Results 21 to 30 of about 13,113,839 (405)

How to get all trials reported: audit, better data, and individual accountability. [PDF]

, 2015
Reflecting on the new WHO statement on clinical trial registration and reporting, Ben Goldacre proposes simple solutions for ensuring clinical trial results are made publicly ...
Goldacre, Ben
core   +1 more source

Effect of Tocilizumab vs Standard Care on Clinical Worsening in Patients Hospitalized With COVID-19 Pneumonia: A Randomized Clinical Trial.

JAMA Internal Medicine, 2020
Importance The coronavirus disease 2019 (COVID-19) pandemic is threatening billions of people worldwide. Tocilizumab has shown promising results in retrospective studies in patients with COVID-19 pneumonia with a good safety profile.
C. Salvarani, G. Dolci, M. Massari, D. Merlo, S. Cavuto, L. Savoldi, P. Bruzzi, F. Boni, L. Braglia, Caterina Turrà, P. Ballerini, R. Sciascia, L. Zammarchi, O. Para, P. Scotton, W. Inojosa, V. Ravagnani, Nicola Duccio Salerno, P. Sainaghi, A. Brignone, M. Codeluppi, Elisabetta Teopompi, Maurizio Milesi, P. Bertomoro, Norbiato Claudio, M. Salio, M. Falcone, G. Cenderello, Lorenzo Donghi, V. del Bono, P. Colombelli, A. Angheben, A. Passaro, G. Secondo, R. Pascale, I. Piazza, N. Facciolongo, M. Costantini   +37 more
semanticscholar   +1 more source

Clinical Trial Results: A Clinical Trial Bazaar! [PDF]

The Oncologist, 2014
The Oncologist's Clinical Trial Results section welcomes both positive and negative results in an effort to share information, speed discovery, and inform the field. Clinical Trial Results submissions have shown how succinctly the salient features of a submission can be presented, with more in-depth information to be found online.
Susan E. Bates, Antonio Tito Fojo
openaire   +3 more sources

Boosting BCG with recombinant modified vaccinia ankara expressing antigen 85A: Different boosting intervals and implications for efficacy trials [PDF]

, 2007
Objectives. To investigate the safety and immunogenicity of boosting BCG with modified vaccinia Ankara expressing antigen 85A (MVA85A), shortly after BCG vaccination, and to compare this first with the immunogenicity of BCG vaccination alone and second
Adrian V. S. Hill, Ansar A. Pathan, BB Trunz, Clare R. Sander, GA Colditz, H McShane, H McShane, H McShane, Helen A. Fletcher, Helen McShane, HJ Zar, I Cebere, Ian Poulton, J Schneider, James Campbell, JL Flynn, JL Flynn, Kathryn T. Whelan, LA van Pinxteren, LC Rodrigues, LC Rodrigues, Natalie E. R. Beveridge, Nicola C. Alder, P Gorak-Stolinska, RE Weir, SE Dorman, SH Kaufmann, SJ Dunachie, ST Partnership, T Hanke   +29 more
core   +3 more sources

Guidelines for clinical trial protocols for interventions involving artificial intelligence: the SPIRIT-AI extension

Nature Network Boston, 2020
The SPIRIT 2013 statement aims to improve the completeness of clinical trial protocol reporting by providing evidence-based recommendations for the minimum set of items to be addressed.
S. Cruz Rivera, Xiaoxuan Liu, A. Chan, A. Denniston, M. Calvert, Ara Christopher Christopher David Hutan Jonathan J. La Darzi Holmes Yau Moher Ashrafian Deeks Ferrante di, A. Darzi, Christopher Holmes, Christopher Yau, D. Moher, H. Ashrafian, J. J. Deeks, Lavinia Ferrante di Ruffano, Livia Faes, P. Keane, Sebastian J. Vollmer, Aaron Y. Adrian Andre Andrew L. Maria Beatrice Cecilia S Lee Jonas Esteva Beam Panico Lee Haug Kelly Yau Mu, Aaron Y. Lee, Adrian Jonas, Andre Esteva, A. L. Beam, M. Panico, Cecilia S Lee, Charlotte Haug, Christopher J. Kelly, C. Mulrow, Cyrus Espinoza, John Fletcher, Dina Paltoo, Elaine Manna, G. Price, Gary S Collins, Hugh Harvey, James Matcham, João Monteiro, M. Elzarrad, Luke Oakden-Rayner, Melissa McCradden, Richard Savage, R. Golub, Rupa Sarkar, Samuel Rowley   +41 more
semanticscholar   +1 more source

