Results 31 to 40 of about 13,512,505 (380)
Impact of sitagliptin on endometrial mesenchymal stem-like progenitor cells : a randomised, double-blind placebo-controlled feasibility trial [PDF]
, 2020 Background: Recurrent pregnancy loss (RPL) is associated with the loss of endometrial mesenchymal stem-like progenitor cells (eMSC). DPP4 inhibitors may increase homing and engraftment of bone marrow-derived cells to sites of tissue injury.
Brighton, Paul (Paul J.) +13 more
core +1 more source
Decision aids can support cancer clinical trials decisions: Results of a randomized trial [PDF]
, 2016 BACKGROUND. Cancer patients often do not make informed decisions regarding clinical trial participation. This study evaluated whether a web-based decision aid (DA) could support trial decisions compared with our cancer center’s website. METHODS.
Byrne, Margaret M +5 more
core +2 more sources
Reply - Letter to the Editor - Malnutrition: The kiss of grim reaper [PDF]
, 2016 Conducting a large, multicenter, prospective, randomized clinical trial poses a number of challenges. In particular, the successful completion of the trial is based on devising a protocol which could yield to clinically relevant answers yet no becoming
Laviano, Alessandro
core +1 more source
Annals of Medicine, 2022 Background The primary objective of this study was to investigate if hepatic impairment alters the safety, pharmacokinetics, and pharmacodynamics of HSK3486.Research design and methods This was a clinical trial of HSK3486 in subjects with normal hepatic ...
Yue Hu +16 more
doaj +1 more source
Managing clinical trials [PDF]
Trials, 2010 Managing clinical trials, of whatever size and complexity, requires efficient trial management. Trials fail because tried and tested systems handed down through apprenticeships have not been documented, evaluated or published to guide new trialists starting out in this important field.
Sara Kenyon +2 more
openaire +5 more sources
New England Journal of Medicine, 1997 BACKGROUND It is known that obesity, sodium intake, and alcohol consumption factors influence blood pressure. In this clinical trial, Dietary Approaches to Stop Hypertension, we assessed the effects of dietary patterns on blood pressure.
L. Appel +19 more
semanticscholar +1 more source
Improving clinical trial outcomes in amyotrophic lateral sclerosis
Nature Reviews Neurology, 2020 Individuals who are diagnosed with amyotrophic lateral sclerosis (ALS) today face the same historically intransigent problem that has existed since the initial description of the disease in the 1860s — a lack of effective therapies.
M. Kiernan +14 more
semanticscholar +1 more source
Mirroring everyday clinical practice in clinical trial design: a new concept to improve the external validity of randomized double-blind placebo-controlled trials in the pharmacological treatment of major depression [PDF]
, 2012 Background: Randomized, double-blind, placebo-controlled trials constitute the gold standard in clinical research when testing the efficacy of new psychopharmacological interventions in the treatment of major depression.
A Cipriani +43 more
core +3 more sources
Clinical trials on trial [PDF]
European Journal of Hospital Pharmacy, 2012 It has been 3 years since I wrote an editorial on the topic of uncertainty around new cancer treatments (issue 4 of volume 2009). Has this field progressed in 3 years? I think the answer is both yes and no. Yes because we now have a clearer picture of why cancer drugs can sometimes act differently (usually worse) in real life situations than they seem ...
openaire +3 more sources
Bone Reports, 2021 Background: Aging is associated with progressive loss of musculoskeletal performance. Exercise interventions can improve physical function in the elderly but there is a paucity of comparative assessments in order to understand what specific goals can be ...
Franca Genest +4 more
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