Results 41 to 50 of about 354,979 (259)

How atmospheric humidity drives the outgoing longwave radiation–surface temperature relationship and inter-model spread

Environmental Research Letters, 2023
The Earth’s global radiation budget depends critically on the relationship between outgoing longwave radiation (OLR) and surface temperature ( $T_\mathrm{s}$ ).
Jing Feng, David Paynter, Chenggong Wang, Raymond Menzel   +3 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Multicentennial Variability Driven by Salinity Exchanges Between the Atlantic and the Arctic Ocean in a Coupled Climate Model

Journal of Advances in Modeling Earth Systems, 2021
The IPSL‐CM6‐LR atmosphere‐ocean coupled model exhibits a pronounced multicentennial variability of the Atlantic meridional overturning circulation (AMOC), driven by delayed freshwater accumulation and release in the Arctic.
Weimin Jiang, Guillaume Gastineau, Francis Codron   +2 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Sustainable bioplastics manufacturing from renewable sources

FEBS Open Bio, EarlyView.
Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto, Marika Avitabile, Michela Famiglietti, Talayeh Kordjazi, Marzieh Moosavi‐Nasab, Odile F. Restaino, Loredana Mariniello   +6 more
wiley   +1 more source

A fast and spatialized urban weather generator for long-term urban studies at the city-scale.

Frontiers in Earth Science, 2015
In order to make urban climate predictions at the city-scale and on long term experiment accessible to communities such as building engineers or urban planner, a method to calculate meteorological forcing for surface models is presented.
Julien eLe Bras, Valéry eMasson
doaj   +1 more source

A global dataset on subgrid land surface climate (2015–2100) from the Community Earth System Model

Geoscience Data Journal, 2023
Subgrid data from earth system models are a powerful, yet underutilized, data resource for investigating the climatic impacts of land use and land cover change (LULCC). In this paper, we describe a global dataset on subgrid land surface climate variables
Keer Zhang, Xuhui Lee, Natalie M. Schultz, Lei Zhao, Chunyang He, Qingxu Huang, Zhifeng Liu, Haoran Chu, Jiayu Zhao   +8 more
doaj   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Contributions of Natural and Anthropogenic Forcing Agents to the Early 20th Century Warming

Frontiers in Earth Science, 2018
The warming observed in the early 20th century (1910–1940) is one of the most intriguing and less understood climate anomalies of the 20th century.
Tatiana Egorova, Eugene Rozanov, Eugene Rozanov, Pavle Arsenovic, Thomas Peter, Werner Schmutz   +5 more
doaj   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source