Results 21 to 30 of about 486,600 (333)

Immunological profiles of patients from endemic areas infected with Schistosoma mansoni

Memorias do Instituto Oswaldo Cruz, 1992
Crude extracts of eggs (SEA) adult worms (SWAP) or cercariae (Cerc) have been used to stimulate Peripheral Blood Mononuclear cells (PBMC) and have provided rather distinct profiles of responses in different types of patients. In genenral it is clear that
Giovanni Gazzinelli, Iramaya R. C. Viana, Lilian M. G. Bahia-Oliveira, Alda Maria S. Silveira, Claudia Carvalho Queiroz, Omar dos Santos Carvalho, Cristiano L. Massara, Lucia A. O. Fraga, Daniel G. Colley, Rodrigo Correa Oliveira   +9 more
doaj   +1 more source

Evaluation of Subjects Experiencing Allergic Reactions to Non-Steroidal Anti-Inflammatory Drugs: Clinical Characteristics and Drugs Involved

Frontiers in Pharmacology, 2020
Non-steroidal anti-inflammatory drugs (NSAIDs), the most commonly prescribed and consumed medicines worldwide, are the main triggers of drug hypersensitivity reactions (DHRs).
Natalia Pérez-Sánchez, Natalia Pérez-Sánchez, Inmaculada Doña, Gador Bogas, María Salas, Almudena Testera, José A. Cornejo-García, María J. Torres, María J. Torres, María J. Torres, María J. Torres   +10 more
doaj   +1 more source

Smooth and probabilistic PARAFAC model with auxiliary covariates [PDF]

arXiv, 2021
In immunological and clinical studies, matrix-valued time-series data clustering is increasingly popular. Researchers are interested in finding low-dimensional embedding of subjects based on potentially high-dimensional longitudinal features and investigating relationships between static clinical covariates and the embedding.
arxiv  

A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1985-1998, December 2022., 2022
Abstract Objectives Peripheral neuropathy is a relevant dose‐limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity of neurotoxicity often leads to dose reduction or even premature cessation of chemotherapy.
Aina Calls, Abel Torres‐Espin, Marc Tormo, Laura Martínez‐Escardó, Núria Bonet, Ferran Casals, Xavier Navarro, Víctor J. Yuste, Esther Udina, Jordi Bruna   +9 more
wiley   +1 more source

Langerhans-type dendritic cells electroporated with TRP-2 mRNA stimulate cellular immunity against melanoma: Results of a phase I vaccine trial

OncoImmunology, 2018
Purpose: We conducted a phase I vaccine trial to determine safety, toxicity, and immunogenicity of autologous Langerhans-type dendritic cells (LCs), electroporated with murine tyrosinase-related peptide-2 (mTRP2) mRNA in patients with resected AJCC stage
David J. Chung, Richard D. Carvajal, Michael A. Postow, Sneh Sharma, Katherine B. Pronschinske, Justin A. Shyer, Shahnaz Singh-Kandah, Mark A. Dickson, Sandra P. D'Angelo, Jedd D. Wolchok, James W. Young   +10 more
doaj   +1 more source

Recognizing early MRI signs (or their absence) is crucial in diagnosing metachromatic leukodystrophy

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1999-2009, December 2022., 2022
Abstract Objectives Metachromatic leukodystrophy (MLD) has characteristic white matter (WM) changes on brain MRI, which often trigger biochemical and genetic confirmation of the diagnosis. In early or pre‐symptomatic disease stages, these typical MRI changes might be absent, hampering early diagnosis.
Daphne H. Schoenmakers, Shanice Beerepoot, Ingeborg Krägeloh‐Mann, Saskia Elgün, Benjamin Bender, Marjo S. van der Knaap, Nicole I. Wolf, Samuel Groeschel   +7 more
wiley   +1 more source

Deep Historical Borrowing Framework to Prospectively and Simultaneously Synthesize Control Information in Confirmatory Clinical Trials with Multiple Endpoints [PDF]

, 2020
In current clinical trial development, historical information is receiving more attention as it provides utility beyond sample size calculation. Meta-analytic-predictive (MAP) priors and robust MAP priors have been proposed for prospectively borrowing historical data on a single endpoint.
arxiv   +1 more source

Melatonin: clinical prospects in immunology

Journal of V. N. Karazin Kharkiv National University: Series Medicine, 2020
Introduction. For a long time, HIV has been associated with a number of inflammatory, infectious and neoplastic skin diseases. In the era of anti-retroviral therapy researchers have found even more about the relationship between skin disease and chronic ...
Tetiana Liadova, Mykola Popov, Diana Dorosh   +2 more
doaj   +1 more source

Hegemonic structure of basic, clinical and patented knowledge on Ebola research: a US army reductionist initiative [PDF]

Journal of Translational Medicine (2015) 13:124, 2016
Background: In this paper, we present an approach to understand how the basic, clinical and patent knowledge on Ebola is organized and intercommunicated and what leading factor could be shaping the evolution of the knowledge translation process for this disease.
arxiv   +1 more source

Prolonged Impairment of Immunological Memory After Anti-CD20 Treatment in Pediatric Idiopathic Nephrotic Syndrome

Frontiers in Immunology, 2019
Anti-CD20 therapy is effective in idiopathic nephrotic syndrome (INS). However, transient or sustained hypogammaglobulinemia predisposing to an increased risk of infectious diseases can follow treatment in some patients. We analyzed the long-term effects
Manuela Colucci, Rita Carsetti, Jessica Serafinelli, Salvatore Rocca, Laura Massella, Antonio Gargiulo, Anna Lo Russo, Claudia Capponi, Nicola Cotugno, Ottavia Porzio, Andrea Onetti Muda, Paolo Palma, Francesco Emma, Francesco Emma, Marina Vivarelli, Marina Vivarelli   +15 more
doaj   +1 more source