani, Alessandro +4 more
core +1 more source
Layer-by-layer biofabrication of coronary covered stents with clickable elastin-like recombinamers [PDF]
, 2019 Producción CientíficaCoronary artery disease is the leading cause of death around the world. Endovascular stenting is the preferred treatment option to restore blood flow in the coronary arteries due to the lower perioperative morbidity when compared ...
Fernández Colino, Alicia +7 more
core +2 more sources
Metal-Free Click-Chemistry: A Powerful Tool for Fabricating Hydrogels for Biomedical Applications
Bioconjugate chemistryIncreasing interest in the utilization of hydrogels in various areas of biomedical sciences ranging from biosensing and drug delivery to tissue engineering has necessitated the synthesis of these materials using efficient and benign chemical ...
Aysun Degirmenci, R. Sanyal, A. Sanyal
semanticscholar +1 more source
Epidermal Growth Factor–PEG Functionalized PAMAM-Pentaethylenehexamine Dendron for Targeted Gene Delivery Produced by Click Chemistry [PDF]
, 2011 Aim of this study was the site-specific conjugation of an epidermal growth factor (EGF)-polyethylene glycol (PEG) chain by click chemistry onto a poly(amido amine) (PAMAM) dendron, as a key step toward defined multifunctional carriers for targeted gene ...
Balogh L. +59 more
core +1 more source
Antioxidants, 2020 To understand oxidative stress, antioxidant defense, and redox signaling in health and disease it is essential to assess protein thiol redox state. Protein thiol redox state is seldom assessed immunologically because of the inability to distinguish ...
James Nathan Cobley, Holger Husi
doaj +1 more source
Exoskeleton for Biofunctionality Protection of Enzymes and Proteins for Intracellular Delivery
Advanced NanoBiomed Research, 2021 Driven by the challenges to protect and restore biofunctionality of enzymes and proteins due to fluctuation of temperature, pH, and solvents, desired tolerances against the intracellular microenvironment can be gained via sheltering enzyme and proteins ...
Saikat Dutta
doaj +1 more source