SPOT: Sequential Predictive Modeling of Clinical Trial Outcome with Meta-Learning [PDF]
arXiv, 2023 Clinical trials are essential to drug development but time-consuming, costly, and prone to failure. Accurate trial outcome prediction based on historical trial data promises better trial investment decisions and more trial success. Existing trial outcome prediction models were not designed to model the relations among similar trials, capture the ...
Sun, Jimeng, Wang, Zifeng, Xiao, Cao
arxiv +5 more sources
Hepatitis C. Development of new drugs and clinical trials: Promises and pitfalls. Summary of an AASLD hepatitis single topic conference, Chicago, IL, February 27-March 1, 2003 [PDF]
Hepatology, 2004 Chronic hepatitis C virus (HCV) infection affects a large number of patients worldwide. While our current therapies (Table 1) are effective in approximately 50% of patients, therapy is costly, prolonged, and associated with significant side effects, and ...
Jean‐Michel Pawlotsky +1 more
openalex +2 more sources
Multi-armed Bandit Models for the Optimal Design of Clinical Trials: Benefits and Challenges [PDF]
Statistical Science 2015, Vol. 30, No. 2, 199-215, 2015 Multi-armed bandit problems (MABPs) are a special type of optimal control problem well suited to model resource allocation under uncertainty in a wide variety of contexts. Since the first publication of the optimal solution of the classic MABP by a dynamic index rule, the bandit literature quickly diversified and emerged as an active research topic ...
S. Villar, J. Bowden, J. Wason
arxiv +3 more sources
Community and topic modeling for infectious disease clinical trial recommendation [PDF]
Network Modeling Analysis in Health Informatics and Bioinformatics, 2021 Clinical trials are crucial for the advancement of treatment and knowledge within the medical community. Although the ClinicalTrials.gov initiative has resulted in a rich source of information for clinical trial research, only a handful of analytic studies have been carried out to understand this valuable data source. Analysis of this database provides
Magdalyn E. Elkin, Xingquan Zhu
openalex +3 more sources
Centre selection for clinical trials and the generalisability of results: a mixed methods study. [PDF]
PLoS ONE, 2013 BACKGROUND: The rationale for centre selection in randomised controlled trials (RCTs) is often unclear but may have important implications for the generalisability of trial results.
A Britton +38 more
core +4 more sources
Methodological and statistical topics in randomized controlled clinical trials [PDF]
Arquivos Brasileiros de Cardiologia, 1999 Cláudia Caminha Escosteguy
+10 more sources
What is an “ongoing” clinical trial? An analysis of different sources revealed heterogeneous definitions of when a clinical trial starts and ends: a meta-research study [PDF]
São Paulo Medical Journal, 2023 BACKGROUND: Although the concept of an “ongoing study” seems self-explanatory, it is difficult to determine whether a trial is underway. OBJECTIVE: To analyze the definitions of “ongoing clinical trial” across different clinical trial registries ...
Rafael Leite Pacheco +2 more
doaj +1 more source
Clinical Trials in Portugal: How Can we Improve?
Acta Médica Portuguesa, 2021 N/a.
Marta Carvalho +9 more
doaj +1 more source
Reassessment of Historical Clinical Trials Supports the Effectiveness of Phage Therapy
Clinical Microbiology Reviews, 2022 Phage therapy has become a hot topic in medical research due to the increasing prevalence of antibiotic-resistant bacteria strains. In the treatment of bacterial infections, bacteriophages have several advantages over antibiotics, including strain ...
L. Marongiu +4 more
semanticscholar +1 more source