Results 41 to 50 of about 3,600,128 (335)

Generating evidence on a risk-based monitoring approach in the academic setting – lessons learned

BMC Medical Research Methodology, 2017
Background In spite of efforts to employ risk-based strategies to increase monitoring efficiency in the academic setting, empirical evidence on their effectiveness remains sparse.
Belinda von Niederhäusern, Annette Orleth, Sabine Schädelin, Nawal Rawi, Martin Velkopolszky, Claudia Becherer, Pascal Benkert, Priya Satalkar, Matthias Briel, Christiane Pauli-Magnus   +9 more
doaj   +1 more source

Neuroprotective Properties of Xenon. [PDF]

, 2020
Xenon is a rare noble gas that was introduced into clinical practice more than 70 years ago. Xenon's clinical properties are predicated by its ability to fit into preformed cavities of macromolecules thereby altering their biological functions.
Laitio, Timo, Maze, Mervyn
core  

Design and practice of free-examination of clinical trial subjects based on hospital information system

Zhongguo linchuang yanjiu, 2023
Objective To explore the effectiveness of free-examination system for clinical trial subjects in hospital clinical trials. Methods Based on the hospital information system, a free-examination system for clinical trial subjects was designed and ...
ZHANG Rumeng, CAI Mingmin, CHEN Hong, YANG Yue, CHEN Xi, WANG Guimei, XIE Bo, WANG Huiping   +7 more
doaj   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Digitizing clinical trials [PDF]

npj Digital Medicine, 2020
AbstractClinical trials are a fundamental tool used to evaluate the efficacy and safety of new drugs and medical devices and other health system interventions. The traditional clinical trials system acts as a quality funnel for the development and implementation of new drugs, devices and health system interventions.
Omer T. Inan, Mark J. Pletcher, Katharine Cooper-Arnold, Katharine Cooper-Arnold, Steven R. Steinhubl, S. A. Prindiville, Patrice Desvigne-Nickens, P. Klasnja, Bonnie Spring, Kenneth D. Mandl, D. S. Dizon, R. M. Califf, R. M. Califf, K. L. Preston, Erin Iturriaga, Yves Rosenberg, Harmony R. Reynolds, Benjamin M. Marlin, Mintu P. Turakhia, P. Tenaerts, Harlan M. Krumholz, R. Campo   +21 more
openaire   +5 more sources

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

The effect of food on the pharmacokinetics of WXFL10203614, a potential selective JAK1 inhibitor, in healthy Chinese subjects

Frontiers in Pharmacology, 2022
Objective: This study was performed to investigate the effect of food on the pharmacokinetics (PK) of WXFL10203614 in healthy Chinese subjects.Methods: This was a randomized, open-label, single-dose, two-treatment (fed vs fasted), two-period, two ...
Kai Huang, Yunfei Shi, Nannan Chu, Linling Que, Ying Ding, Zhenzhong Qian, Wei Qin, Xianghong Gu, Jiakun Wang, Zhiwei Zhang, Jianguo Xu, Qing He   +11 more
doaj   +1 more source