Results 71 to 80 of about 1,991,569 (312)

Population Pharmacokinetic/Pharmacodynamic Modeling of Tacrolimus in Renal Transplant Recipients: Impact of CYP3A5 Genotype and Wuzhi Capsule Co-Medication

Drug Design, Development and Therapy
Qiulin Xiang,1 Yi Yang,1 Guoxing Li,1 Song Chen,1,2 Yingying Yang,1,3 Ling Liu,4 Xian Yu1 1Department of Phase I Clinical Trial Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Pharmacy ...
Xiang Q, Yang Y, Li G, Chen S, Yang Y, Liu L, Yu X   +6 more
doaj  

Evaluation of drug-drug interaction between Suraxavir Marboxil (GP681) and itraconazole, and assessment of the impact of gene polymorphism

Frontiers in Pharmacology
IntroductionSuraxavir Marboxil (GP681) is a prodrug metabolized to GP1707D07, which inhibits influenza viral replication by targeting cap-dependent endonuclease through a single oral dose.
Mai Han, Gang Cui, Yan Zhao, Xianbo Zuo, Xiaoxue Wang, Xin Zhang, Na Mi, Jiangli Jin, Chunyan Xiao, Jing Wang, Wei Wu, Yajuan Li, Jintong Li   +12 more
doaj   +1 more source

Comparison of the success of inferior alveolar nerve anesthesia in the mandibular first molars with symptomatic irreversible pulpitis using two anesthetic solutions of prilocaine and mepivacaine: A randomized controlled clinical trial

, 2023
Mahsa Eskandarinezhad, Negin Ghasemi, Parisa Rostami, AmirArdalan Abdollahi   +3 more
openalex   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Study on bioequivalence and influence of obesity-related indicators on pharmacokinetics and pharmacodynamics for insulin degludec in healthy subjects

Scientific Reports
This study aimed to evaluate the bioequivalence between test and reference insulin degludec (IDeg) and the effects of body composition on pharmacokinetics and pharmacodynamics of IDeg in Chinese healthy volunteers.
Rui Su, Lei Wan, Yi Tao, Mingxue Zhu, Junliang Pu, Zhongping Li, Yuan Chen, Chengyong Tang   +7 more
doaj   +1 more source

Clinical Performance of Posterior Inlay‐Retained and Wing‐Retained Monolithic Zirconia Resin‐Bonded Fixed Partial Dentures: Stage One Results of a Randomized Controlled Trial [PDF]

, 2020
Wolfgang Bömicke, Friederike Rathmann, Maximilian Pilz, Justo Lorenzo Bermejo, Moritz Waldecker, Brigitte Ohlmann, Peter Rammelsberg, Andreas Zenthöfer   +7 more
openalex   +1 more source

Evaluation of the efficacy and safety of an innovative flavonoid lotion in patients with haemorrhoid: a randomised clinical trial [PDF]

, 2023
Sara Razdar, Yunes Panahi, Ramtin Mohammadi, Leila Khedmat, Hossein Khedmat   +4 more
openalex   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

A phase I, randomized study to evaluate the safety, tolerability, and pharmacokinetics of mefunidone in healthy subjects

Frontiers in Pharmacology
BackgroundMefunidone is a novel synthetic compound and is better when compared to pirfenidone for the anti-fibrotic treatment of renal fibrosis in end-stage renal disease.
Mai Han, Bishan Huo, Gaoyun Hu, Xin Zhang, Gang Cui, Wei Wu, Na Mi, Shixi Zhang, Jiangli Jin, Xing Lu, Bidong Wu, Chunyan Xiao, Jing Wang, Zheng Bian, Jintong Li   +14 more
doaj   +1 more source

Targeted therapy with a localised abluminal groove, low-dose sirolimus-eluting, biodegradable-polymer coronary stent – five-year results of the TARGET All Comers randomised clinical trial [PDF]

, 2023
Alexandra J. Lansky, Bo Xu, Andreas Baumbach, Henning Kelbæk, Niels van Royen, Ming Zheng, Paul Knaapen, Ton Slagboom, Tom Johnson, Georgios J. Vlachojannis, Karin Arkenbout, Lene Holmvang, Luc Janssens, Salvatore Brugaletta, Christoph Naber, Thomas Schmitz, Richard Anderson, Harald Rittger, Sérgio Berti, Emanuele Barbato, Gábor G. Tóth, Luc Maillard, Christian Valina, Paweł Buszman, Hölger Thiele, Volker Schächinger, William Wijns   +26 more
openalex   +1 more source