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Efficient DNA Click Reaction Replaces Enzymatic Ligation
Bioconjugate Chemistry, 2019We report a chemical DNA-DNA ligation method based on copper-catalyzed azide-alkyne cycloaddition (CuAAC). We demonstrate that ion addition dramatically influences the efficiency of the so-called click reaction. Even without any further additions, such as typically splint oligonucleotides for preorganization, the "click ligation" yields up to ∼83 ...
Michael Kollaschinski +5 more
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A Fluorogenic, Nucleic Acid Directed “Click” Reaction
Inorganic Chemistry, 2009A fluorogenic, nucleic acid directed, Cu(+)-catalyzed chemical reaction was developed that allows sequence-specific detection of nucleic acids at concentrations as low as 20 nM through monitoring of the increase of the fluorescence intensity. A single nucleotide mismatch in the template strand leads to the complete inhibition of this reaction.
Elmar, Jentzsch, Andriy, Mokhir
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Polymer “Clicking” by CuAAC Reactions
Macromolecular Rapid Communications, 2008AbstractThe CuAAC “click” reaction has developed as one of the most useful and widely employed reactions in ligation within polymer chemistry. This is due to the unique properties of the Cu(I) catalysis which renders the reaction quantitative even at low concentrations, orthogonal with other chemistries and extremely robust.
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Miscellaneous Click and Click-like Reactions in Polymer Science
Click chemistry approaches have directed the materials research community to access a diverse range of complex polymeric systems. Click chemistry involves exploiting the easy-to-execute chemical reactions that can be performed at ambient conditions while being efficient and rapid.Prantik Mondal +2 more
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Triple Click Reaction Strategy for Macromolecular Diversity
Macromolecular Rapid Communications, 2012AbstractThis Feature Article focuses on the rapidly emerging concept of the “triple click reactions” towards the design and synthesis of macromolecules with well‐defined topology and chemical composition, and also precise molecular weight and narrow molecular weight distribution. The term “triple click reaction” used in this feature article is based on
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การเตรียมหมึกชีวภาพจากเซริซินผ่านปฏิกิริยา thiol-ene click reaction
เซริซิน (Sericin) เป็นโปรตีนที่สร้างขึ้นโดยตัวไหม (Bombyx mori) ในการผลิตรังไหม เซริซินถูกนำมาใช้อย่างหลากหลายทางด้านยาและเครื่องสำอาง ในงานนี้ผู้วิจัยได้กราฟท์หมู่ methacryloyl ลงไปบนเซริซิน (Ser-MA) ด้วยการนำเซริซินไปละลายในพิริดีนและทำปฏิกิริยากับ methacrylic anhydride ซึ่งจะได้เปอร์เซ็นต์การแทนที่เป็น 0.36% จากการวิเคราะห์ด้วยเทคนิค ¹H NMR การกราฟท์openaire +1 more source
Multiple “Click” Reactions on Porphyrins
2010Im Rahmen der vorliegenden Arbeit wurde die 1,3-dipolare SHARPLESS Alkin-Azid Cycloaddition sehr erfolgreich auf die von JUX im Jahr 2000 vorgestellten ortho-benzylisch substituierten Tetraphenylporphyrinen übertragen. Durch diese Reaktion gelang es über 40 komplexe und anspruchsvolle Moleküle in sehr guter Ausbeute zu synthetisieren.
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