Results 51 to 60 of about 3,635,661 (309)

PARIST study protocol: a phase I/II randomised, controlled clinical trial to assess the feasibility, safety and effectiveness of paracetamol in resolving acute kidney injury in children with severe malaria

BMJ Open, 2023
Background Acute kidney injury (AKI) has in the past been considered a rare complication of malaria in children living in high-transmission settings. More recently, however, a growing number of paediatric case series of AKI in severe malaria studies in ...
Peter Olupot-Olupot, George Paasi, Carolyne Ndila, Charles Benard Okalebo, Paul Ongodia, Cate Namayanja, Egiru Emma Isaiah Eregu, Grace Abongo, Moses Olupot, Denis Amorut, Rita Muhindo, William Okiror   +11 more
doaj   +1 more source

Performance of mesenchymal cell-scaffold constructs in human oral reconstructive surgery: a systematic review [PDF]

, 2016
Background: Different sources of cultured cells combined with different scaffolds (allogenic, xenogeneic, alloplastic or composite materials) have been tested extensively in vitro and in preclinical animal studies, but there have been only a few ...
ANNIBALI, Susanna, Cristalli, Maria Paola, LA MONACA, Gerardo, MARINI, ROBERTA, Patini, Romeo, PRANNO, NICOLA   +5 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Measuring commissioners’ willingness-to-pay for community based childhood obesity prevention programmes using a discrete choice experiment

BMC Public Health, 2020
Background In the UK, rates of childhood obesity remain high. Community based programmes for child obesity prevention are available to be commissioned by local authorities.
Edward J. D. Webb, Elizabeth Stamp, Michelle Collinson, Amanda J. Farrin, June Stevens, Wendy Burton, Harry Rutter, Holly Schofield, Maria Bryant   +8 more
doaj   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Early warnings and repayment plans: novel trial management methods for monitoring and managing data return rates in a multi-centre phase III randomised controlled trial with paper Case Report Forms

Trials, 2019
Background Monitoring and managing data returns in multi-centre randomised controlled trials is an important aspect of trial management. Maintaining consistently high data return rates has various benefits for trials, including enhancing oversight ...
William J. Cragg, Fay Cafferty, Carlos Diaz-Montana, Elizabeth C. James, Johnathan Joffe, Monica Mascarenhas, Victoria Yorke-Edwards   +6 more
doaj   +1 more source

Outcomes in Trials for Management of Caries Lesions (OuTMaC):protocol [PDF]

, 2015
Background Clinical trials on caries lesion management use an abundance of outcomes, hampering comparison or combination of different study results and their efficient translation into clinical practice.
D Ricketts, F Schwendicke, Falk Schwendicke, IP Sinha, MG Rasines Alcaraz, Nicola Innes, P Petersen, P Williamson, Thomas Lamont, V Smail-Faugeron, W Marcenes   +10 more
core   +6 more sources

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Developing a knowledge transfer and exchange strategy for a clinical trials unit

Trials
Need for a strategic approach to knowledge transfer and exchange Late-phase clinical trials and systematic reviews find results that have the potential to improve health outcomes for people.
Annabelle South, Berta Terré Torras, Hannah Rush, Anna Goodman, Sharon Love   +4 more
doaj   +1 more source

The MUK eight protocol: a randomised phase II trial of cyclophosphamide and dexamethasone in combination with ixazomib, in relapsed or refractory multiple myeloma (RRMM) patients who have relapsed after treatment with thalidomide, lenalidomide and a proteasome inhibitor

Trials, 2020
Background Multiple myeloma is a plasma cell tumour with approximately 5500 new cases in the UK each year. Ixazomib is a next generation inhibitor of the 20S proteasome and is thought to be an effective treatment for those who have relapsed from ...
Samantha Hinsley, Katrina Walker, Debbie Sherratt, Lucy Bailey, Sadie Reed, Louise Flanagan, Sophie McKee, Fiona Brudenell Straw, Bryony Dawkins, David Meads, Holger W. Auner, Martin F. Kaiser, Mark Cook, Sarah Brown, Gordon Cook, on behalf of the Myeloma UK Clinical Trials Network   +15 more
doaj   +1 more source