Results 21 to 30 of about 332,732 (168)

Knowledge and Attitudes Towards Clinical Trial Participation in Oman: A cross-sectional study

Sultan Qaboos University Medical Journal, 2018
Objectives: Clinical trials are prospective studies on human subjects designed to answer various clinical questions. However, only a limited number of clinical trials have been conducted in Oman.
Hussain Al-Lawati, Khalid Al-Baimani, Mahra Al-Zadjali, Nasra Al-Obaidani, Ziyana Al-Kiyumi, Murtadha K. Al-Khabori   +5 more
doaj   +1 more source

Clinical Trials in Portugal: Past and Future. Position Paper from the Colleges of Clinical Pharmacology and Pharmaceutical Medicine

Acta Médica Portuguesa
N/a.
Filipa Borges-Carneiro, Miguel Torre Souto, Isabel Silva, Paula Leão Moreira, Paula Ferraz de Oliveira, Diogo José Lopes, Luís Figueira, Marta Reina-Couto, Luís Cunha-Miranda, Diogo Ponces Bento, Fernando Magro   +10 more
doaj   +1 more source

The Cricothyroid versus Spray-As-You-Go Method for Topical Anesthesia during Flexible Bronchoscopy: The CRISP Randomized Clinical Trial

Respiration, 2019
<b><i>Background:</i></b> Comparative characteristics of the cricothyroid injection and spray-as-you-go methods for lidocaine administration during diagnostic flexible bronchoscopy are not clear. <b><i>Objectives:</i></b> Co-primary outcomes were comparison of cough count from bronchoscope introduction ...
Karan Madan, Saurabh Mittal, Nishkarsh Gupta, Shiba Kalyan Biswal, Pawan Tiwari, Vijay Hadda, Anant Mohan, Randeep Guleria   +7 more
openaire   +5 more sources

Novel trial designs: Master protocol trials

Perspectives in Clinical Research
Conventional trial designs are resource and time-intensive. To accelerate the process of testing new interventions, we now have several novel research trial designs.
Priya Ranganathan, Vishal Deo, C. S. Pramesh, Mahesh P. Parmar   +3 more
doaj   +1 more source

Asking new questions with old data: The Centralized Open-Access Rehabilitation database for Stroke (SCOAR).

Frontiers in Neurology, 2016
Background: This paper introduces a tool for streamlining data integration in rehabilitation science, the Centralized Open-Access Rehabilitation database for Stroke (SCOAR), which allows researchers to quickly visualize relationships among variables ...
Keith Lohse, Sydney Y Schaefer, Sydney Y Schaefer, Adam Raikes, Lara Boyd, Catherine E Lang   +5 more
doaj   +1 more source

Targeting mTOR in Pancreatic Ductal Adenocarcinoma

Frontiers in Oncology, 2016
Treatment options for advanced pancreatic ductal adenocarcinoma (PDAC) are limited, however, new therapies targeting specific tumor-related molecular characteristics may help certain patient cohorts. Emerging preclinical data has shown that inhibition of
Sentia eIriana, Shahzad eAhmed, Jun eGong, Jun eGong, Alagappan Anand Annamalai, Richard eTuli, Andrew Eugene Hendifar   +6 more
doaj   +1 more source

Inadequate reporting quality of registered genome editing trials: an observational study

BMC Medical Research Methodology, 2022
Background To assess registration completeness and safety data of trials on human genome editing (HGE) reported in primary registries and published in journals, as HGE has safety and ethical problems, including the risk of undesirable and unpredictable ...
Diana Jurić, Michael Zlatin, Ana Marušić   +2 more
doaj   +1 more source

Exosomes and Immune Response in Cancer: Friends or Foes?

Frontiers in Immunology, 2018
Exosomes are a type of extracellular vesicle whose study has grown exponentially in recent years. This led to the understanding that these structures, far from being inert waste by-products of cellular functioning, are active players in intercellular ...
Francisco M. Barros, Fatima Carneiro, Fatima Carneiro, Fatima Carneiro, Fatima Carneiro, Jose C. Machado, Jose C. Machado, Jose C. Machado, Sónia A. Melo, Sónia A. Melo, Sónia A. Melo   +10 more
doaj   +1 more source

An alternative approach to deal with the absence of clinical trials: a proportional meta-analysis of case series studies [PDF]

Acta Cirúrgica Brasileira, 2013
PURPOSE: Systematic reviews are criticized for frequently offering inconsistent evidences and absence of straightforward recommendations. Their value seems to be depreciated when the conclusions are uncertain.
Regina El Dib, Paulo Nascimento Junior, Anil Kapoor   +2 more
doaj   +2 more sources

Topical isoniazid as a novel treatment for melasma: A randomized, double‐blind, vehicle‐controlled clinical trial

Journal of Cosmetic Dermatology
AbstractIntroductionMelasma is a chronic hyperpigmentation disorder, and its treatment poses a challenge to dermatologists due to its chronicity and resistance to conventional therapies. Oral isoniazid is used for the treatment of tuberculosis. One of us had previously showed that topical isoniazid exerts a strong depigmenting action in animal models ...
Najmeh, Ahramiyanpour, Zahra, Mahmoudi, Nazanin Zeinali, Nezhad, Payam, Khazaeli, Rezvan, Amiri, Behrooz, Kasraee   +5 more
openaire   +2 more sources