Classification of Subtype of Acute Ischemic Stroke: Definitions for Use in a Multicenter Clinical Trial

Stroke, 1993
Background and Purpose The etiology of ischemic stroke affects prognosis, outcome, and management. Trials of therapies for patients with acute stroke should include measurements of responses as influenced by subtype of ischemic stroke.
Timothy Carter, J. W. Tulloch, Mario Mendez, R. Tarrel, M. Nance, Scott R. Budlie, R. Shapiro, K. Ruggles, P. Gottschalk, Rodney W. Sorenson, D. Jacobson, John G. Schmidt   +11 more
semanticscholar   +1 more source

Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19: A Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2020
Importance Coronavirus disease 2019 (COVID-19) may lead to serious illness as a result of an excessive immune response. Fluvoxamine may prevent clinical deterioration by stimulating the σ-1 receptor, which regulates cytokine production.
E. Lenze, C. Mattar, C. Zorumski, Angela Stevens, J. Schweiger, Ginger E. Nicol, J. P. Miller, Lei Yang, Michael D Yingling, M. Avidan, A. Reiersen   +10 more
semanticscholar   +1 more source

Safety, pharmacokinetics and pharmacodynamics of a novel γ-aminobutyric acid (GABA) receptor potentiator, HSK3486, in Chinese patients with hepatic impairment

Annals of Medicine, 2022
Background The primary objective of this study was to investigate if hepatic impairment alters the safety, pharmacokinetics, and pharmacodynamics of HSK3486.Research design and methods This was a clinical trial of HSK3486 in subjects with normal hepatic ...
Yue Hu, Xiaojiao Li, Jingrui Liu, Hong Chen, Wenbo Zheng, Hong Zhang, Min Wu, Cuiyun Li, Xiaoxue Zhu, Jinfeng Lou, Pangke Yan, Nan Wu, Xiao Liu, Shiping Ma, Xu Wang, Yanhua Ding, Chengluan Xuan   +16 more
doaj   +1 more source

Application of Incident Command Structure to clinical trial management in the academic setting: principles and lessons learned [PDF]

, 2017
Background Clinical trial success depends on appropriate management, but practical guidance to trial organisation and planning is lacking. The Incident Command System (ICS) is the ‘gold standard’ management system developed for managing diverse ...
Michael, Mary J., Reynolds, Penny S., Spiess, Bruce D.   +2 more
core   +2 more sources

Reporting guidelines for clinical trial reports for interventions involving artificial intelligence: the CONSORT-AI extension

Nature Network Boston, 2020
The CONSORT 2010 statement provides minimum guidelines for reporting randomized trials. Its widespread use has been instrumental in ensuring transparency in the evaluation of new interventions.
An-Wen Chan, A. Darzi, Christopher Holmes, Christopher Yau, D. Moher, H. Ashrafian, J. J. Deeks, L. F. D. Ruffano, Livia Faes, Melanie J. Calvert, P. Keane, Samantha Cruz Rivera, Sebastian J. Vollmer, Xiaoxuan Liu, Aaron Y. Lee, Adrian Jonas, Andre Esteva, A. L. Beam, M. Panico, Cecilia S Lee, Charlotte Haug, Christopher J. Kelly, C. Mulrow, Cyrus Espinoza, John Fletcher, Dina Paltoo, Elaine Manna, G. Price, Gary S Collins, Hugh Harvey, James Matcham, João Monteiro, Luke Oakden-Rayner, Melissa McCradden, Richard Savage, R. Golub, Rupa Sarkar, Samuel Rowley   +37 more
semanticscholar   +1 more source