Results 41 to 50 of about 13,113,839 (405)
Trial2Vec: Zero-Shot Clinical Trial Document Similarity Search using Self-Supervision [PDF]
arXiv, 2022 Clinical trials are essential for drug development but are extremely expensive and time-consuming to conduct. It is beneficial to study similar historical trials when designing a clinical trial. However, lengthy trial documents and lack of labeled data make trial similarity search difficult.
arxiv
Decision aids can support cancer clinical trials decisions: Results of a randomized trial [PDF]
, 2016 BACKGROUND. Cancer patients often do not make informed decisions regarding clinical trial participation. This study evaluated whether a web-based decision aid (DA) could support trial decisions compared with our cancer center’s website. METHODS.
Byrne, Margaret M +5 more
core +2 more sources
Thoracic Cancer, 2023 Background The clinical characteristics and efficacy of human epidermal growth factor receptor‐2 (HER‐2)‐directed agents against HER2 mutations and HER2 fusions in breast cancer are obscure due to their low frequency. Methods We conducted a retrospective
Yuxin Mu +4 more
doaj +1 more source
SPOT: Sequential Predictive Modeling of Clinical Trial Outcome with Meta-Learning [PDF]
arXiv, 2023 Clinical trials are essential to drug development but time-consuming, costly, and prone to failure. Accurate trial outcome prediction based on historical trial data promises better trial investment decisions and more trial success. Existing trial outcome prediction models were not designed to model the relations among similar trials, capture the ...
arxiv
Clinical trials on trial [PDF]
European Journal of Hospital Pharmacy, 2012 It has been 3 years since I wrote an editorial on the topic of uncertainty around new cancer treatments (issue 4 of volume 2009). Has this field progressed in 3 years? I think the answer is both yes and no. Yes because we now have a clearer picture of why cancer drugs can sometimes act differently (usually worse) in real life situations than they seem ...
openaire +3 more sources
Zhongguo linchuang yanjiu, 2023 Objective To explore the effectiveness of free-examination system for clinical trial subjects in hospital clinical trials. Methods Based on the hospital information system, a free-examination system for clinical trial subjects was designed and ...
ZHANG Rumeng +7 more
doaj +1 more source
Cardiovascular Therapeutics, 2020 Objective. The drug efficacy may differ among different statins, and evidence from head-to-head comparisons is sparse and inconsistent. The study is aimed at comparing the lipid-lowering/increasing effects of 7 different statins in patients with ...
Xiaodan Zhang +10 more
doaj +1 more source
Mirroring everyday clinical practice in clinical trial design: a new concept to improve the external validity of randomized double-blind placebo-controlled trials in the pharmacological treatment of major depression [PDF]
, 2012 Background: Randomized, double-blind, placebo-controlled trials constitute the gold standard in clinical research when testing the efficacy of new psychopharmacological interventions in the treatment of major depression.
A Cipriani +43 more
core +3 more sources
Clinical Trial Information Extraction with BERT [PDF]
arXiv, 2021 Natural language processing (NLP) of clinical trial documents can be useful in new trial design. Here we identify entity types relevant to clinical trial design and propose a framework called CT-BERT for information extraction from clinical trial text.
arxiv
Journal of the American Medical Association (JAMA), 2017 Importance Tumor-treating fields (TTFields) is an antimitotic treatment modality that interferes with glioblastoma cell division and organelle assembly by delivering low-intensity alternating electric fields to the tumor. Objective To investigate whether
R. Stupp +28 more
semanticscholar +1 more source