Cerebellar climbing fibers encode expected reward size [PDF]
eLife, 2019 Climbing fiber inputs to the cerebellum encode error signals that instruct learning. Recently, evidence has accumulated to suggest that the cerebellum is also involved in the processing of reward.
Noga Larry +3 more
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Climbing Fibers Provide Graded Error Signals in Cerebellar Learning [PDF]
Frontiers in Systems Neuroscience, 2019 The cerebellum plays a critical role in coordinating and learning complex movements. Although its importance has been well recognized, the mechanisms of learning remain hotly debated.
Yunliang Zang, Erik De Schutter
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Cerebellar climbing fibers multiplex movement and reward signals during a voluntary movement task in mice [PDF]
Communications Biology, 2023 Cerebellar climbing fibers convey sensorimotor information and their errors, which are used for motor control and learning. Furthermore, they represent reward-related information.
Koji Ikezoe +7 more
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Developmental Rewiring between Cerebellar Climbing Fibers and Purkinje Cells Begins with Positive Feedback Synapse Addition [PDF]
Cell Reports, 2019 Summary: During postnatal development, cerebellar climbing fibers alter their innervation strengths onto supernumerary Purkinje cell targets, generating a one-to-few connectivity pattern in adulthood.
Alyssa Michelle Wilson +6 more
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Climbing fiber burst size and olivary sub-threshold oscillations in a network setting. [PDF]
PLoS Computational Biology, 2012 The inferior olivary nucleus provides one of the two main inputs to the cerebellum: the so-called climbing fibers. Activation of climbing fibers is generally believed to be related to timing of motor commands and/or motor learning.
Jornt R De Gruijl +3 more
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Non-synaptic signaling from cerebellar climbing fibers modulates Golgi cell activity [PDF]
eLife, 2017 Golgi cells are the principal inhibitory neurons at the input stage of the cerebellum, providing feedforward and feedback inhibition through mossy fiber and parallel fiber synapses.
Angela K Nietz +4 more
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Classical conditioning drives learned reward prediction signals in climbing fibers across the lateral cerebellum [PDF]
eLife, 2019 Classical models of cerebellar learning posit that climbing fibers operate according to a supervised learning rule to instruct changes in motor output by signaling the occurrence of movement errors.
William Heffley, Court Hull
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Developmental Easing of Short-Term Depression in “Winner” Climbing Fibers [PDF]
Frontiers in Cellular Neuroscience, 2019 The postnatal development of cerebellar climbing fiber (CF) to Purkinje neuron (PN) synapses is characterized by a substantial pruning during the first 3 weeks after birth, switching from multiple- to single-CF innervation.
Christina Pätz +2 more
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The spiny relationship between parallel fibers, climbing fibers, and Purkinje cells [PDF]
Frontiers in PhysiologyCerebellar Purkinje cells are one of the most complex neurons in the central nervous system and are well known for their extensive dendritic tree dotted by dendritic spines.
Stefano Masoli +4 more
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Beyond all-or-nothing climbing fibers: graded representation of teaching signals in Purkinje cells [PDF]
Frontiers in Neural Circuits, 2013 Arguments about the function of the climbing fiber input to the cerebellar cortex have fueled a rabid debate that started over forty years ago, and continues to polarize the field to this day. The origin of the controversy can be traced back to 1969, the
Farzaneh eNajafi, Javier F Medina
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