Results 31 to 40 of about 493,536 (335)
OncoImmunology, 2018 Purpose: We conducted a phase I vaccine trial to determine safety, toxicity, and immunogenicity of autologous Langerhans-type dendritic cells (LCs), electroporated with murine tyrosinase-related peptide-2 (mTRP2) mRNA in patients with resected AJCC stage
David J. Chung +10 more
doaj +1 more source
Melatonin: clinical prospects in immunology
Journal of V. N. Karazin Kharkiv National University: Series Medicine, 2020 Introduction. For a long time, HIV has been associated with a number of inflammatory, infectious and neoplastic skin diseases. In the era of anti-retroviral therapy researchers have found even more about the relationship between skin disease and chronic ...
Tetiana Liadova +2 more
doaj +1 more source
What is clinical immunology? [PDF]
Journal of Clinical Pathology, 1981 The clinical and laboratory details of 10 patients with predominantly immunological problems were circulated to selected physicians in different forms of hospital practice. In general, these physicians would prefer to select their own immunological tasks and could get these performed in their clinical pathology laboratories or regional immunology ...
openaire +3 more sources
Frontiers in Immunology, 2019 Anti-CD20 therapy is effective in idiopathic nephrotic syndrome (INS). However, transient or sustained hypogammaglobulinemia predisposing to an increased risk of infectious diseases can follow treatment in some patients. We analyzed the long-term effects
Manuela Colucci +15 more
doaj +1 more source
Bayesian Models and Decision Algorithms for Complex Early Phase Clinical Trials [PDF]
Statistical Science 2010, Vol. 25, No. 2, 227-244, 2010 An early phase clinical trial is the first step in evaluating the effects in humans of a potential new anti-disease agent or combination of agents. Usually called "phase I" or "phase I/II" trials, these experiments typically have the nominal scientific goal of determining an acceptable dose, most often based on adverse event probabilities.
arxiv +1 more source
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
The Journal of Clinical Investigation, 2023 BACKGROUND Head and neck squamous cell carcinoma not associated with HPV (HPV-unrelated HNSCC) is associated with a high rate of recurrence and poor survival.METHODS We conducted a clinical trial in 14 patients with newly diagnosed HPV-unrelated HNSCC to
Jason M. Redman +21 more
doaj +1 more source
Frontiers in Immunology, 2020 The majority of medical students and many physicians find basic science immunology confusing and the teaching of immunology to be uninteresting. Physicians undergoing training in a range of disciplines treat patients with immunological disease, including
Mohammed Yousuf Karim +1 more
doaj +1 more source
Increased adaptive immune responses and proper feedback regulation protect against clinical dengue [PDF]
Science Translational Medicine, American Association for the
Advancement of Science, 2017, 9 (405), pp.eaal5088, 2017 Dengue is the most prevalent arthropod-borne viral disease. Clinical symptoms of dengue virus (DENV) infection range from classical mild dengue fever to severe, life-threatening dengue shock syndrome. However, most DENV infections cause few or no symptoms.
arxiv +1 more source