Results 111 to 120 of about 635,069 (409)

NEW ADVANCES IN BETA-BLOCKER THERAPY IN HEART FAILURE

Frontiers in Physiology, 2013
The use of -blockers (BB) in heart failure (HF) has been considered a contradiction for many years. Considering HF simply as a state of inadequate systolic function, BB were contraindicated because of their negative effects on myocardial contractility ...
Vincenzo eBarrese, Maurizio eTaglialatela, Maurizio eTaglialatela   +2 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Is it possible to estimate the minimal clinically important treatment effect needed to change practice in preterm birth prevention? Results of an obstetrician survey used to support the design of a trial

BMC Medical Research Methodology, 2012
Background Sample sizes for obstetrical trials are often based on the opinion of investigators about clinically important effect size. We surveyed Canadian obstetricians to investigate clinically important effect sizes required before introducing new ...
Ross Sue, Milne Jill, Dwinnell Shannon, Tang Selphee, Wood Stephen   +4 more
doaj   +1 more source

Using mobile technology to engage sexual and gender minorities in clinical research. [PDF]

, 2019
IntroductionHistorical and current stigmatizing and discriminatory experiences drive sexual and gender minority (SGM) people away from health care and clinical research.
Bibbins-Domingo, Kirsten, Capriotti, Matthew R, Flentje, Annesa, Frazier, Jeffrey, Lunn, Mitchell R, Obedin-Maliver, Juno, Pletcher, Mark J, Sooksaman, Chollada, Triano, Antony J   +8 more
core   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Vitamin D for the Treatment of Epilepsy: Basic Mechanisms, Animal Models and Clinical Trials

Frontiers in Neurology, 2016
There is increasing evidence supporting dietary and alternative therapies for epilepsy, including the ketogenic diet, modified Atkins diet, and omega-3 fatty acids.
Kevin Pendo, Christopher Michael DeGiorgio, MD   +1 more
doaj   +1 more source

Olive Leaf Extract as a New Topical Management for Oral Mucositis Following Chemotherapy: A Microbiological Examination, Experimental Animal Study and Clinical Trial [PDF]

Pharmaceutica Analytica Acta, 2013
Oral mucositis is a common complication of intensive cancer chemotherapy and radiotherapy. Olive leaf extract was investigated through microbiological, experimental animal studies and clinical trial. The results were compared with the action of benzydamine HCl as positive control and normal saline as negative control.
openaire   +1 more source

Does the engagement of clinicians and organisations in research improve healthcare performance: a three-stage review [PDF]

, 2015
Objective: There is a widely held assumption that engagement by clinicians and healthcare organisations in research improves healthcare performance at various levels, but little direct empirical evidence has previously been collated.
Abraham, Bennett, Bernard, Boaz, Bowen, Carpenter, Chaney, Clarke, Cohen, Cooke, Darbyshire, Denis, Department of Health, Department of Health, Dixon-Woods, Du Bois, Ducharme, Francis, Goldberg, Greenhalgh, Hall, Hanney, Jagosh, Kizer, Kizer, Knudsen, Kuehlein, Laliberte, Lewin, Liberati, Lomas, Majumdar, Minasian, NHS Confederation, Oxman, Pincus, Pons, Puoane, Rich, Rochon, Rochon, Rogers, Selby, Smee, Soper, Spurgeon, Teal, Walshe, Whicher, Zerhouni   +49 more
core   +2 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source