Results 21 to 30 of about 493,536 (335)

A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1985-1998, December 2022., 2022
Abstract Objectives Peripheral neuropathy is a relevant dose‐limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity of neurotoxicity often leads to dose reduction or even premature cessation of chemotherapy.
Aina Calls, Abel Torres‐Espin, Marc Tormo, Laura Martínez‐Escardó, Núria Bonet, Ferran Casals, Xavier Navarro, Víctor J. Yuste, Esther Udina, Jordi Bruna   +9 more
wiley   +1 more source

Augmenting adaptive immunity: progress and challenges in the quantitative engineering and analysis of adaptive immune receptor repertoires [PDF]

Mol. Syst. Des. Eng. (2019), 2019
The adaptive immune system is a natural diagnostic and therapeutic. It recognizes threats earlier than clinical symptoms manifest and neutralizes antigen with exquisite specificity. Recognition specificity and broad reactivity is enabled via adaptive B- and T-cell receptors: the immune receptor repertoire.
arxiv   +1 more source

Recognizing early MRI signs (or their absence) is crucial in diagnosing metachromatic leukodystrophy

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1999-2009, December 2022., 2022
Abstract Objectives Metachromatic leukodystrophy (MLD) has characteristic white matter (WM) changes on brain MRI, which often trigger biochemical and genetic confirmation of the diagnosis. In early or pre‐symptomatic disease stages, these typical MRI changes might be absent, hampering early diagnosis.
Daphne H. Schoenmakers, Shanice Beerepoot, Ingeborg Krägeloh‐Mann, Saskia Elgün, Benjamin Bender, Marjo S. van der Knaap, Nicole I. Wolf, Samuel Groeschel   +7 more
wiley   +1 more source

The role of out-of-class work of doctor-interns in improving qualitive academic progress on clinical immunology and allergology under the primary specialization “Internal diseases”.

Medičnì Perspektivi, 2018
The use of independent out-of-class work of interns on the specialty "Internal diseases" in the section of clinical immunology and allergology promoted the improvement of the qualitative success of interns.
G. P. Kuz'mina, V. A. Potabashniy, V. I. Fesenko, O. V. Knjazjeva, V. Je. Azarenko, A. M. Vasylenko, V. E. Khatsko   +6 more
doaj   +1 more source

FUNDAMENTAL STUDIES IN BASIC AND CLINICAL IMMUNOLOGY PERFORMED BY ACADEMICIAN V.I. IOFFE (TO THE 120th ANNIVERSARY OF THE BIRTH OF ACADEMICIAN V.I. IOFFE)

Медицинская иммунология, 2018
In 2018, we celebrate the 120th anniversary of Academician, Professor Vladimir I Ioffe, a leading figure of national immunology. The world-level achievements of V.I.Ioffe in research, his undisputed priority in the most important areas of fundamental ...
P. G. Nazarov, I. S. Freydlin
doaj   +1 more source

Smooth and probabilistic PARAFAC model with auxiliary covariates [PDF]

arXiv, 2021
In immunological and clinical studies, matrix-valued time-series data clustering is increasingly popular. Researchers are interested in finding low-dimensional embedding of subjects based on potentially high-dimensional longitudinal features and investigating relationships between static clinical covariates and the embedding.
arxiv  

Clinical Immunology, the Fifth Edition

Central Asian Journal of Medical Sciences, 2019
No abstract in ...
Enkhsaikhan Lkhagvasuren, Gansukh Choijilsuren, Ariunzaya Bat-Erdene   +2 more
doaj   +1 more source

Deep Historical Borrowing Framework to Prospectively and Simultaneously Synthesize Control Information in Confirmatory Clinical Trials with Multiple Endpoints [PDF]

, 2020
In current clinical trial development, historical information is receiving more attention as it provides utility beyond sample size calculation. Meta-analytic-predictive (MAP) priors and robust MAP priors have been proposed for prospectively borrowing historical data on a single endpoint.
arxiv   +1 more source

Immunological profiles of patients from endemic areas infected with Schistosoma mansoni

Memorias do Instituto Oswaldo Cruz, 1992
Crude extracts of eggs (SEA) adult worms (SWAP) or cercariae (Cerc) have been used to stimulate Peripheral Blood Mononuclear cells (PBMC) and have provided rather distinct profiles of responses in different types of patients. In genenral it is clear that
Giovanni Gazzinelli, Iramaya R. C. Viana, Lilian M. G. Bahia-Oliveira, Alda Maria S. Silveira, Claudia Carvalho Queiroz, Omar dos Santos Carvalho, Cristiano L. Massara, Lucia A. O. Fraga, Daniel G. Colley, Rodrigo Correa Oliveira   +9 more
doaj   +1 more source

Hegemonic structure of basic, clinical and patented knowledge on Ebola research: a US army reductionist initiative [PDF]

Journal of Translational Medicine (2015) 13:124, 2016
Background: In this paper, we present an approach to understand how the basic, clinical and patent knowledge on Ebola is organized and intercommunicated and what leading factor could be shaping the evolution of the knowledge translation process for this disease.
arxiv   +1 more source