Results 21 to 30 of about 14,066,519 (402)
BMC Medicine, 2020 When designing a clinical trial, explicitly defining the treatment estimands of interest (that which is to be estimated) can help to clarify trial objectives and ensure the questions being addressed by the trial are clinically meaningful.
Brennan C. Kahan +9 more
doaj +1 more source
Accessing routinely collected health data to improve clinical trials: recent experience of access
Trials, 2021 Background Routinely collected electronic health records (EHRs) have the potential to enhance randomised controlled trials (RCTs) by facilitating recruitment and follow-up.
Archie Macnair +9 more
doaj +1 more source
Impact of the European Clinical Trials Directive on prospective academic clinical trials associated with BMT [PDF]
, 2011 The European Clinical Trials Directive (EU 2001; 2001/20/EC) was introduced to improve the efficiency of commercial and academic clinical trials. Concerns have been raised by interested organizations and institutions regarding the potential for negative ...
A Hartmann +14 more
core +3 more sources
PLoS Medicine, 2014 BackgroundA malaria vaccine could be an important addition to current control strategies. We report the safety and vaccine efficacy (VE) of the RTS,S/AS01 vaccine during 18 mo following vaccination at 11 African sites with varying malaria transmission ...
RTS,S Clinical Trials Partnership
doaj +1 more source
SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials
British medical journal, 2013 High quality protocols facilitate proper conduct, reporting, and external review of clinical trials. However, the completeness of trial protocols is often inadequate.
A. Chan +12 more
semanticscholar +1 more source
Clinical Trial Results: A Clinical Trial Bazaar! [PDF]
The Oncologist, 2014 The Oncologist's Clinical Trial Results section welcomes both positive and negative results in an effort to share information, speed discovery, and inform the field. Clinical Trial Results submissions have shown how succinctly the salient features of a submission can be presented, with more in-depth information to be found online.
Antonio Tito, Fojo, Susan E, Bates
openaire +2 more sources
Cancer Clinical Trials Optimization and Pharmacogenomics [PDF]
, 2012 A critical overview of recent clinical trials in cancer is presented focused on signaling pathways blockers or inhibitors with a view to developing successful clinical trials employing personalized cancer therapies.
I. C. Baianu
core +2 more sources
What to do about poor clinical performance in clinical trials [PDF]
, 2002 The performance of individual clinicians is being monitored as never before. Su Mason and colleagues discuss the implications of this for clinical trials and recommend what should happen if during a trial the performance of one clinician or one centre is
Lilford, R., Mason, S., Nicholl, J.
core +2 more sources
Informed consent and placebo effects: a content analysis of information leaflets to identify what clinical trial participants are told about placebos [PDF]
, 2012 BackgroundPlacebo groups are used in randomised clinical trials (RCTs) to control for placebo effects, which can be large. Participants in trials can misunderstand written information particularly regarding technical aspects of trial design such as ...
Adams, Alison E.M. +3 more
core +5 more sources
Trials, 2019 Background Triggered monitoring in clinical trials is a risk-based monitoring approach where triggers (centrally monitored, predefined key risk and performance indicators) drive the extent, timing, and frequency of monitoring visits.
Carlos Diaz-Montana +5 more
doaj +1 more source