Results 41 to 50 of about 3,552,558 (305)

Survival Outcomes and Complications Among Canadian Children With Retinoblastoma: A Population‐Based Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Retinoblastoma (RB) is the most common pediatric ocular cancer, yet population‐based data on survival and risk factors remain limited. This study aimed to describe survival in a large national RB cohort and identify predictors of death and complications.
Samuel Sassine, Ofélie Trudeau‐Ferrin, Caroline Laverdière, Patrick Hamel, Rosanne Superstein, Bénédicte Koukoui, Carole Provost, Paul C. Nathan, Vijay Ramaswamy, Furqan Shaikh, Brenda Gallie, Ashwin Mallipatna, Stephanie Kletke, Helen Dimaras, Hallie Coltin   +14 more
wiley   +1 more source

Approaches and experiences implementing remote, electronic consent at the Leeds Clinical Trials Research Unit

Trials
Background Use of electronic methods to support informed consent (‘eConsent’) is increasingly popular in clinical research. This commentary reports the approach taken to implement electronic consent methods and subsequent experiences from a range of ...
William J Cragg, Chris Taylor, Lauren Moreau, Howard Collier, Rachael Gilberts, Niamh McKigney, Joanna Dennett, Sandra Graca, Ian Wheeler, Liam Bishop, Adam Barrett, Suzanne Hartley, John P Greenwood, Peter P Swoboda, Amanda J Farrin   +14 more
doaj   +1 more source

Outcomes in Trials for Management of Caries Lesions (OuTMaC):protocol [PDF]

, 2015
Background Clinical trials on caries lesion management use an abundance of outcomes, hampering comparison or combination of different study results and their efficient translation into clinical practice.
D Ricketts, F Schwendicke, Falk Schwendicke, IP Sinha, MG Rasines Alcaraz, Nicola Innes, P Petersen, P Williamson, Thomas Lamont, V Smail-Faugeron, W Marcenes   +10 more
core   +6 more sources

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Exploring and adjusting for potential learning effects in ROLARR: a randomised controlled trial comparing robotic-assisted vs. standard laparoscopic surgery for rectal cancer resection

Trials, 2018
Background Commonly in surgical randomised controlled trials (RCT) the experimental treatment is a relatively new technique which the surgeons may still be learning, while the control is a well-established standard.
Neil Corrigan, Helen Marshall, Julie Croft, Joanne Copeland, David Jayne, Julia Brown   +5 more
doaj   +1 more source

Distributed Queries for Quality Control Checks in Clinical Trials [PDF]

, 2011
Operational Quality Control (QC) checks are standard practice in clinical trials and ensure ongoing compliance with the study protocol, standard operating procedures (SOPs) and Good Clinical Practice (GCP).
Brinkley, James F, Detwiler, Landon T, Franklin, Joshua D, Nichols, Nolan   +3 more
core   +1 more source

Multi-center clinical trials: Randomization and ancillary statistics

, 2008
The purpose of this paper is to investigate and develop methods for analysis of multi-center randomized clinical trials which only rely on the randomization process as a basis of inference.
Zelen, Marvin, Zheng, Lu
core   +1 more source

The Master Observational Trial: A New Class of Master Protocol to Advance Precision Medicine. [PDF]

, 2020
This commentary introduces a new clinical trial construct, the Master Observational Trial (MOT), which hybridizes the power of molecularly based master interventional protocols with the breadth of real-world data.
Bergan, Raymond, Dickson, Dane, Johnson, Jennifer, Kurzrock, Razelle, Owens, Rebecca, Subbiah, Vivek   +5 more
core  

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

EO9 (Apaziquone): from the clinic to the laboratory and back again [PDF]

, 2013
EO9 (Apaziquone) is a bioreductive drug that has a chequered history. It underwent clinical trial but failed to show activity in phase II clinical trials when administered i.v.
Aamdal, Adams, Bailey, Bailey, Basu, Bibby, Bibby, Burd, Butler, Cadenas, Ceelen, Choudry, Collard, Connors, Cowan, Cummings, Denny, Dirix, Ernster, Fitzsimmons, Gofrit, Hall, Hargreaves, Hay, Hay, Hay, Hendricksen, Hendricksen, Hendriks, Jain, Loadman, Lu, Maliepaard, Masters, Masters, McKeown, McLeod, Milbank, Minchinton, Oostveen, Pavlidis, Phillips, Phillips, Phillips, Phillips, Phillips, Phillips, Pizao, Plumb, Plumb, Plumb, Puri, Rademakers, Robertson, Robertson, Roed, Schellens, Segura-Aguilar, Siegel, Siegel, Smitskamp-Wilms, Stratford, Sylvester, Tercel, van der Heijden, van der Schoot, van der Schoot, van der Schoot, Vaupel, Vaupel, Walton, Walton, Workman, Workman, Workman, Zappa   +75 more
core   +1 more source