Results 81 to 90 of about 2,660,626 (386)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Rapid Detection of Leishmania infantum Infection in Dogs: Comparative Study Using an Immunochromatographic Dipstick Test, Enzyme-Linked Immunosorbent Assay, and PCR [PDF]

, 2002
Current zoonotic visceral leishmaniasis (ZVL) control programs in Brazil include the culling of Leishmania infantum-infected reservoir dogs, a strategy that has failed to prevent a rise of canine and human ZVL cases over the past decade.
Bruce Alex, Bruce Alex, Clive R. Davies, Clive R. Davies, J. Clin Microbiol, Richard Reithinger, Richard Reithinger, Rupert J. Quinnell, Rupert J. Quinnell   +8 more
core   +3 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

A preliminary serological study of Trypanosoma evansi and Trypanosoma lewisi in a Chinese human population [PDF]

, 2018
Trypanosoma evansi, known as an animal trypanosome, is widely distributed in many countries of Africa, Asia and South America; it causes significant economic loss in these countries.
Courtois, Patrick, Desquesnes, Marc, Gao, Jiang-Mei, Jittapalapong, Sathaporn, Li, Su-Jin, Lun, Zhao-Rong, Truc, Philippe, Vincendeau, Philippe, Zhang, Xuan   +8 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Nonalcoholic Fatty Liver Disease in Canadian First Nations and Non-First Nations Patients

Canadian Journal of Gastroenterology and Hepatology, 2016
Background. Features of nonalcoholic fatty liver disease (NAFLD) have yet to be described in the Canadian First Nations (FN) population. The aim of this study was to compare the prevalence, severity, and outcome of NAFLD in FN versus non-FN patients at ...
Julia Uhanova, Gerald Minuk, Federico Lopez Ficher, Natasha Chandok   +3 more
doaj   +1 more source

Comparison of Diagnostic Methods in Hospitalized Patients With Brucellosis in Iran [PDF]

Diagnosis of brucellosis is based on clinical symptoms and positive laboratory results. Because specificity of the serology tests is not satisfactory and sensitivity of the culture is low, polymerase chain reaction (PCR) can be an alternative method in ...
امیرزرگر, علی اکبر, جعفری, سیروس, حاجيا, مسعود, حسیبی, مهرداد, مالک نژاد, پرویز, پیری دوگاهه, هادی   +5 more
core   +1 more source

Performance of Competitive and Indirect Enzyme-Linked Immunosorbent Assays, Gel Immunoprecipitation with Native Hapten Polysaccharide, and Standard Serological Tests in Diagnosis of Sheep Brucellosis

Clinical Diagnostic Laboratory Immunology, 1999
Competitive and standard enzyme-linked immunosorbent assays (ELISAs), rose bengal (RB), complement fixation, and agar gel immunoprecipitation with native hapten (AGID-NH) were compared by using sera from Brucella-free, Brucella melitensis-infected, and B.
C. Marín, E. Moreno, I. Moriyón, R. Díaz, J. Blasco   +4 more
semanticscholar   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Fabry disease screening in kidney transplant patients: A single-center study in Türkiye

Gülhane Tıp Dergisi, 2022
Aims:This study aimed to screen for Fabry disease in adult kidney transplant patients at a nephrology clinic in Türkiye.Methods:This cross-sectional, single-center study prospectively enrolled kidney transplant recipients regardless of the etiology of ...
Şeyma Meriç Aktaş, Gülay Ulusal Okyay, Tamer Selen, Kadir Gökhan Atılgan, Mehmet Deniz Ayli   +4 more
doaj   +1 more source