Results 21 to 30 of about 1,905,942 (404)

Impact of blinding on estimated treatment effects in randomised clinical trials: meta-epidemiological study

open access: yesBritish medical journal, 2020
Objectives To study the impact of blinding on estimated treatment effects, and their variation between trials; differentiating between blinding of patients, healthcare providers, and observers; detection bias and performance bias; and types of outcome ...
Helene Moustgaard   +12 more
semanticscholar   +1 more source

Paying clinicians to join clinical trials : a review of guidelines and interview study of trialists [PDF]

open access: yes, 2009
Background: The motivations of clinicians to participate in clinical trials have been little studied. This project explored the potential role of payment for participation in publicly funded clinical trials in the UK.
Association of British Pharmaceutical Industries   +23 more
core   +3 more sources

Biomolecular Prospecting, Informative Gaps, and the Cancer Clinic: A Qualitative Fieldwork and an Epistemological, Historical and Ethical Analysis of Informed Consent for Clinical Trials for Monoclonal Antibodies and Biobank Research

open access: yesFrontiers in Genetics, 2022
What happens to patients with cancer engaged in biomedical research when intellectual property regimes and ethical regimes intersect? This qualitative historical study addresses this question by situating the experiences, hopes, and reasons of patients ...
Flavio D’Abramo   +4 more
doaj   +1 more source

Global trends in clinical trials involving pluripotent stem cells: a systematic multi-database analysis

open access: yesnpj Regenerative Medicine, 2020
Pluripotent stem cells (PSCs) hold great potential for novel therapeutic approaches to regenerate or replace functionally impaired tissues. Since the introduction of the induced pluripotent stem cell technology in 2006, the number of scientific ...
J. Deinsberger, D. Reisinger, B. Weber
semanticscholar   +1 more source

Analyzing differences in the costs of treatment across centers within economic evaluations [PDF]

open access: yes, 2001
Objectives: Assessments of health technologies increasingly include economic evaluations conducted alongside clinical trials. One particular concern with economic evaluations conducted alongside clinical trials is the generalizability of results from one
Coyle, D, Drummond, M F
core   +1 more source

Applications of Blockchain Technology in Clinical Trials: Review and Open Challenges

open access: yesThe Arabian journal for science and engineering, 2020
Blockchain technology has disclosed unprecedented opportunities in the healthcare sector by unlocking the true value of interoperability. Specifically, the striking features of blockchain technology, such as data provenance, transparency, decentralized ...
Ilhaam A. Omar   +4 more
semanticscholar   +1 more source

A Clinical Trial Design for Evaluating Topical Antimicrobials in Chronic Wounds: The BLEU Trial

open access: yesLife, 2023
Chronic wound management is a global challenge. Millions of patients suffer from nonhealing ulcers and health systems are overwhelmed by the growing demand for treatment. Despite the prevalence of chronic wounds, the emergence of wound centers and specialized physicians is a recent phenomenon.
Thomas Serena   +3 more
openaire   +3 more sources

ASTRO Journals' Data Sharing Policy and Recommended Best Practices. [PDF]

open access: yes, 2019
Transparency, openness, and reproducibility are important characteristics in scientific publishing. Although many researchers embrace these characteristics, data sharing has yet to become common practice.
Braverman, Lisa   +8 more
core   +2 more sources

Can real-world data really replace randomised clinical trials?

open access: yesBMC Medicine, 2020
Background Classically, randomised controlled trials (RCTs) are considered the gold standard for demonstrating product efficacy for the regulatory approval of medicines.
S. Ramagopalan, A. Simpson, C. Sammon
semanticscholar   +1 more source

Occipital nerve stimulation for headache disorders [PDF]

open access: yes, 2010
Occipital nerve stimulation (ONS) was originally described in the treatment of occipital neuralgia. However, the spectrum of possible indications has expanded in recent years to include primary headache disorders, such as migraine and cluster headaches ...
Bartsch, Thorsten, Paemeleire, Koen
core   +2 more sources

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