Results 21 to 30 of about 3,188,395 (233)

Mirroring everyday clinical practice in clinical trial design: a new concept to improve the external validity of randomized double-blind placebo-controlled trials in the pharmacological treatment of major depression [PDF]

, 2012
Background: Randomized, double-blind, placebo-controlled trials constitute the gold standard in clinical research when testing the efficacy of new psychopharmacological interventions in the treatment of major depression.
A Cipriani, A Cipriani, A Hrobjartsson, A Loh, Andrea Pfennig, BR Rutherford, CP Gross, DE Moerman, DL Sackett, EA Largent, Emanuel Severus, F Seemuller, FG Miller, Florian Seemüller, G Parker, GI Papakostas, H Brody, H Brody, Hans-Jürgen Möller, HJ Moller, HJ Moller, HJ Moller, HU Wittchen, HV Krell, J Odgaard-Jensen, L Colloca, L Colloca, M Sinyor, MA Posternak, ME Wechsler, Michael Bauer, Michael Berger, Michael Obermeier, Michael Riedel, R Jones, RE Drake, RW Lam, Sandra Dittmann, SB Patten, SH Kennedy, Sophia Frangou, SR Wisniewski, U Hegerl, U Hegerl   +43 more
core   +3 more sources

The Diabetes Remission Clinical Trial (DiRECT): protocol for a cluster randomised trial [PDF]

, 2016
Background: Despite improving evidence-based practice following clinical guidelines to optimise drug therapy, Type 2 diabetes (T2DM) still exerts a devastating toll from vascular complications and premature death.
Adamson, Ashley, Barnes, Alison, Brosnahan, Naomi, Ford, Ian, Hollingsworth, Kieren G., Kean, Sharon, Lean, Mike E.J., Leslie, Wilma S., Mathers, John C., McCombie, Louise, McIlvenna, Yvonne, Peters, Carl, Rehackova, Lucia, Rodrigues, Angela, Ross, Hazel, Sattar, Naveed, Sniehotta, Falko F., Taylor, Roy, Thom, George, Zhyzhneuskaya, Sviatlana   +19 more
core   +3 more sources

Study protocol: a randomised controlled trial on the clinical effects of levothyroxine treatment for subclinical hypothyroidism in people aged 80 years and over [PDF]

, 2018
Background: Subclinical hypothyroidism is common in older people and its contribution to health and disease needs to be elucidated further. Observational and clinical trial data on the clinical effects of subclinical hypothyroidism in persons aged 80 ...
Blum, M.R., Dekkers, O.M., Den Elzen, W.P.J., Du Puy, R.S., Ford, I., Gussekloo, J., Jukema, J.W., Kean, S., Kearney, P.M., Messow, C.M., Mooijaart, S.P., Peeters, R.P., Poortvliet, R.K.E., Postmus, I., Rodondi, N., Smit, J.W.A., Stott, D.J., van Munster, B.C., Watt, T., Westendorp, R.G.J., Wolffenbuttel, B.H.R.   +20 more
core   +8 more sources

Neuroprotective Properties of Xenon. [PDF]

, 2020
Xenon is a rare noble gas that was introduced into clinical practice more than 70 years ago. Xenon's clinical properties are predicated by its ability to fit into preformed cavities of macromolecules thereby altering their biological functions.
Laitio, Timo, Maze, Mervyn
core  

Implementing the EffTox dose-finding design in the Matchpoint trial [PDF]

, 2017
Background: The Matchpoint trial aims to identify the optimal dose of ponatinib to give with conventional chemotherapy consisting of fludarabine, cytarabine and idarubicin to chronic myeloid leukaemia patients in blastic transformation phase.
Billingham, Lucinda, Brock, Kristian, Copland, Mhairi, Siddique, Shamyla, Sirovica, Mirjana, Yap, Christina   +5 more
core   +4 more sources

Feasibility of a randomized controlled trial of functional strength training for people between six months and five years after stroke: FeSTivaLS trial [PDF]

, 2014
Background: Functional Strength Training (FST) could enhance recovery late after stroke. The aim of this study was to evaluate the feasibility of a subsequent fully powered, randomized controlled trial.
Barton, Garry R., Clark, Allan, Cross, Jane, Mares, Kathryn, McGlashan, Kate, Myint, Phyo K., O'Ddriscoll, Marie-Luce, Poland, Fiona, Pomeroy, Valerie M., Vaughan, Susan, Watson, Martin   +10 more
core   +1 more source

The Master Observational Trial: A New Class of Master Protocol to Advance Precision Medicine. [PDF]

, 2020
This commentary introduces a new clinical trial construct, the Master Observational Trial (MOT), which hybridizes the power of molecularly based master interventional protocols with the breadth of real-world data.
Bergan, Raymond, Dickson, Dane, Johnson, Jennifer, Kurzrock, Razelle, Owens, Rebecca, Subbiah, Vivek   +5 more
core  

A novel universal device "LINGUAL RING Ri.P.A.Ra" for TMDs and cranio-cervico-mandibular pains: preliminary results of a randomized control clinical trial [PDF]

, 2018
The aim of this study was to evaluate functionality and clinical application of a novel immediate device in the treatment of temporomandibular disorders (TMDs).
Di Paolo, C, Papi, P, Polimeni, A, Pompa, G, Rampello, A, Rampello, A   +5 more
core   +1 more source

Potential implications of practice effects in Alzheimer's disease prevention trials. [PDF]

, 2017
IntroductionPractice effects (PEs) present a potential confound in clinical trials with cognitive outcomes. A single-blind placebo run-in design, with repeated cognitive outcome assessments before randomization to treatment, can minimize effects of ...
Ard, M Colin, Bondi, Mark W, Edland, Steven D, Galasko, Douglas R, Jacobs, Diane M, Salmon, David P   +5 more
core   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source