Results 11 to 20 of about 3,552,558 (305)

Clinical Trial Results: A Clinical Trial Bazaar! [PDF]

The Oncologist, 2014
The Oncologist's Clinical Trial Results section welcomes both positive and negative results in an effort to share information, speed discovery, and inform the field. Clinical Trial Results submissions have shown how succinctly the salient features of a submission can be presented, with more in-depth information to be found online.
Antonio Tito, Fojo, Susan E, Bates
openaire   +2 more sources

Changing platforms without stopping the train: experiences of data management and data management systems when adapting platform protocols by adding and closing comparisons

Trials, 2019
Background There is limited research and literature on the data management challenges encountered in multi-arm, multi-stage platform and umbrella protocols.
Dominic Hague, Stephen Townsend, Lindsey Masters, Mary Rauchenberger, Nadine Van Looy, Carlos Diaz-Montana, Melissa Gannon, Nicholas James, Tim Maughan, Mahesh K. B. Parmar, Louise Brown, Matthew R. Sydes, for the STAMPEDE and FOCUS4 investigators   +12 more
doaj   +1 more source

Use of vitamins by participants in amyotrophic lateral sclerosis clinical trials.

PLoS ONE, 2020
Patients' vitamin intake is often not documented and is therefore not considered sufficiently in studies of prescribed medication in patients with amyotrophic lateral sclerosis (ALS). We aimed to determine the prevalence of vitamin use by participants in
Tino Prell, Julian Grosskreutz, Pooled Resource Open-Access ALS Clinical Trials Consortium   +2 more
doaj   +1 more source

Treatment estimands in clinical trials of patients hospitalised for COVID-19: ensuring trials ask the right questions

BMC Medicine, 2020
When designing a clinical trial, explicitly defining the treatment estimands of interest (that which is to be estimated) can help to clarify trial objectives and ensure the questions being addressed by the trial are clinically meaningful.
Brennan C. Kahan, Tim P. Morris, Ian R. White, Conor D. Tweed, Suzie Cro, Darren Dahly, Tra My Pham, Hanif Esmail, Abdel Babiker, James R. Carpenter   +9 more
doaj   +1 more source

Accessing routinely collected health data to improve clinical trials: recent experience of access

Trials, 2021
Background Routinely collected electronic health records (EHRs) have the potential to enhance randomised controlled trials (RCTs) by facilitating recruitment and follow-up.
Archie Macnair, Sharon B. Love, Macey L. Murray, Duncan C. Gilbert, Mahesh K. B. Parmar, Tom Denwood, James Carpenter, Matthew R. Sydes, Ruth E. Langley, Fay H. Cafferty   +9 more
doaj   +1 more source

Early and Differential Diagnosis of Dementia and Mild Cognitive Impairment Design and Cohort Baseline Characteristics of the German Dementia Competence Network [PDF]

, 2009
Background: The German Dementia Competence Network (DCN) has established procedures for standardized multicenter acquisition of clinical, biological and imaging data, for centralized data management, and for the evaluation of new treatments.
Frölich, Lutz, Gertz, Hermann-Josef, Hampel, Harald, Henn, Fritz, Heuser, Isabella, Huell, Michael, Jahn, Holger, Jessen, Frank, Kornhuber, Johannes, Luckhaus, Christian, Maier, Wolfgang, Pantel, Johannes, Perneczky, Robert, Peters, Oliver, Rienhoff, Otto, Ruüther, Eckart, Schmidtke, Klaus, Schroeder, Johannes, Seuchter, Susanne A., Weih, Markus, Wiltfang, Jens, Wolf, Stefanie   +21 more
core   +1 more source

Multiple sclerosis, the measurement of disability and access to clinical trial data [PDF]

, 2005
Background: Inferences about long-term effects of therapies in multiple sclerosis (MS) have been based on surrogate markers studied in short-term trials.
Daumer, Martin, Ebers, G. C., Heigenhauser, L., Lederer, C., Noseworthy, J. H.   +4 more
core   +2 more sources

This is a platform alteration: a trial management perspective on the operational aspects of adaptive and platform and umbrella protocols

Trials, 2019
Background There are limited research and literature on the trial management challenges encountered in running adaptive platform trials. This trial design allows both (1) the seamless addition of new research comparisons when compelling clinical and ...
Francesca Schiavone, Riya Bathia, Krishna Letchemanan, Lindsey Masters, Claire Amos, Anna Bara, Louise Brown, Clare Gilson, Cheryl Pugh, Nafisah Atako, Fleur Hudson, Mahesh Parmar, Ruth Langley, Richard S. Kaplan, Chris Parker, Gert Attard, Noel W. Clarke, Silke Gillessen, Nicholas D. James, Tim Maughan, Matthew R. Sydes, On behalf of past and present members of the STAMPEDE and FOCUS4 Trial Management Group   +21 more
doaj   +1 more source

Overlap between adverse events (AEs) and serious adverse events (SAEs): a case study of a phase III cancer clinical trial

Trials, 2020
Background Safety data is required to be collected in all clinical trials and can be separated into two types of data, adverse events and serious adverse events.
Elizabeth C. James, David Dunn, Adrian D. Cook, Andrew R. Clamp, Matthew R. Sydes   +4 more
doaj   +1 more source

Implementing monitoring triggers and matching of triggered and control sites in the TEMPER study: a description and evaluation of a triggered monitoring management system

Trials, 2019
Background Triggered monitoring in clinical trials is a risk-based monitoring approach where triggers (centrally monitored, predefined key risk and performance indicators) drive the extent, timing, and frequency of monitoring visits.
Carlos Diaz-Montana, William J. Cragg, Rahela Choudhury, Nicola Joffe, Matthew R. Sydes, Sally P. Stenning   +5 more
doaj   +1 more source