Results 31 to 40 of about 13,113,839 (405)

Managing clinical trials [PDF]

Trials, 2010
Managing clinical trials, of whatever size and complexity, requires efficient trial management. Trials fail because tried and tested systems handed down through apprenticeships have not been documented, evaluated or published to guide new trialists starting out in this important field.
Sara Kenyon, Haleema Shakur, Barbara Farrell   +2 more
openaire   +5 more sources

Reply - Letter to the Editor - Malnutrition: The kiss of grim reaper [PDF]

, 2016
Conducting a large, multicenter, prospective, randomized clinical trial poses a number of challenges. In particular, the successful completion of the trial is based on devising a protocol which could yield to clinically relevant answers yet no becoming
Laviano, Alessandro
core   +1 more source

Disclosure of Clinical Trial Data: Why Exemption 4 of the Freedom of Information Act Should Be Restored [PDF]

, 2005
Clinical trial data generated during the FDA drug approval process can be very valuable. While patients and doctors desperately need this information to make informed choices about medical treatment, drug sponsors strive to keep this resource secret to ...
Boyce, Janene
core   +3 more sources

Designing antifilarial drug trials using clinical trial simulators [PDF]

, 2020
Lymphatic filariasis and onchocerciasis are neglected tropical diseases (NTDs) targeted for elimination by mass (antifilarial) drug administration. These drugs are predominantly active against the microfilarial progeny of adult worms.
A Hoerauf, AC Kuesel, AD Hopkins, AH Tekle, AY Debrah, C Bottomley, C Vegvari, CL King, D Globisch, EK Thomsen, GJ Weil, GJ Weil, GJ Weil, H Kimko, HC Turner, HC Turner, HG Zouré, HP Duerr, J Convit, J Gardon, J Gardon, J Kamgno, JA Filipe, JA Vincent, JD Turner, JE Truscott, JI Hamley, K Awadzi, K Ichimori, K Thorlund, KK Frempong, L Diawara, LE Coffeng, LE Coffeng, M El Setouhy, M Walker, M Walker, MA Irvine, MA Rodríguez-Pérez, Martin Walker, MG Basáñez, MG Basáñez, MG Basáñez, MJ Bockarie, MJ Bockarie, MJ Taylor, MN Katabarwa, MN Katabarwa, MO Traoré, N Dimitri, N Holford, NO Opoku, NTD Modelling Consortium Onchocerciasis Group., P Pallmann, PH Lamberton, R Anderson, R Colebunders, R Lovato, S Belard, S Mand, S Verver, S Wanji, S West, SDS Pion, SR Doyle, TB Higazi, TD Hollingsworth, TS Churcher, U Klarmann-Schulz, World Health Organization., World Health Organization., WS Alley   +71 more
core   +1 more source

Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in acute lung injury to reduce pulmonary dysfunction (HARP-2) trial : study protocol for a randomized controlled trial [PDF]

, 2012
Acute lung injury (ALI) is a common devastating clinical syndrome characterized by life-threatening respiratory failure requiring mechanical ventilation and multiple organ failure.
A Mercat, AM Cheung, C Brun-Buisson, C Rossi, Cecilia M O’Kane, Christine McNally, Daniel F McAuley, DJ Kor, Excellence NIfHaC, F Gao Smith, Gavin D Perkins, GD Rubenfeld, GR Bernard, Grainne Crealey, Irish Critical Care Trials Group, John G Laffey, KF Schulz, LA Curtis, Lynn Murphy, M Shyamsundar, MA Matthay, Mark Cross, Michael Stevenson, MS Herridge, RG Brower, S Harvey, SE Erickson, T Craig, The ARDS Network investigators, The EuroQol Group, TR Craig, TW Felton   +31 more
core   +1 more source

Improving clinical trial outcomes in amyotrophic lateral sclerosis

Nature Reviews Neurology, 2020
Individuals who are diagnosed with amyotrophic lateral sclerosis (ALS) today face the same historically intransigent problem that has existed since the initial description of the disease in the 1860s — a lack of effective therapies.
M. Kiernan, S. Vucic, K. Talbot, C. Mcdermott, O. Hardiman, J. Shefner, A. Al-Chalabi, W. Huynh, M. Cudkowicz, P. Talman, L. H. van den Berg, T. Dharmadasa, P. Wicks, C. Reilly, M. Turner   +14 more
semanticscholar   +1 more source

Stroke treatment academic industry roundtable recommendations for individual data pooling analyses in stroke [PDF]

, 2016
Pooled analysis of individual patient data from stroke trials can deliver more precise estimates of treatment effect, enhance power to examine prespecified subgroups, and facilitate exploration of treatment-modifying influences.
Khatri, Pooja, Lees, Kennedy R., STAIR IX Collaborators,   +2 more
core   +1 more source

A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group.

New England Journal of Medicine, 1997
BACKGROUND It is known that obesity, sodium intake, and alcohol consumption factors influence blood pressure. In this clinical trial, Dietary Approaches to Stop Hypertension, we assessed the effects of dietary patterns on blood pressure.
L. Appel, T. Moore, T. Moore, E. Obarzanek, W. Vollmer, L. Svetkey, F. Sacks, G. Bray, T. Vogt, J. Cutler, M. Windhauser, P. Lin, N. Karanja, D. Simons-Morton, M. McCullough, J. Swain, P. Steele, M. Evans, E. Miller, D. Harsha   +19 more
semanticscholar   +1 more source

Feasibility of simple exercise interventions for men with osteoporosis – A prospective randomized controlled pilot study

Bone Reports, 2021
Background: Aging is associated with progressive loss of musculoskeletal performance. Exercise interventions can improve physical function in the elderly but there is a paucity of comparative assessments in order to understand what specific goals can be ...
Franca Genest, Sarah Lindström, Sophia Scherer, Michael Schneider, Lothar Seefried   +4 more
doaj  

Generating evidence on a risk-based monitoring approach in the academic setting – lessons learned

BMC Medical Research Methodology, 2017
Background In spite of efforts to employ risk-based strategies to increase monitoring efficiency in the academic setting, empirical evidence on their effectiveness remains sparse.
Belinda von Niederhäusern, Annette Orleth, Sabine Schädelin, Nawal Rawi, Martin Velkopolszky, Claudia Becherer, Pascal Benkert, Priya Satalkar, Matthias Briel, Christiane Pauli-Magnus   +9 more
doaj   +1 more source