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The potential of click reactions for the synthesis of bioactive triterpenes
Bioorganic & Medicinal Chemistry Letters, 2019Click reactions between alkynes and azides using the privileged scaffold of triterpenes have been of interest for biological chemistry. Many publications deal with the synthesis of novel bioactive molecules; these conjugates have also been used for bioanalytical and diagnostic purposes.
Csuk, René, Deigner, Hans-Peter
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Polymer “Clicking” by CuAAC Reactions
Macromolecular Rapid Communications, 2008AbstractThe CuAAC “click” reaction has developed as one of the most useful and widely employed reactions in ligation within polymer chemistry. This is due to the unique properties of the Cu(I) catalysis which renders the reaction quantitative even at low concentrations, orthogonal with other chemistries and extremely robust.
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Surface immobilization of biomolecules by click sulfonamide reaction
Chemical Communications, 2008Alkyne-modified biomolecules can be immobilized site- and chemoselectively on sulfonylazide slides under very mild conditions by means of the click sulfonamide reaction.
Govindaraju, T. +6 more
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Kinugasa Reaction under Click Chemistry Conditions
Synlett, 2007AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A. Basak +3 more
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Trimerization of β-cyclodextrin through the click reaction
Carbohydrate Polymers, 2013Triprop-2-ynyl benzene-1,3,5-tricarboxylate (A) is synthesized by the reaction of 1,3,5-benzenetricarbonyl trichloride with propargyl alcohol and (A) is clicked with mono-6-deoxy-6-azido-β-cyclodextrin (N3-β-CD) in the presence of copper(I) bromide catalyst. N3-β-CD has been prepared from β-cyclodextrin (β-CD) on treatment with toluenesulfonyl chloride
Kranthikumar, Tungala +2 more
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Bioorthogonal Click and Release Reaction of Iminosydnones with Cycloalkynes
Angewandte Chemie, 2017AbstractWe report the discovery of a new bioorthogonal click‐and‐release reaction involving iminosydnones and strained alkynes. This transformation leads to two products resulting from the ligation and fragmentation of iminosydnones under physiological conditions. Optimized iminosydnones were successfully used to design innovative cleavable linkers for
Bernard, Sabrina +14 more
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Miscellaneous Click and Click-like Reactions in Polymer Science
Click chemistry approaches have directed the materials research community to access a diverse range of complex polymeric systems. Click chemistry involves exploiting the easy-to-execute chemical reactions that can be performed at ambient conditions while being efficient and rapid.Prantik Mondal +2 more
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Triple Click Reaction Strategy for Macromolecular Diversity
Macromolecular Rapid Communications, 2012AbstractThis Feature Article focuses on the rapidly emerging concept of the “triple click reactions” towards the design and synthesis of macromolecules with well‐defined topology and chemical composition, and also precise molecular weight and narrow molecular weight distribution. The term “triple click reaction” used in this feature article is based on
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Capsules for Automated Azide–Alkyne Click Reactions
Organic LettersThe development of an automated and reproducible process for copper-mediated click reactions of alkynes and azides into 1,4-disubstituted 1,2,3-triazole products is described. This method utilizes prepacked capsules that contain all necessary reagents and materials for the reaction and purification processes.
Anna Konopka +4 more
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