Results 71 to 80 of about 1,905,942 (404)

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

An alternative approach to deal with the absence of clinical trials: a proportional meta-analysis of case series studies [PDF]

Acta Cirúrgica Brasileira, 2013
PURPOSE: Systematic reviews are criticized for frequently offering inconsistent evidences and absence of straightforward recommendations. Their value seems to be depreciated when the conclusions are uncertain.
Regina El Dib, Paulo Nascimento Junior, Anil Kapoor   +2 more
doaj   +2 more sources

Trustworthiness of Patient-Reported Outcomes in Unblinded Cancer Clinical Trials.

JAMA Oncology, 2017
There is substantial and growing interest in measuring patient-reported outcomes in drug development trials, 1 for example, to understand the effects of treatment on tumor-associated pain.
T. Atkinson, J. Wagner, E. Basch
semanticscholar   +1 more source

Double-blind clinical trial of topical steroids in anterior uveitis. [PDF]

British Journal of Ophthalmology, 1979
We present the results of a double-blind trial comparing the efficacy of betamethasone phosphate 0.1%, clobetasone butyrate 0.1%, and placebo in the treatment of acute unilateral nongranulomatous uveitis. The 2 steroids were equally comparable in improvement of the patients' symptoms, though betamethasone phosphate was significantly more effective than
J A Dunne, J P Travers
openaire   +3 more sources

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Evaluation of sodium nitroprusside for controlled hypotension in children during surgery

Frontiers in Pharmacology, 2015
Purpose. (1) To define the onset and offset of the blood-pressure-lowering effects of sodium nitroprusside (SNP) for use in developing instructions for dose titration in children undergoing a surgical or medical procedure, and (2) to assess the safety of
David R Drover, Gregory B Hammer, Jeffrey Scott Barrett, Carol A Cohane, Tammy eReece, Anne eZajicek, Scott eSchulman, Scott eSchulman   +7 more
doaj   +1 more source

ITTC @ TREC 2021 Clinical Trials Track [PDF]

arXiv, 2022
This paper describes the submissions of the Natural Language Processing (NLP) team from the Australian Research Council Industrial Transformation Training Centre (ITTC) for Cognitive Computing in Medical Technologies to the TREC 2021 Clinical Trials Track.
arxiv  

Regenerative medicine: Stroke survivor and carer views and motivations towards a proposed stem cell clinical trial using placebo neurosurgery [PDF]

, 2018
Background  Few studies explore stroke survivor views and motivations towards stem cell therapy (SCT). This qualitative study explores the views and motivations of both stroke survivors and their partners/carers towards a proposed 2-arm Phase III ...
Abhyankar, Abhyankar, Abhyankar, Aked, Akinsanya, Alaszewski, Alfred, Anderson, Bekker, Bell, Bowling, Braun, Brown, Campbell, Connell, Coolbrandt, Dekkers, Dixon-Woods, Donovan, Donovan, Donovan, Donovan, Entwhistle, Exel, Gillies, Goetz, Greenwood, Guba, Guest, Illingworth, Juraskova, King, Knebly, Lidz, Liu, Lo, Luker, Madse, McCann, McDonald, Miles, Mills, Moorcraft, Paolucci, Rigby, Ritchie, Robinson, Sagi, Savitz, Secrest, Sinden, Singer, Stroke Association, Swift, Treweek, Welton, West, World Medical Association   +57 more
core   +2 more sources

Continuous Positive Airway Pressure Treatment in Patients with Alzheimer's Disease: A Systematic Review [PDF]

, 2020
Background: Epidemiological studies have suggested a pathophysiological relationship between obstructive sleep apnea syndrome (OSAS) and Alzheimer's disease (AD).
Galán Mercant, Alejandro, González Medina, Gloria, Jimenez-Rejano, Jose Jesus, Martin-Valero, Rocio, Pérez Cabezas, Verónica, Ruiz Molinero, María del Carmen   +5 more
core   +2 more sources

The solution supramolecular structure of α2 → 8 polysialic acid suggests a structural cause for its low immunogenicity

FEBS Letters, EarlyView.
α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley   +1 more source