Results 31 to 40 of about 7,990,092 (312)

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

Drug re-purposing to improve outcomes in the management of prostate cancer – aims, outcome measures and design of current phase III trials

BMC Pharmacology and Toxicology
Prostate cancer remains a major cause of cancer morbidity and mortality and is rising in incidence across the world. Although a succession of randomised controlled trials have improved outcomes across all stages of disease, there remain significant ...
Duncan C. Gilbert, Ruth E. Langley, Dami Ayadi, Mannab Berhanu, Lakshmi Kowdley Hemanth, Seunghee Kwon, Hossameldin Abdallah, Angela Meade, Noel Clarke, Silke Gillessen, Nicholas James, Gauthier Bouche, Mahesh Parmar, Matthew Nankivell, Laura Murphy   +14 more
doaj   +1 more source

GA101 (obinutuzumab) monocLonal Antibody as Consolidation Therapy In CLL (GALACTIC) trial: study protocol for a phase II/III randomised controlled trial

Trials, 2017
Background Chronic lymphocytic leukaemia (CLL) is the most common adult leukaemia. Achieving minimal residual disease (MRD) negativity in CLL is an independent predictor of survival even with a variety of different treatment approaches and regardless of ...
Jamie B. Oughton, Laura Collett, Dena R. Howard, Anna Hockaday, Talha Munir, Kathryn McMahon, Lucy McParland, Claire Dimbleby, David Phillips, Andy C. Rawstron, Peter Hillmen   +10 more
doaj   +1 more source

Paying clinicians to join clinical trials : a review of guidelines and interview study of trialists [PDF]

, 2009
Background: The motivations of clinicians to participate in clinical trials have been little studied. This project explored the potential role of payment for participation in publicly funded clinical trials in the UK.
Raftery James, Kerr Christine, Hawker, Sheila, Powell John, Powell, John, Hawker Sheila, Raftery, James, Kerr, Christine   +7 more
core   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

Clinical Trials Unit Newsletter - Issue 02 [PDF]

What\u27s inside this issue: The Clinical Trials Summit of Pakistan 2025 Biosimilar trials at CTU! Completion of the Panbio Self-Test Enrolment Coming Together for Better Cancer Care Informative Snippets Clinical Trials Unit celebrates Clinical Trials ...
Clinical Trials Unit (CTU),
core   +1 more source

Sharing data from clinical trials: the rationale for a controlled access approach. [PDF]

, 2015
The move towards increased transparency around clinical trials is welcome. Much focus has been on under-reporting of trials and access to individual patient data to allow independent verification of findings.
Parmar, MK, Meredith, SK, Mary Rauchenberger, Matthew R Sydes, Annabelle South, Anthony L Johnson, Mahesh KB Parmar, Sydes, MR, Johnson, AL, South, A, Rauchenberger, M, Sarah K Meredith   +11 more
core   +2 more sources

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Approaches and experiences implementing remote, electronic consent at the Leeds Clinical Trials Research Unit

Trials
Background Use of electronic methods to support informed consent (‘eConsent’) is increasingly popular in clinical research. This commentary reports the approach taken to implement electronic consent methods and subsequent experiences from a range of ...
William J Cragg, Chris Taylor, Lauren Moreau, Howard Collier, Rachael Gilberts, Niamh McKigney, Joanna Dennett, Sandra Graca, Ian Wheeler, Liam Bishop, Adam Barrett, Suzanne Hartley, John P Greenwood, Peter P Swoboda, Amanda J Farrin   +14 more
doaj   +1 more source