Results 51 to 60 of about 3,979 (194)

Nanoparticles as potential clinical therapeutic agents in Alzheimer’s disease: focus on selenium nanoparticles [PDF]

, 2017
In etiology of Alzheimer’s disease (AD), involvement of amyloid β (Aβ) plaque accumulation and oxidative stress in the brain have important roles.
Muhamad, Salina, Nazıroğlu, Mustafa, Pecze, Laszlo   +2 more
core   +1 more source

Diclofenac impairs autophagic flux via oxidative stress and lysosomal dysfunction: Implications for hepatotoxicity

Redox Biology, 2020
Treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with various side effects, including cardiovascular and hepatic disorders. Studies suggest that mitochondrial damage and oxidative stress are important mediators of toxicity, yet ...
Seung-Hwan Jung, Wonseok Lee, Seung-Hyun Park, Kang-Yo Lee, You-Jin Choi, Soohee Choi, Dongmin Kang, Sinri Kim, Tong-Shin Chang, Soon-Sun Hong, Byung-Hoon Lee   +10 more
doaj   +1 more source

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

Angewandte Chemie International Edition, Volume 64, Issue 41, October 6, 2025.
This review highlights mechanochemical strategies for the late‐stage modification of active pharmaceutical ingredients (APIs), providing a valuable resource for selecting substrates to evaluate the pharmaceutical potential of novel and existing (mechano)chemical protocols.
Johanna Templ, Lars Borchardt
wiley   +1 more source

Clioquinol derivatives as potent inhibitors of Methicillin-Resistant Staphylococcus aureus and their mechanistic study

Results in Chemistry
Aims: Methicillin-Resistant Staphylococcus aureus cause many nosocomial, and community-acquired infections, burdening healthcare systems globally. The aim of the current study was to identify the potent inhibitors of MRSA strains as first step towards ...
Sumaira Hamid, Atia-tul-Wahab, Shoukat Wali, Humaira Zafar, M. Iqbal Choudhary   +4 more
doaj   +1 more source

Clioquinol rescues Parkinsonism and dementia phenotypes of the tau knockout mouse

Neurobiology of Disease, 2015
Iron accumulation and tau protein deposition are pathological features of Alzheimer's (AD) and Parkinson's diseases (PD). Soluble tau protein is lower in affected regions of these diseases, and we previously reported that tau knockout mice display motor ...
Peng Lei, Scott Ayton, Ambili Thoppuvalappil Appukuttan, Irene Volitakis, Paul A. Adlard, David I. Finkelstein, Ashley I. Bush   +6 more
doaj   +1 more source

Clioquinol inhibits zinc-triggered caspase activation in the hippocampal CA1 region of a global ischemic gerbil model. [PDF]

PLoS ONE, 2010
BACKGROUND: Excessive release of chelatable zinc from excitatory synaptic vesicles is involved in the pathogenesis of selective neuronal cell death following transient forebrain ischemia.
Tao Wang, Wei Zheng, He Xu, Jia-Min Zhou, Zhan-You Wang   +4 more
doaj   +1 more source

Synthesis, Properties, and Typical Applications of MXene‐Based Heterostructure Materials

Advanced Materials Interfaces, Volume 12, Issue 19, October 6, 2025.
In recent years, MXene‐based heterostructure materials have achieved fruitful outcomes in multiple aspects. However, a comprehensive and systematic summary of MXene‐based heterostructures is still absent. This review summarizes the performance characteristics, synthesis methods, and the latest research progress of MXene heterostructures in several ...
Baoquan Xiao, Zelin Gao, Hengbiao Zhang, Jiantao Zhang, Shiyuan Wang, Gang Long, Shenghu Wei, Jixing Huang, Runqi Yao, Xingdong Jiang, Fei Ma, Xusheng Xia, Liyun Ding   +12 more
wiley   +1 more source

Pre-Clinical Pharmacokinetics, Tissue Distribution and Physicochemical Studies of CLBQ14, a Novel Methionine Aminopeptidase Inhibitor for the Treatment of Infectious Diseases

Drug Design, Development and Therapy, 2020
Oscar Ekpenyong, Xiuqing Gao, Jing Ma, Candace Cooper, Linh Nguyen, Omonike A Olaleye, Dong Liang, Huan Xie Department of Pharmaceutical and Environmental Health Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX ...
Ekpenyong O, Gao X, Ma J, Cooper C, Nguyen L, Olaleye OA, Liang D, Xie H   +7 more
doaj  

Restoration of susceptibility to amikacin by 8-hydroxyquinoline analogs complexed to zinc.

PLoS ONE, 2019
Gram-negative pathogens resistant to amikacin and other aminoglycosides of clinical relevance usually harbor the 6'-N-acetyltransferase type Ib [AAC(6')-Ib], an enzyme that catalyzes inactivation of the antibiotic by acetylation using acetyl-CoA as donor
Jesus Magallon, Kevin Chiem, Tung Tran, Maria S Ramirez, Veronica Jimenez, Marcelo E Tolmasky   +5 more
doaj   +1 more source

Quantitative analysis of mixed lipid nanostructures in rat skin by HPLC-MS

Reviews in Analytical Chemistry
Liquid chromatography-mass spectrometry (LC-MS) is a very sensitive technique for determining small concentrations of drugs in fixed dose combinations or even those deposited in skin layers.
Al-Tannak Naser F., Abouelatta Samar M., Fahmy Nesma M., Hemdan Ahmed M.   +3 more
doaj   +1 more source