Results 41 to 50 of about 3,979 (194)

Review on analytical studies of some pharmaceutical compounds containing heterocyclic rings: brinzolamide, timolol maleate, flumethasone pivalate, and clioquinol

Future Journal of Pharmaceutical Sciences, 2020
Background The heterocyclic compounds are extremely important with wide array of synthetic, pharmaceutical, and industrial applications. Heterocyclic-containing compounds have been reported for their broad spectrum of biological activities including ...
Asmaa A. Mandour, Nada Nabil, Hala E. Zaazaa, Mohamed Abdelkawy   +3 more
doaj   +1 more source

Nanoscale Reaction Vessels Designed for Synthesis of Copper-Drug Complexes Suitable for Preclinical Development. [PDF]

PLoS ONE, 2016
The development of copper-drug complexes (CDCs) is hindered due to their very poor aqueous solubility. Diethyldithiocarbamate (DDC) is the primary metabolite of disulfiram, an approved drug for alcoholism that is being repurposed for cancer.
Mohamed Wehbe, Malathi Anantha, Ian Backstrom, Ada Leung, Kent Chen, Armaan Malhotra, Katarina Edwards, Marcel B Bally   +7 more
doaj   +1 more source

Discovery of Clioquinol and analogues as novel inhibitors of Severe Acute Respiratory Syndrome Coronavirus 2 infection, ACE2 and ACE2 - Spike protein interaction in vitro

Heliyon, 2021
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiological agent for coronavirus disease 2019 (COVID-19), has resulted in an ongoing pandemic. Presently, there are no clinically approved drugs for COVID-19.
Omonike A. Olaleye, Manvir Kaur, Collins Onyenaka, Tolulope Adebusuyi   +3 more
doaj   +1 more source

PIK‐III‐Mediated Elevation of Thiamine Re‐Sensitises Renal Cell Carcinoma to Cuproptosis via Activating PDHA1

Cell Proliferation, Volume 59, Issue 3, March 2026.
PIK‐III enhancing the efficacy of cuproptosis to kill renal cancer cells through dysregulating thiamine metabolism and dephosphorylation of pyruvate dehydrogenase complex E1 (PDHA1), providing a potential option for treatment of cuproptosis‐resistant renal cancer by the combination of PIK‐III and elesclomol.
Dongdong Xie, Yu Wang, Wenjie Cheng, Minbo Yan, Kunyu Li, Xiang Wu, Jiaqing Wu, Zhuangzhuang Zhang, Yingbo Dai   +8 more
wiley   +1 more source

Clioquinol synergistically augments rescue by zinc supplementation in a mouse model of acrodermatitis enteropathica. [PDF]

PLoS ONE, 2013
BackgroundZinc deficiency due to poor nutrition or genetic mutations in zinc transporters is a global health problem and approaches to providing effective dietary zinc supplementation while avoiding potential toxic side effects are needed.Methods ...
Jim Geiser, Robert C De Lisle, David Finkelstein, Paul A Adlard, Ashley I Bush, Glen K Andrews   +5 more
doaj   +1 more source

Isolation and Characterisation of Serotype III in Miamiensis avidus (Ciliophora: Scuticociliatida) From Olive Flounder (Paralichthys olivaceus)

Journal of Fish Diseases, Volume 49, Issue 2, February 2026.
ABSTRACT Miamiensis avidus (Ciliophora: Scuticociliatida, syn. Philasterides dicentrarchi) is a significant pathogen causing scuticociliatosis in olive flounder (Paralichthys olivaceus) in Korea and Japan. In this study, the BB19 strain, isolated from olive flounder, was identified as M.
Jin‐Young Kim, Jeong‐Hoon Kim, Su‐Mi Shin, Taeho Kim, Se Ryun Kwon, Sung‐Ju Jung   +5 more
wiley   +1 more source

β-Amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase [PDF]

, 2004
β-Amyloid (βA) peptide is strongly implicated in the neurodegeneration underlying Alzheimer's disease, but the mechanisms of neurotoxicity remain controversial. This study establishes a central role for oxidative stress by the activation of NADPH oxidase
Abramov, A.Y., Canevari, L., Duchen, M.R.   +2 more
core  

From Yeast to Therapeutics: Modeling Neurodegenerative Diseases in Saccharomyces cerevisiae

Yeast, Volume 42, Issue 12, Page 283-302, December 2025.
Yeast plasmids expressing human Aβ‐42, α‐syn, htt, and TDP‐43. Their fate includes an equilibrium between the endocytic pathway and aggregates that potentially disrupt endocytosis, vesicular transport, vacuolar autophagy, and mitochondrial activity. ABSTRACT Here, we review the use of Saccharomyces cerevisiae as a powerful model organism for studying ...
Jose Ribamar Ferreira‐Junior, Vittoria de Lima Camandona, Mario H. Barros   +2 more
wiley   +1 more source

Monitoring Receptor Clustering by Aggregation‐Induced Emission

ChemPlusChem, Volume 90, Issue 11, November 10, 2025.
Receptor clustering induced by molecular recognition: AIE‐functionalized bisphosphonate receptors are embedded in a lipid bilayer. Upon addition of a cationic messenger, they undergo dimerization and send out a fluorescence signal. This study introduces a simple signal transduction system that mimics the receptor tyrosine kinase mechanism by employing ...
Robert Bekus, Kevin Rudolph, Steffen Riebe, Jens Voskuhl, Thomas Schrader   +4 more
wiley   +1 more source

Mechanochemische Methoden mit Anwendung in der Late‐Stage Modifizierung Pharmazeutisch Wirksamer Verbindungen

Angewandte Chemie, Volume 137, Issue 41, October 6, 2025.
Dieser Review diskutiert mechanochemische Strategien zur späten Modifizierung bioaktiver Wirkstoffe und bietet zugleich eine wertvolle Übersicht zur Auswahl geeigneter Substrate, um das pharmazeutische Potenzial neuer und bestehender (mechano)chemischer Verfahren zu evaluieren.
Johanna Templ, Lars Borchardt
wiley   +1 more source