Results 91 to 100 of about 9,220,792 (417)

The solution supramolecular structure of α2 → 8 polysialic acid suggests a structural cause for its low immunogenicity

FEBS Letters, EarlyView.
α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley   +1 more source

A phase III randomized crossover trial of plerixafor versus G-CSF for treatment of WHIM syndrome

The Journal of Clinical Investigation, 2023
BACKGROUND Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome is a primary immunodeficiency disorder caused by heterozygous gain-of-function CXCR4 mutations.
David H. McDermott, Daniel Velez, Elena Cho, Edward W. Cowen, John J. DiGiovanna, Diana V. Pastrana, Christopher B. Buck, Katherine R. Calvo, Pamela J. Gardner, Sergio D. Rosenzweig, Pamela Stratton, Melissa A. Merideth, H. Jeffrey Kim, Carmen Brewer, James D. Katz, Douglas B. Kuhns, Harry L. Malech, Dean Follmann, Michael P. Fay, Philip M. Murphy   +19 more
doaj   +1 more source

Clinical Significance of Propionibacterium acnes in the Formation of Noncaseating Epithelioid-Cell Granulomas of the Mediastinal Lymph Nodes and Lung in Patients with Lung Cancer:Differential Diagnosis Between Sarcoid Reactions and Sarcoidosis [PDF]

, 2013
Objectives:Sarcoidosis is a systemic noncaseating epithelioid-cell granulomatous disease of unknown origin.Granulomas occurring around malignant tumors and regional lymph nodes can be caused by sarcoid reactions.The mechanisms underlying sarcoidosis and ...
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Hirokuni Hirata, Kumiya Sugiyama, Mineaki Watanabe, Naoya Ikeda, Naruo Yoshida, Shogo Onishi, Takeshi Fukuda, Yasutsugu Fukushima, Yushi Nomura   +17 more
core   +1 more source

Racotumomab: an anti=idiotype vaccine related to N=glycolyl=containing=gangliosides: Preclinical and clinical data [PDF]

, 2012
Neu-glycolyl (NeuGc)-containing gangliosides are attractive targets for immunotherapy with anti-idiotype mAbs, because these glycolipids are not normal components of the cytoplasmic membrane in humans, but their expression has been demonstrated in ...
Alonso, Daniel Fernando, Gabri, Mariano Rolando, Gomez, Daniel Eduardo, Gomez, Roberto E., Hernandez, Ana M., Macias, Amparo, Montero, Enrique, Vazquez, Ana M.   +7 more
core   +2 more sources

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

A randomized, phase II study of sequential belimumab and rituximab in primary Sjögren’s syndrome

JCI Insight, 2022
BACKGROUND Primary Sjögren’s syndrome (pSS) is characterized by B cell hyperactivity and elevated B-lymphocyte stimulator (BLyS). Anti-BLyS treatment (e.g., belimumab) increases peripheral memory B cells; decreases naive, activated, and plasma B cell ...
Xavier Mariette, Francesca Barone, Chiara Baldini, Hendrika Bootsma, Kenneth L. Clark, Salvatore De Vita, David H. Gardner, Robert B. Henderson, Michael Herdman, Karoline Lerang, Prafull Mistry, Raj Punwaney, Raphaele Seror, John Stone, Paul L.A. van Daele, André van Maurik, Nicolas Wisniacki, David A. Roth, Paul Peter Tak   +18 more
doaj   +1 more source

A Simple Cellular Automaton Model for Influenza A Viral Infections [PDF]

Journal of Theoretical Biology, 232(2), 21 January 2005, pp. 223-234, 2004
Viral kinetics have been extensively studied in the past through the use of spatially homogeneous ordinary differential equations describing the time evolution of the diseased state. However, spatial characteristics such as localized populations of dead cells might adversely affect the spread of infection, similar to the manner in which a counter-fire ...
arxiv   +1 more source

Current state and future of pediatric allergology in Europe: A road map [PDF]

, 2018
The history of pediatric allergology (PA) in Europe is relatively youthful, dating back to 1984, when a small group of pediatricians founded the European Working Group on Pediatric Allergy and Immunology—later giving rise to ESPACI (European Society on ...
Alvaro Lozano, M. (Montserrat), Atanaskovic-Markovic, M. (Marina), Baghdasaryan, A. (Astghik), Beyer, K. (Kirsten), DuToit, G. (George), Eigenmann, P.A. (Philippe), Gerth van Wijk, R. (Roy), Høst, A. (Arne), Ingemann, L. (Lars), Kivistö, J.E. (Juho E.), Lopes dos Santos, J.M. (Jose Manuel), Maggina, P. (Paraskevi), Melén, E. (Erik), Muraro, A. (Antonella), Nieto, A. (Antonio), O'Hourihane, J. (Jonathan), Pajno, G. (G.), Rose, K. (Klaus), Réthy, L.A. (Lagos A.), Sackesen, C. (Cansin), Sanchez Garcia, S. (Silvia), Schmid-Grendelmeier, P. (Peter), Tsilochristou, O. (Olympia), Uysal, P. (Pinar), Valovirta, E. (Erkka), van der Poel, L.-A. (Lauri-Ann), Wahn, U. (Ulrich), Wickman, M., Zolkipli, Z. (Zaraquiza)   +28 more
core   +7 more sources

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Inhaled Corticosteroids and Placebo Treatment Effects in Adult Patients With Cough : A Systematic Review and Meta-analysis [PDF]

, 2019
Copyright © 2019 The Korean Academy of Asthma, Allergy and Clinical Immunology · The Korean Academy of Pediatric Allergy and Respiratory Disease.Peer reviewedPublisher ...
Cho, Sang Heon, Kim, Hyun Jung, Lee, Byung Jae, Lee, Ji Hyang, Lee, Seung Eun, Morice, Alyn H, Price, David, Song, Woo Jung   +7 more
core   +2 more sources