Results 41 to 50 of about 7,990,092 (312)

Exploring and adjusting for potential learning effects in ROLARR: a randomised controlled trial comparing robotic-assisted vs. standard laparoscopic surgery for rectal cancer resection

open access: yesTrials, 2018
Background Commonly in surgical randomised controlled trials (RCT) the experimental treatment is a relatively new technique which the surgeons may still be learning, while the control is a well-established standard.
Neil Corrigan   +5 more
doaj   +1 more source

Clinical Trials and the Role of the Oncology Clinical Trials Nurse [PDF]

open access: yesNursing Clinics of North America, 2017
Clinical trials are paramount to improving human health. New trial designs and informed consent issues are emerging as a result of genomic profiling and the development of molecularly targeted agents. Many groups and individuals are responsible for ensuring the protection of research participants and the quality of the data produced. The specialty role
Elizabeth A, Ness, Cheryl, Royce
openaire   +2 more sources

Research Report 2011 [PDF]

open access: yes, 2012
The NHMRC Clinical Trials Centre (CTC) at the University of Sydney runs large multicentre investigator-initiated clinical trials, takes part in trials of national and international collaborative trial groups and contributes expertise to trials run by ...
NHMRC Clinical Trials Centre
core  

Opportunities and Challenges for Decentralized Clinical Trials: European Regulators' Perspective [PDF]

open access: yes, 2022
Decentralized clinical trials (DCTs) have the potential to improve accessibility, diversity, and retention in clinical trials by moving trial activities to participants' homes and local surroundings. In this study, we conducted semi-structured interviews
Trials@Home Consortium
core  

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin   +17 more
wiley   +1 more source

Research Report 2010 [PDF]

open access: yes, 2011
The NHMRC Clinical Trials Centre at the University of Sydney conducts large multicentre investigator-initiated clinical trials, takes part in trials of national and international collaborative trial groups and contributes expertise to trials run by ...
NHMRC Clinical Trials Centre
core  

Therapeutic Apheresis in Nigeria: A Multi‐Center Summary of Abstracts From the Inaugural Nigerian Society for Apheresis Scientific Meeting

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye   +33 more
wiley   +1 more source

Research Report 2004–2005 [PDF]

open access: yes, 2006
The National Health and Medical Research Council Clinical Trials Centre has the purpose of improving outcomes in health through clinical trials research.
NHMRC Clinical Trials Centre
core  

A statistical framework for quantifying clinical equipoise for individual cases during randomized controlled surgical trials [PDF]

open access: yes, 2011
Background Randomised controlled trials are being increasingly used to evaluate new surgical interventions. There are a number of problematic methodological issues specific to surgical trials, the most important being identifying whether patients are ...
Girling, Alan   +15 more
core   +2 more sources

Experience With Performing Rheocarna Therapy via the Single‐Needle Method for Treatment of Chronic Limb‐Threatening Ischemia

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This study investigated the safety and efficacy of single‐needle Rheocarna therapy for chronic limb‐threatening ischemia (CLTI) with wounds. Methods Six patients with CLTI involving ulcers unresponsive to revascularization underwent single‐needle Rheocarna treatment.
Yasutaka Yamauchi   +9 more
wiley   +1 more source

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