Results 61 to 70 of about 473,538 (324)
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
Affordance Realization in Climbing: Learning and Transfer
Frontiers in Psychology, 2018 The aim of this study was to investigate how the affordances of an indoor climbing wall changed for intermediate climbers following a period of practice during which hold orientation was manipulated within a learning and transfer protocol.
Ludovic Seifert +5 more
doaj +1 more source
Pacific lamprey inspired climbing
Bioinspiration & Biomimetics, 2023 Abstract Snakes and their bio-inspired robot counterparts have demonstrated locomotion on a wide range of terrains. However, dynamic vertical climbing is one locomotion strategy that has received little attention in the existing snake robotics literature.
Brian Van Stratum +2 more
openaire +3 more sources
Design opportunities for wearable devices in learning to climb [PDF]
, 2016 In this paper, we present a field study on the learning of climbing aimed at defining the design space of wearable devices to support beginners. Three main findings have emerged from our study.
Beyer H. +10 more
core +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Frontiers in Pain Research, 2023 This study evaluated climbing in mice as a tool to assess the expression and treatment of pain-related behavioral depression in male and female ICR mice.
Edna J. Santos +3 more
doaj +1 more source
Search Heuristics, Case-Based Reasoning and Software Project Effort Prediction [PDF]
, 2002 This paper reports on the use of search techniques to help optimise a case-based reasoning (CBR) system for predicting software project effort. A major problem, common to ML techniques in general, has been dealing with large numbers of case features ...
Hart, J, Kirsopp, C, Shepperd, M J
core +1 more source
Effective Fitness Landscapes for Evolutionary Systems
, 1999 In evolution theory the concept of a fitness landscape has played an important role, evolution itself being portrayed as a hill-climbing process on a rugged landscape.
Stephens, C. R.
core +2 more sources
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Sport and adventure in the Pădurea Craiului Mountains [PDF]
GeoSport for Society, 2019 The term of tourist product, as it was understood in the first decade after December, has undergone an important change of meaning, in the age of today’s tourist.
Varodi Mihaela OLĂU +3 more
doaj +1 more source