Results 151 to 160 of about 5,430,465 (243)

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

Clinical instructors' perceptions of virtual reality in health professionals' cardiopulmonary resuscitation education. [PDF]

SAGE Open Med, 2018
Wong MAME, Chue S, Jong M, Benny HWK, Zary N.   +4 more
europepmc   +1 more source

Preserving Motor Features by Alternative Re‐Referencing to Remove Heart Artifact on the Stentrode

Advanced Science, EarlyView.
Endovascular brain‐computer interfaces record neural activity from within cerebrovasculature, at the expense of electrocardiogram contamination. Band‐limited independent component analysis separates this heart‐based artifact from task‐relevant neural activity in each frequency band, enabling the reconstruction of cleaner neural recordings without the ...
Ariel K. Feldman, Kriti Kacker, Rahyun Yun, Nikole Chetty, James Bennett, Peter E. Yoo, Raul G. Nogueira, Jennifer L. Collinger, Nicholas L. Opie, Thomas J. Oxley, David F. Putrino, Douglas J. Weber   +11 more
wiley   +1 more source

Correction: Enhancing feedback mechanisms in medical education: insights from clinical instructors in a Taiwanese medical center. [PDF]

BMC Med Educ
Liao CW, Cheng CN, Ho WS, Huang WL, Tsai YJ.   +4 more
europepmc   +1 more source

Therapeutic Gene Editing of APOE4 in Sporadic Alzheimer's Disease via Prime Editor 7

Advanced Science, EarlyView.
Prime Editor 7‐mediated conversion of APOE4 to APOE3 alleviates Alzheimer's disease‐associated pathology in AD mouse models and patient‐derived neurons and improves cognitive performance in vivo, supporting therapeutic genome editing as a promising strategy for APOE4‐associated neurodegeneration.
Yunkyung Kim, Gaeun Lee, Saemin An, Hanseul Park, Hongwon Kim, Jisung Kim, Soi Kang, Sumin Kim, Daeyeol Kwon, Jeonghyun Park, Yerim Hwang, Seonghun Kim, Xiuwen Yuan, Jaehoon Jeong, Hamin Lee, Hui Kwon Kim, Jongpil Kim   +16 more
wiley   +1 more source

Explaining the inhibitory characteristics of clinical instructors in the process of developing clinical competence of nursing students: a qualitative study. [PDF]

J Family Med Prim Care, 2019
Sadeghi A, Oshvandi K, Moradi Y.
europepmc   +1 more source

Programmable Encapsulation Enables On‐Demand Proliferation of Therapeutic Bacteria for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
A programmable encapsulation technology is developed to reduce bacterial immunogenicity and proliferation after systemic administration. The cross‐linked polymer networks around individual bacteria enable immunogenic shielding and permit selective proliferation in tumors, allowing the bacteria to convert tumor‐accumulated ammonia into L‐arginine and ...
Jianhui Yang, Ao Peng, Shuaiqiang Li, Yaning Huang, Jian Yan, Leyuan Wang, Zhihui Zhu, Fei‐Long Liu, Erbao Bian, Yang Liu, Dasheng Tian, Fenghe Li, Qi Liu   +12 more
wiley   +1 more source

Clinical Instructors' Experiences Working with and Assessing Students Who Perform below Expectations in Physical Therapy Clinical Internships. [PDF]

Physiother Can, 2019
So OW, Shaw R, O'Rourke L, Woldegabriel JT, Wade B, Quesnel M, Mori B.   +6 more
europepmc   +1 more source

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

Perception of Medical and Nursing Students Plus Clinical Instructors Towards Objective Structured Clinical Examination: A Case Study of Five Health Training Institutions in Sub-Saharan Africa. [PDF]

Adv Med Educ Pract
Kibuuka R, Mpasa F, Kanyike AM, Ndikom CM, Kaminga AC, Owusu-Sekyere S, Ogah A, Kusi Amponsah A, Kiyimba K, Obakiro SB, Munthali G, Msowoya WK, Kibuule D, Phiri EC, Baluwa M, Phiri T, Katuramu R.   +16 more
europepmc   +1 more source