Results 51 to 60 of about 14,066,519 (402)
Advancing Pediatric Antibacterial Drug Development: A Critical Need to Reinvent our Approach. [PDF]
, 2019 The Clinical Trials Transformation Initiative convened with several groups in the pediatric antibacterial drug development community with the goal of identifying challenges and recommending ways to improve current practice.
Bradley, John +3 more
core +1 more source
Representation of South Asian people in randomised clinical trials: analysis of trials' data [PDF]
, 2003 Excluding patients of ethnic minority groups from clinical trials is unethical, introduces substantial bias, and means that findings are based on unrepresentative populations.
Atkin, K. +4 more
core +3 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Pediatric patients with extracranial solid tumors (ST) receiving chemotherapy are at an increased risk for Pneumocystis jirovecii pneumonia (PJP). However, evidence guiding prophylaxis practices in this population is limited. A PJP‐related fatality at our institution highlighted inconsistent prescribing approaches and concerns about
Kriti Kumar +8 more
wiley +1 more source
Active Clinical Trials for Personalized Medicine
, 2015 Individualized treatment rules (ITRs) tailor treatments according to individual patient characteristics. They can significantly improve patient care and are thus becoming increasingly popular.
Cheng, Guang +2 more
core +2 more sources
The Virtual International Stroke Trials Archive [PDF]
, 2007 BACKGROUND AND PURPOSE: Stroke has global importance and it causes an increasing amount of human suffering and economic burden, but its management is far from optimal. The unsuccessful outcome of several research programs highlights the need for reliable
Ali, M. +19 more
core +3 more sources
Clinical trials of new drugs for Alzheimer disease
Journal of Biomedical Sciences, 2020 Alzheimer disease (AD) accounts for 60–70% of dementia cases. Given the seriousness of the disease and continual increase in patient numbers, developing effective therapies to treat AD has become urgent.
Li‐Kai Huang +2 more
semanticscholar +1 more source
Sickle Cell Disease Is an Inherent Risk for Asthma in a Sibling Comparison Study
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction Sickle cell disease (SCD) and asthma share a complex relationship. Although estimates vary, asthma prevalence in children with SCD is believed to be comparable to or higher than the general population. Determining whether SCD confers an increased risk for asthma remains challenging due to overlapping symptoms and the ...
Suhei C. Zuleta De Bernardis +9 more
wiley +1 more source
Trials, 2017 Background Chronic lymphocytic leukaemia (CLL) is the most common adult leukaemia. Achieving minimal residual disease (MRD) negativity in CLL is an independent predictor of survival even with a variety of different treatment approaches and regardless of ...
Jamie B. Oughton +10 more
doaj +1 more source
Estimands in published protocols of randomised trials: urgent improvement needed
Trials, 2021 Background An estimand is a precise description of the treatment effect to be estimated from a trial (the question) and is distinct from the methods of statistical analysis (how the question is to be answered).
Brennan C. Kahan +4 more
doaj +1 more source