Results 1 to 10 of about 1,898 (135)

Intra-articular injection of clioquinol ameliorates osteoarthritis in a rabbit model [PDF]

Frontiers in Medicine, 2022
Osteoarthritis (OA) is characterized by the degeneration of articular cartilage. Decreased autophagy is tightly associated with chondrocyte death, which contributes to the progression of OA.
Xiaoqing Wu, Xiaoqing Wu, Peng Xu, Xuanren Shi, Jian Shang, Xiaoyong Chen, Anyun Guo, Fuming Wang, Zhanhai Yin   +8 more
doaj   +2 more sources

Broad susceptibility of Candida auris strains to 8-hydroxyquinolines and mechanisms of resistance [PDF]

mBio, 2023
The fungal pathogen Candida auris represents a severe threat to hospitalized patients. Its resistance to multiple classes of antifungal drugs and ability to spread and resist decontamination in healthcare settings make it especially dangerous.
Matthew B. Lohse, Matthew T. Laurie, Sophia Levan, Naomi Ziv, Craig L. Ennis, Clarissa J. Nobile, Joseph DeRisi, Alexander D. Johnson   +7 more
doaj   +2 more sources

Effects of orally administered clioquinol on the fecal microbiome of horses [PDF]

Journal of Veterinary Internal Medicine
Background Whereas restoration of fecal consistency after treatment with clioquinol for chronic diarrhea and free fecal water syndrome has been attributed to its antiprotozoal properties, actions of clioquinol on the colonic bacterial microbiota have not
Mikaila Z. Smith, Mary York, Kile S. Townsend, Lynn M. Martin, Tamara Gull, Lyndon M. Coghill, Aaron C. Ericsson, Philip J. Johnson   +7 more
doaj   +2 more sources

Development of a Clioquinol Nanocarrier as a New, Promising Option for the Treatment of Dermatomycosis [PDF]

Pharmaceutics, 2023
Dermatomycosis is a common fungal infection, and its treatment is limited by few antifungal agents. Clioquinol (CQ) is an antiparasitic agent that has been studied for new uses, such as antifungal and antiviral applications.
Simone Jacobus Berlitz, Paula Reginatto, Gabriella da Rosa Monte Machado, Alexandre Meneghello Fuentefria, Fernando Dal Pont Morisso, Renata Vidor Contri, Irene Clemes Külkamp-Guerreiro   +6 more
doaj   +2 more sources

NQO1 protects against clioquinol toxicity

Frontiers in Pharmacology, 2022
Clioquinol (CQ) was widely used as oral antibiotic before being taken off the market in many countries in 1970, after it was linked to subacute myelo-optic neuropathy (SMON) in Japan, leading to vision loss with many patients left wheelchair-bound.
Jamuna Chhetri, Jem Dilek, Noel Davies, Glenn Jacobson, Robert Dallmann, Nuri Gueven   +5 more
doaj   +3 more sources

Protective effect of zinc against A2E-induced toxicity in ARPE-19 cells: Possible involvement of lysosomal acidification [PDF]

Heliyon
A key pathogenic mechanism of dry age-related macular degeneration (AMD) is lysosomal dysfunction in retinal pigment epithelium (RPE) cells, which results in the accumulation of lipofuscins such as A2E (N-retinylidene-N-retinylethanolamine) that further ...
Jeong A. Choi, Bo-Ra Seo, Jae-Young Koh, Young Hee Yoon   +3 more
doaj   +2 more sources

Amphetamine-like Deferiprone and Clioquinol Derivatives as Iron Chelating Agents [PDF]

Molecules
The accumulation of iron in dopaminergic neurons can cause oxidative stress and dopaminergic neuron degeneration. Iron chelation therapy may reduce dopaminergic neurodegeneration, but chelators should be targeted towards dopaminergic cells. In this work,
Mahmoud El Safadi, Katie A. Wilson, Indigo J. Strudwicke, Megan L. O’Mara, Mohan Bhadbhade, Tristan Rawling, Andrew M. McDonagh   +6 more
doaj   +2 more sources

New applications of clioquinol in the treatment of inflammation disease by directly targeting arginine 335 of NLRP3 [PDF]

Journal of Pharmaceutical Analysis
The NOD-like receptor protein 3 (NLRP3) inflammasome is essential in innate immune-mediated inflammation, with its overactivation implicated in various autoinflammatory, metabolic, and neurodegenerative diseases.
Peipei Chen, Yunshu Wang, Huaiping Tang, Chao Zhou, Zhuo Liu, Shenghan Gao, Tingting Wang, Yun Xu, Sen-Lin Ji   +8 more
doaj   +2 more sources

Zinc dampens antitumor immunity by promoting Foxp3+ regulatory T cells [PDF]

Frontiers in Immunology
IntroductionThe role of zinc (Zn) in tumor development and immune modulation has always been paradoxical. This study redefines our understanding of the impact of Zn on cancer progression and therapeutic strategies.MethodsWe investigated the effects of ...
Sugandha Narayan, Rajdeep Dalal, Zaigham Abbas Rizvi, Zaigham Abbas Rizvi, Amit Awasthi, Amit Awasthi   +5 more
doaj   +2 more sources

Estrogen-related receptor alpha (ERRα) controls the stemness and cellular energetics of prostate cancer cells via its direct regulation of citrate metabolism and zinc transportation [PDF]

Cell Death and Disease
Compared to most tumors that are more glycolytic, primary prostate cancer is less glycolytic but more dependent on TCA cycle coupled with OXPHOS for its energy demand. This unique metabolic energetic feature is attributed to activation of mitochondrial m-
Taiyang Ma, Wenjuan Xie, Zhenyu Xu, Weijie Gao, Jianfu Zhou, Yuliang Wang, Franky Leung Chan   +6 more
doaj   +2 more sources