Intraburst and Interburst Signaling by Climbing Fibers [PDF]
The Journal of Neuroscience, 2007 Although cerebellar Purkinje cell complex spikes occur at low frequency (∼1/s), each complex spike is often associated with a high-frequency burst (∼500/s) of climbing fiber spikes. We examined the possibility that signals are present within the climbing fiber bursts.
Jun, Maruta +2 more
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Gating of neural error signals during motor learning
eLife, 2014 Cerebellar climbing fiber activity encodes performance errors during many motor learning tasks, but the role of these error signals in learning has been controversial.
Rhea R Kimpo +4 more
doaj +1 more source
Widespread state-dependent shifts in cerebellar activity in locomoting mice. [PDF]
PLoS ONE, 2012 Excitatory drive enters the cerebellum via mossy fibers, which activate granule cells, and climbing fibers, which activate Purkinje cell dendrites.
Ilker Ozden +4 more
doaj +1 more source
Climbing fiber regulation of spontaneous Purkinje cell activity and cerebellum-dependent blink responses [PDF]
, 2016 It has been known for a long time that GABAergic Purkinje cells in the cerebellar cortex, as well as their target neurons in the cerebellar nuclei, are spontaneously active.
Bengtsson, F. (Fredrik) +2 more
core +3 more sources
Bidirectional Parallel Fiber Plasticity in the Cerebellum under Climbing Fiber Control [PDF]
Neuron, 2004 Cerebellar parallel fiber (PF)-Purkinje cell (PC) synapses can undergo postsynaptically expressed long-term depression (LTD) or long-term potentiation (LTP) depending on whether or not the climbing fiber (CF) input is coactivated during tetanization. Here, we show that modifications of the postsynaptic calcium load using the calcium chelator BAPTA or ...
Coesmans, Michiel +3 more
openaire +2 more sources
Inhibition gates supralinear Ca2+ signaling in Purkinje cell dendrites during practiced movements
eLife, 2018 Motor learning involves neural circuit modifications in the cerebellar cortex, likely through re-weighting of parallel fiber inputs onto Purkinje cells (PCs).
Michael A Gaffield +4 more
doaj +1 more source
Supervised learning with complex spikes and spike-timing-dependent plasticity. [PDF]
PLoS ONE, 2014 One distinctive feature of Purkinje cells is that they have two types of discharge: in addition to simple spikes they fire complex spikes in response to input from the climbing fibers.
Conor Houghton
doaj +1 more source
The cerebellum could solve the motor error problem through error increase prediction [PDF]
, 2015 We present a cerebellar architecture with two main characteristics. The first one is that complex spikes respond to increases in sensory errors. The second one is that cerebellar modules associate particular contexts where errors have increased in the ...
O'Reilly, Randall C. +1 more
core +2 more sources
Cerebellar encoding of multiple candidate error cues in the service of motor learning [PDF]
, 2014 or learning to occur through trial and error, the nervous system must effectively detect and encode performance errors. To examine this process, we designed a set of oculomotor learning tasks with more than one visual object providing potential error ...
Guo, Christine C. +2 more
core +1 more source
Optical Fiber-Based Recording of Climbing Fiber Ca2+ Signals in Freely Behaving Mice
Biology, 2022 The olivocerebellar circuitry is important to convey both motor and non-motor information from the inferior olive (IO) to the cerebellar cortex. Several methods are currently established to observe the dynamics of the olivocerebellar circuitry, largely ...
Jiechang Tang +8 more
doaj +1 more source