Results 111 to 120 of about 677,579 (283)

Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome

Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja, Anuja Sule, Katie Ann McMullen, Aditi Dhir, Matthew D. Hall, Heather J. McCrea, Sakir Humayun Gultekin, Mustafa Tekin, Bradley Gampel   +8 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

The Effect of Bariatric Surgery on Diabetic Retinopathy: Good, Bad, or Both? [PDF]

, 2016
Bariatric surgery, initially intended as a weight-loss procedure, is superior to standard lifestyle intervention and pharmacological therapy for type 2 diabetes in obese individuals.
Docherty, NG, Gorman, DM, Le Roux, CW
core   +3 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Improvement in Functional Outcome from 6 to 12 Months After Moderate and Severe Traumatic Brain Injury Is Frequent, But May Not Be Detected With the Glasgow Outcome Scale Extended

Neurotrauma Reports
The aims of this study were (1) to report outcome and change in outcome in patients with moderate and severe traumatic brain injury (mo/sTBI) between 6 and 12 months post-injury as measured by the Glasgow Outcome Scale Extended (GOSE), (2) to explore if ...
Rabea Iris Pantelatos, Jonas Stenberg, Turid Follestad, Oddrun Sandrød, Cathrine Elisabeth Einarsen, Anne Vik, Toril Skandsen   +6 more
doaj   +3 more sources

Withdrawal from treatment as an outcome in the Isolde study of COPD [PDF]

, 2003
Objectives: To investigate the determinants of patient withdrawal from our study, and the effect of these withdrawals on the outcome of treatment with inhaled corticosteroids in patients with COPD.
American Thoracic Society, Brazier, Burge, Chervinsky, Davies, Greening, Jarad, Jones, Jones, Jones, Jones, Lisa Willits, Meecham-Jones, Nelson, Niewoehner, Osman, P. Sherwood Burge, Paul W. Jones, Pauwels, Pauwels, Pauwels, Peter M.A. Calverley, Sally Spencer, Seemungal, Spencer, The Lung Health Study Research Group, Vestbo, Ware   +27 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Pneumoventricle of Unknown Origin. A Personal Experience and Literature Review of a Clinical Enigma [PDF]

, 2019
Pneumocephalus (PC) is an uncommon and life-threatening neurological condition. Air within the ventricular system of the brain is also known as Pneumoventricle (PV). It requires emergency treatments to prevent catastrophic neurological outcomes.
Armocida, Daniele, Frati, Alessandro, Miscusi, Massimo, Paglia, Francesco, Pesce, Alessandro, Raco, Antonino   +5 more
core   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Early in-hospital clinical deterioration is not predicted by severity of illness, functional status, or comorbidity

International Journal of General Medicine, 2017
Janice Wang,1 Stella S Hahn,1 Myriam Kline,2 Rubin I Cohen1 1Division of Pulmonary, Critical Care and Sleep Medicine, Hofstra Northwell School of Medicine, New Hyde Park, 2Biostatistics Unit, Feinstein Institute for Medical Research, Northwell Health ...
Wang J, Hahn SS, Kline M, Cohen RI
doaj