Results 71 to 80 of about 1,290,910 (349)

In situ one-step fluorescence labeling strategy of exosomes via bioorthogonal click chemistry for real-time exosome tracking in vitro and in vivo.

Bioconjugate chemistry, 2020
Exosomes are cellular components with promising uses in cancer diagnostics and therapeutics, and their imaging and tracking are essential to study their biological properties.
Sukyung Song, M. Shim, Seungho Lim, Yujeong Moon, Suah Yang, Jinseong Kim, Yeonsun Hong, H. Y. Yoon, In‐San Kim, K. Hwang, Kwangmeyung Kim   +10 more
semanticscholar   +1 more source

Application of Click Chemistry for PET [PDF]

Current Organic Chemistry, 2013
Sharpless et al. presented, in 2001, a review in which they introduced the concept of "click chemistry". In this review a "new way" of making chemicals, with a particular emphasis on drugs, is presented. Current drugs are often based on natural products that were first extracted from plants or other organisms and then with enormous effort were ...
Bernard Feringa, Leila Mirfeizi, Philip H. Elsinga, Rudi Dierckx, Lachlan S. Campbell-Verduyn   +4 more
openaire   +4 more sources

Cloning, expression, purification, and structural modeling of the Chandipura virus matrix protein

FEBS Open Bio, EarlyView.
This research protocol offers a guide for the cloning, expression, and purification of the Chandipura virus matrix protein using E. coli. It also includes a step‐by‐step procedure for cloning, expressing, and conducting fluorescence imaging of GFP‐fused Chandipura virus matrix protein in mammalian cell lines.
Mariana Grieben
wiley   +1 more source

In situ click chemistry: from small molecule discovery to synthetic antibodies [PDF]

, 2013
Advances in the fields of proteomics, molecular imaging, and therapeutics are closely linked to the availability of affinity reagents that selectively recognize their biological targets.
Agnew, Heather D., Heath, James R., Lai, Bert T., Lee, Su Seong, Lim, Jaehong, Millward, Steven W., Nag, Arundhati, Pitram, Suresh, Rohde, Rosemary   +8 more
core  

Large-scale preparation for efficient polymer-based room-temperature phosphorescence via click chemistry

Science Advances, 2020
Room-temperature phosphorescence materials are manufactured by a facile click reaction between phosphor and polymer. To achieve efficient polymer-based room-temperature phosphorescence (RTP) materials, covalently embedding phosphors into the polymer ...
Rui Tian, Simin Xu, Qi Xu, Chao Lu
semanticscholar   +1 more source

Click reactions in chitosan chemistry [PDF]

Russian Chemical Bulletin, 2017
The review provides the first generalized and systematized information on the use of click reactions in chitosan chemistry for the preparation of novel polymers with attractive physicochemical and biological properties. The reactions of copper-catalyzed azide—alkyne cycloaddition and the click reactions of chitosan derivatives occurring in the absence ...
Kritchenkov A.S., Skorik Y.A.
openaire   +3 more sources

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

Preparing mono-dispersed liquid core PDMS microcapsules from thiol–ene–epoxy-tailored flow-focusing microfluidic devices [PDF]

, 2015
A dual-cure system based on thiol–ene and thiol–epoxy “click chemistry” reactions proved to be an effective and easy to use tool for microfluidic chips, which provides control over material properties and enables covalently bonding of chip wafers.
Daugaard, Anders Egede, Hvilsted, Søren, Mazurek, Piotr Stanislaw, Skolimowski, Maciej, Skov, Anne Ladegaard   +4 more
core   +1 more source

LIN28B Promotes Cancer Cell Dissemination and Angiogenesis

Advanced Biology, EarlyView.
Children diagnosed with high‐risk neuroblastoma have a 5‐year event‐free survival rate of less than 50% and poor outcomes after recurrence. Deregulation of the LIN28B oncogene can be addressed in these patients. Upregulation of LIN28B is shown to support the metastatic cascade.
Diana Corallo, Sara Menegazzo, Marcella Pantile, Silvia Bresolin, Carlo Zanon, Alessandro Davini, Massimiliano Mazzone, Alessandra Biffi, Sanja Aveic   +8 more
wiley   +1 more source

Synthesis of 1,4-Disubstituted Mono and Bis-triazolocarbo-acyclonucleoside Analogues of 9-(4-Hydroxybutyl)guanine by Cu(I)-Catalyzed Click Azide-Alkyne Cycloaddition [PDF]

, 2011
A series of novel mono-1,2,3-triazole and bis-1,2,3-triazole acyclonucleoside analogues of 9-(4-hydroxybutyl)guanine was prepared via copper(I)-catalyzed 1,3-dipolar cycloaddition of N-9 propargylpurine, N-1-propargylpyrimidines/as-triazine with the ...
Engels, Joachim W., Krim, Jamal, Taourirte, Mohamed   +2 more
core   +2 more sources