Results 11 to 20 of about 13,113,839 (405)

Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19: A Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2020
Importance Remdesivir demonstrated clinical benefit in a placebo-controlled trial in patients with severe coronavirus disease 2019 (COVID-19), but its effect in patients with moderate disease is unknown.
C. Spinner, R. Gottlieb, G. Criner, J. R. Arribas López, A. Cattelan, A. Soriano Viladomiu, O. Ogbuagu, P. Malhotra, K. Mullane, A. Castagna, L. Chai, M. Roestenberg, O. Tsang, E. Bernasconi, Paul Le Turnier, Shan-Chwen Chang, Devi SenGupta, R. Hyland, A. Osinusi, H. Cao, C. Blair, Hongyuan Wang, A. Gaggar, D. Brainard, M. Mcphail, S. Bhagani, M. Ahn, A. Sanyal, G. Huhn, F. Marty   +29 more
semanticscholar   +1 more source

Novel indicator for the spread of new coronavirus disease 2019 and its association with human mobility in Japan

Scientific Reports, 2023
The Japanese government adopted policies to control human mobility in 2020 to prevent the spread of severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019 (COVID-19). The present study examined the impact of human mobility
Yuta Kawakami, Shuko Nojiri, Daisuke Nakamoto, Yoshiki Irie, Satoshi Miyazawa, Manabu Kuroki, Yuji Nishizaki   +6 more
doaj   +1 more source

Efficacy of hydroxychloroquine in patients with COVID-19: results of a randomized clinical trial

medRxiv, 2020
Aims: Studies have indicated that chloroquine (CQ) shows antagonism against COVID-19 in vitro. However, evidence regarding its effects in patients is limited.
Zhaowei Chen, Jijia Hu, Zongwei Zhang, Sha-sha Jiang, Shoumeng Han, D. Yan, Ruhong Zhuang, Ben Hu, Zhan Zhang   +8 more
semanticscholar   +1 more source

A randomized multicenter clinical trial to evaluate the efficacy of melatonin in the prophylaxis of SARS-CoV-2 infection in high-risk contacts (MeCOVID Trial): A structured summary of a study protocol for a randomised controlled trial

Trials, 2020
Objectives Primary objective: to evaluate the efficacy of melatonin as a prophylactic treatment on prevention of symptomatic SARS-CoV-2 infection among healthcare workers at high risk of SARS-CoV-2 exposure. Secondary objectives: To evaluate the efficacy
Irene García García, Miguel Rodriguez-Rubio, Amelia Rodríguez Mariblanca, Lucía Martínez de Soto, Lucía Díaz García, Jaime Monserrat Villatoro, Javier Queiruga Parada, Enrique Seco Meseguer, María J. Rosales, Juan González, José R. Arribas, Antonio J. Carcas, Pedro de la Oliva, Alberto M. Borobia   +13 more
doaj   +1 more source

Comparison of Bayesian and frequentist group-sequential clinical trial designs [PDF]

, 2020
Background: There is a growing interest in the use of Bayesian adaptive designs in late-phase clinical trials. This includes the use of stopping rules based on Bayesian analyses in which the frequentist type I error rate is controlled as in frequentist
Gates, Simon, Ryan, Elizabeth G., Stallard, Nigel, Todd, Sue   +3 more
core   +2 more sources

Favipiravir versus Arbidol for COVID-19: A Randomized Clinical Trial

medRxiv, 2020
Background No clinically proven effective antiviral strategy exists for the epidemic Coronavirus Disease 2019 (COVID-19). Methods We conducted a prospective, randomized, controlled, open-label multicenter trial involving adult patients with COVID-19 ...
Chang Chen, Yi Zhang, Jianying Huang, P. Yin, Zhenshun Cheng, Jianyuan Wu, Song Chen, Yongxi Zhang, Bo Chen, Mengxin Lu, Yongwen Luo, Lingao Ju, Jingyi Zhang, Xinghuan Wang   +13 more
semanticscholar   +1 more source

Prototype of running clinical trials in an untrustworthy environment using blockchain. [PDF]

, 2019
Monitoring and ensuring the integrity of data within the clinical trial process is currently not always feasible with the current research system.
Bhattacharya, Sanchita, Butte, Atul J, Wong, Daniel R   +2 more
core   +3 more sources

Research ethics consultation: an attempt and 5-year experience in a Japanese University Hospital

BMC Research Notes, 2018
Objective Research ethics consultation is an advisory activity that differs from ethics committees, and its role is not yet widely known in Japan. Research ethics consultations were started in 2012 by members of the Clinical Trial Center of Tokushima ...
Hiroaki Yanagawa, Rumi Katashima, Chiho Sato, Kenshi Takechi, Hiroshi Nokihara, Chikako Kane, Masayuki Chuma, Yuki Aoe   +7 more
doaj   +1 more source

Tanshinone ΙΙA-Incubated Mesenchymal Stem Cells Inhibit Lipopolysaccharide-Induced Inflammation of N9 Cells through TREM2 Signaling Pathway

Stem Cells International, 2022
Our previous study found that incubating mesenchymal stem cells (MSC) with tanshinone IIA (TIIA) before transplantation could significantly increase the inhibitory effect of MSC on neuroinflammation.
Nanqu Huang, Juan Huang, Fei Feng, Zhisheng Ba, Yuanyuan Li, Yong Luo   +5 more
doaj   +1 more source

Safety and Tolerability of an Antimalarial Herbal Remedy in Healthy Volunteers: An Open-Label, Single-Arm, Dose-Escalation Study on Maytenus senegalensis in Tanzania

Tropical Medicine and Infectious Disease, 2022
Background: Though Maytenus senegalensis is one of the medicinal plants widely used in traditional medicine to treat infectious and inflammatory diseases in Africa, there is a lack of safety data regarding its use.
Kamaka Kassimu, Florence Milando, Justin Omolo, Abel Mdemu, Gloria Nyaulingo, Hussein Mbarak, Latipha Mohamed, Ramla Rashid, Saumu Ahmed, Mohammed Rashid, Hania Msami, David Damiano, Beatus Simon, Thabit Mbaga, Fatuma Issa, Omar Lweno, Neema Balige, Omary Hassan, Bakari Mwalimu, Ali Hamad, Ally Olotu, Andreas Mårtensson, Francis Machumi, Said Jongo, Billy Ngasala, Salim Abdulla   +25 more
doaj   +1 more source