Results 111 to 120 of about 2,071 (187)
Journal of Chemical ResearchCDC2-like kinase 2 is a promising target for the therapy of knee osteoarthritis. A series of natural and commercial triterpenoid derivatives were evaluated for their inhibitory activity against CDC2-like kinase 2 using ADP-Glo assay by GloMax ® Navigator
Xiaozhe Zhang +3 more
doaj +1 more source
Correlation between splicing activity and cell growth by CLK1 and CLK2.
, 2015 (A) Scatter plots comparing in vitro kinase inhibition with cellular splicing alteration of S6K after treatment with Cpd-1, Cpd-2, Cpd-3, and a series of other compounds.
Risa Miyashita (683052) +7 more
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Oil Red O staining of 3T3-L1 cells after day 6 of transfection with Clk1 mutants.
, 2013 3T3-L1 cells were grown on 35 mm dishes and transfected with Clk1 mutants as labeled. Following 6 days of the differentiation procedure for adipogenesis, cells were stained with Oil Red O as described in Methods and brightfield microscopy revealed the ...
Jacqueline Romero (290584) +6 more
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, 2013 3T3-L1 cells were transfected with Clk1-AAA cDNA or control plasmid and then exposed to differentiation conditions for 4 days prior to fixation and staining with DAPI or conjugated SFSR5 (or SRp40) or PSF antibodies for fluorescence microscopy ...
Jacqueline Romero (290584) +6 more
core +1 more source
Experimental and Molecular MedicineCurrent treatment strategies for medulloblastoma remain ineffective owing to extensive tumor heterogeneity. We generated five platforms of omics data including liquid chromatography and mass spectrometry-based proteome and performed integrated multi-omic
Seong-Min Park +37 more
doaj +1 more source
, 2019 (A) The distribution of SRSF2 (red, detected by immunofluorescence) in cells transfected with the normal or mutant Clk1 kinase tagged with Cerulean (cyan). DIC in grey. Bar = 5 μm.
Shani Nadav-Eliyahu (8039129) +5 more
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Design and synthesis of dual inhibitors of DYRK1A and CLK1, kinases involved in Alzheimer's disease
, 2021 La maladie d’Alzheimer est la forme de démence la plus répandue dans le monde et à ce jour, aucun traitement efficace n’existe malgré de nombreuses recherches en cours.
Pescheteau, Clémentine
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Supplementary Figure S20 from CLK1 Activates YAP to Promote Intrahepatic Cholangiocarcinogenesis
<p>Supplementary Figure S20</p>
Haichuan Wang +12 more
openaire +1 more source
Development of new lead-like dual inhibitors of the cdc2-like kinase 1 (Clk1) and dual specificity Y-phosphorylation regulated kinases 1A and 1B (Dyrk1A and Dyrk1B) [PDF]
, 2014 Dyrk1A, a kinase from the CMGC group of kinases was recently identified as potential drug target for the treatment of Down Syndrome (DS) related Alzheimer’s Disease.
Schmitt, Christian
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