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Click reactions with functional sphingolipids
Biological Chemistry, 2018Abstract Sphingolipids and glycosphingolipids can regulate cell recognition and signalling. Ceramide and sphingosine-1-phosphate are major players in the sphingolipid pathways and are involved in the initiation and regulation of signalling, apoptosis, stress responses and infection.
Julian, Fink, Jürgen, Seibel
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A laccase-catalysed tyrosine click reaction
Organic & Biomolecular Chemistry, 2020The tyrosine click reaction of peptides/proteins with the tyrosine modification reagent, N-methyl luminol, was catalysed by a laccase in the presence of molecular oxygen (O2) at 37 °C.
Shinichi Sato +2 more
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Click Reactions with Nitroxides
Synthesis, 2009Copper-catalyzed azide-alkyne 1,3-dipolar cycloadditions (CuAAC) with paramagnetic azide and alkyne building blocks are described. This method provides a route to the synthesis of complex spin-labeled molecules such as amino acids, carbohydrates, drug molecules and biradicals.
Kálmán Hideg +2 more
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Current Organic Chemistry, 2016
The Diels-Alder reactions can be classified as click reactions because of their simplicity and high yields. The Diels-Alder click reactions have been used for the preparation of complex macromolecules, such as hydrogels and polymers and also for labeling of various biological targets.
Dajana Ga.so-Soka.c, Marija Stivojevi.c
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The Diels-Alder reactions can be classified as click reactions because of their simplicity and high yields. The Diels-Alder click reactions have been used for the preparation of complex macromolecules, such as hydrogels and polymers and also for labeling of various biological targets.
Dajana Ga.so-Soka.c, Marija Stivojevi.c
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Clusters for alkyne-azide click reactions
Dalton Transactions, 2010The clusters Ti(6)O(4)(OPr)(8)(OOC(CH(2))(2)C[triple bond]CH)(8) and [Zr(6)O(4)(OH)(4)(OOC(CH(2))(3)C[triple bond]CH)(12)](2) with acetylenic carboxylate ligands were prepared and structurally characterized in solution and in the crystalline state. Model reactions showed that they are suitable candidates for the formation of cluster-based inorganic ...
Philipp, Heinz +4 more
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Chemoselective derivatization of a bionanoparticle by click reaction and ATRP reaction
Chemical Communications, 2007Horse spleen apoferritin, the hollow protein shell derived from ferritin, a special biological nanoparticle, can be chemoselectively modified at the lysine residues, which affords a robust scaffold for further chemical reactions including Cu(i)-catalyzed azide-alkyne cycloaddition reaction and atom transfer radical polymerization reaction.
Qingbing, Zeng +5 more
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Intramolecular Nitrone Interrupted Click Reaction
Organic LettersWe document the intramolecular interception of a Cu-catalyzed azidoalkyne cycloaddition employing a suitably placed nitrone group, providing a simple route to the unprecedented spiro-polyheterocyclic scaffold. The reaction is comprised of a Cu-catalyzed [3 + 2]-cycloaddition of (2-azidoaryl)isatogen with a terminal alkyne and the intramolecular ...
Tejas A. Pothi, Chepuri V. Ramana
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Heterovalent Click Reactions on DNA Origami
Bioconjugate ChemistryNucleic acid nanoparticles (NANPs) fabricated by using the DNA origami method have broad utility in materials science and bioengineering. Their site-specific, heterovalent functionalization with secondary molecules such as proteins or fluorophores is a unique feature of this technology that drives its utility.
Grant A. Knappe +4 more
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Radical-mediated click-clip reactions
ScienceClick reactions, which are characterized by rapid, high-yielding, and highly selective coupling of two reaction partners, are powerful tools in synthesis but are rarely reversible. Innovative strategies that reverse such couplings in a precise and on-demand manner, enabling a click-clip sequence, would greatly expand the technique’s versatility. Herein,
Jiantao Zhao +6 more
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Two-color emissive probes for click reactions
Chem. Commun., 2014CuAAC is visualized using a BODIPY reaction system by the bathochromic shift of the fluorescence wavelength in ensemble and microscopy experiments. Reaction progress is correlated with chromophore elongation fading out disturbing background fluorescence.
Marcel, Wirtz +6 more
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