Results 211 to 220 of about 5,430,465 (243)

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Psychological capital, perceptions of clinical stressors, and bullying experiences among Chinese nursing students during clinical practice: a latent profile and mediation analysis. [PDF]

Front Public Health
Zhao F, Zhang H, Hui K, Zheng H, He Z.
europepmc   +1 more source

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

Designing and Implementing a Simulation-Based Pediatric Trauma Training Program in a Resource-Limited Setting: The PRACTICE Study. [PDF]

Pediatr Rep
Olbrich J, Hönning A, Tavares Latado IL, Laufer A, Schwab J, Haucke E, Jünemann A, Weibrecht U, Bandeira Filho JR, Zappel K, Bakir S.   +10 more
europepmc   +1 more source

Beyond Biomimetics: Pathology‐Informed Engineering Rescues Reconstituted HDL From Inflammatory Dysfunction for Sepsis Immunotherapy

Advanced Science, EarlyView.
A pathology‐informed engineering strategy rescues reconstituted HDL from inflammatory dysfunction in sepsis. By integrating a ceria nanozyme‐celastrol coordination complex, the platform preserves HDL structure and endotoxin handling, sustains hierarchical intracellular delivery, and enhances immunoregulation across pathological models, translating ...
Han Zhou, Lei Zhang, Xingyu Cai, Jiajia Su, Guangyu Dai, Xue Chen, Hanming Wang, Jia Hua, Jianping Liu, Chunmeng Sun, Xiancheng Chen, Erhao Wang, Wenli Zhang   +12 more
wiley   +1 more source

Impact of a Resident-as-Teacher Point-of-Care Ultrasound (POCUS) Curriculum on Learner Confidence: A Prospective Educational Study. [PDF]

Cureus
Izquierdo Pretel G, Uchiyama E, Sadri S, Sharma M.   +3 more
europepmc   +1 more source

Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy

Advanced Science, EarlyView.
A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao, Yuechen Han, Jie Li, Peng Luo, Lin Qi, Zhiwei Xia, Xiaosong Li, Quan Cheng, Chenshen Huang, Wantao Wu, Hao Zhang   +10 more
wiley   +1 more source

Ambient AI Scribes to Create Educational Feedback Notes for Medical Students: Randomized Trial. [PDF]

JMIR Med Educ
Talwalkar JS, Chartash D, Zhang L, Makutonin M, Safranek CW, Sidamon-Eristoff AE, Schwamm LH, Wright DS.   +7 more
europepmc   +1 more source

Relationship between midwifery educators' quality of life and students' clinical training quality. [PDF]

BMC Med Educ
Abbasi E, Abbasifar M, Bazrafkan L.
europepmc   +1 more source

Expectations From Clinical Attachments Among Undergraduate Nursing Programmes. [PDF]

Nurs Open
Degefa AA, Netsere HB, Temesgen WA.
europepmc   +1 more source