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The Bayesian Design of Adaptive Clinical Trials
International Journal of Environmental Research and Public Health, 2021 This paper presents a brief overview of the recent literature on adaptive design of clinical trials from a Bayesian perspective for statistically not so sophisticated readers. Adaptive designs are attracting a keen interest in several disciplines, from a
A. Giovagnoli
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Clinical Orthopaedics and Related Research, 2021 Background A lack of racial and ethnic representation in clinical trials may limit the generalizability of the orthopaedic evidence base as it applies to patients in underrepresented minority populations and perpetuate existing disparities in use ...
T. Cwalina +4 more
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Molecular targets and gene therapy of lung cancer [PDF]
Archive of Oncology, 2009 Lung cancer is of great interest in human pathology because its apparent aggressiveness cannot be stopped by applied treatment procedures. The lack of highly specific screening tests prevents an early diagnosis of the disease.
Vasić Ljiljana
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International Brazilian Journal of Urology, 2022 Introduction: We aimed to evaluate the role of remote proctoring during the initial training phases of a robotics curriculum using surgical robot skills simulator exercises.
Arie Carneiro +6 more
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Profile of clinical research related to orthopedic disorders in the last five years
Journal of the Foot & Ankle, 2022 Objective: The aim of the study was to identify the profile of clinical research related to orthopedic disorders worldwide. Methods: A survey of clinical research in orthopedics was performed in the ClinicalTrials.gov platform and Plataforma Brasil ...
Luis Lopez Martinez +5 more
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SPOT: Sequential Predictive Modeling of Clinical Trial Outcome with Meta-Learning [PDF]
ACM International Conference on Bioinformatics, Computational Biology and Biomedicine, 2023 Clinical trials are essential to drug development but time-consuming, costly, and prone to failure. Accurate trial outcome prediction based on historical trial data promises better trial investment decisions and more trial success. Existing trial outcome
Zifeng Wang, Cao Xiao, Jimeng Sun
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British medical journal, 2020 Objectives To study the impact of blinding on estimated treatment effects, and their variation between trials; differentiating between blinding of patients, healthcare providers, and observers; detection bias and performance bias; and types of outcome ...
Helene Moustgaard +12 more
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Frontiers in Genetics, 2022 What happens to patients with cancer engaged in biomedical research when intellectual property regimes and ethical regimes intersect? This qualitative historical study addresses this question by situating the experiences, hopes, and reasons of patients ...
Flavio D’Abramo +4 more
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npj Regenerative Medicine, 2020 Pluripotent stem cells (PSCs) hold great potential for novel therapeutic approaches to regenerate or replace functionally impaired tissues. Since the introduction of the induced pluripotent stem cell technology in 2006, the number of scientific ...
J. Deinsberger, D. Reisinger, B. Weber
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A Clinical Trial Design for Evaluating Topical Antimicrobials in Chronic Wounds: The BLEU Trial
Life, 2023 Chronic wound management is a global challenge. Millions of patients suffer from nonhealing ulcers and health systems are overwhelmed by the growing demand for treatment. Despite the prevalence of chronic wounds, the emergence of wound centers and specialized physicians is a recent phenomenon.
Thomas Serena +3 more
openaire +3 more sources