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Angewandte Chemie International Edition, 2013
AbstractSpatial and temporal control over chemical and biological processes, both in terms of “tuning” products and providing site‐specific control, is one of the most exciting and rapidly developing areas of modern science. For synthetic chemists, the challenge is to discover and develop selective and efficient reactions capable of generating useful ...
Mehmet Atilla, Tasdelen, Yusuf, Yagci
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AbstractSpatial and temporal control over chemical and biological processes, both in terms of “tuning” products and providing site‐specific control, is one of the most exciting and rapidly developing areas of modern science. For synthetic chemists, the challenge is to discover and develop selective and efficient reactions capable of generating useful ...
Mehmet Atilla, Tasdelen, Yusuf, Yagci
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A Photoinduced, Benzyne Click Reaction
Organic Letters, 2014The [3 + 2] cycloaddition of azides and alkynes has proven invaluable across numerous scientific disciplines for imaging, cross-linking, and site-specific labeling among many other applications. We have developed a photoinitiated, benzyne-based [3 + 2] cycloaddition that is tolerant of a variety of functional groups as well as polar, protic solvents ...
Adam W, Gann +5 more
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Click reactions with functional sphingolipids
Biological Chemistry, 2018Abstract Sphingolipids and glycosphingolipids can regulate cell recognition and signalling. Ceramide and sphingosine-1-phosphate are major players in the sphingolipid pathways and are involved in the initiation and regulation of signalling, apoptosis, stress responses and infection.
Julian, Fink, Jürgen, Seibel
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Strain-Promoted Cycloaddition of Cyclopropenes with o-Quinones: A Rapid Click Reaction [PDF]
Angewandte Chemie - International Edition, 2018 Novel click reactions are of continued interest in fields as diverse as bio-conjugation, polymer science and surface chemistry. Qualification as a proper "click" reaction requires stringent criteria, including fast kinetics and high conversion, to be met.
Han Zuilhof +2 more
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Click Reactions with Nitroxides
Synthesis, 2009Copper-catalyzed azide-alkyne 1,3-dipolar cycloadditions (CuAAC) with paramagnetic azide and alkyne building blocks are described. This method provides a route to the synthesis of complex spin-labeled molecules such as amino acids, carbohydrates, drug molecules and biradicals.
Kálmán Hideg +2 more
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Current Organic Chemistry, 2016
The Diels-Alder reactions can be classified as click reactions because of their simplicity and high yields. The Diels-Alder click reactions have been used for the preparation of complex macromolecules, such as hydrogels and polymers and also for labeling of various biological targets.
Dajana Ga.so-Soka.c, Marija Stivojevi.c
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The Diels-Alder reactions can be classified as click reactions because of their simplicity and high yields. The Diels-Alder click reactions have been used for the preparation of complex macromolecules, such as hydrogels and polymers and also for labeling of various biological targets.
Dajana Ga.so-Soka.c, Marija Stivojevi.c
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Clusters for alkyne-azide click reactions
Dalton Transactions, 2010The clusters Ti(6)O(4)(OPr)(8)(OOC(CH(2))(2)C[triple bond]CH)(8) and [Zr(6)O(4)(OH)(4)(OOC(CH(2))(3)C[triple bond]CH)(12)](2) with acetylenic carboxylate ligands were prepared and structurally characterized in solution and in the crystalline state. Model reactions showed that they are suitable candidates for the formation of cluster-based inorganic ...
Philipp, Heinz +4 more
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Chemoselective derivatization of a bionanoparticle by click reaction and ATRP reaction
Chemical Communications, 2007Horse spleen apoferritin, the hollow protein shell derived from ferritin, a special biological nanoparticle, can be chemoselectively modified at the lysine residues, which affords a robust scaffold for further chemical reactions including Cu(i)-catalyzed azide-alkyne cycloaddition reaction and atom transfer radical polymerization reaction.
Qingbing, Zeng +5 more
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Bioorthogonal Click and Release Reaction of Iminosydnones with Cycloalkynes
Angewandte Chemie - International Edition, 2017AbstractWe report the discovery of a new bioorthogonal click‐and‐release reaction involving iminosydnones and strained alkynes. This transformation leads to two products resulting from the ligation and fragmentation of iminosydnones under physiological conditions. Optimized iminosydnones were successfully used to design innovative cleavable linkers for
Frédéric Taran +2 more
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Intramolecular Nitrone Interrupted Click Reaction
Organic LettersWe document the intramolecular interception of a Cu-catalyzed azidoalkyne cycloaddition employing a suitably placed nitrone group, providing a simple route to the unprecedented spiro-polyheterocyclic scaffold. The reaction is comprised of a Cu-catalyzed [3 + 2]-cycloaddition of (2-azidoaryl)isatogen with a terminal alkyne and the intramolecular ...
Tejas A. Pothi, Chepuri V. Ramana
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