Results 91 to 100 of about 2,071 (187)

Clk1 overexpression does not prevent the recruitment of splicing factors to the transcription site and increases their intra-nuclear dynamics.

, 2019
(A) Nuclear speckles observed by SRSF7-GFP (green) begin to disperse as RFP-Clk1 (magenta) expression increases. Frames from S1 Movie. (B) The number of nuclear speckles was counted in untreated cells, in Clk1 overexpressing and TNPO3 overexpressing ...
Shani Nadav-Eliyahu (8039129), Yehuda Brody (233326), Yaron Shav-Tal (105312), Rakefet Ben-Yishay (8039132), Hodaya Hochberg-Laufer (8039126), Noa Neufeld (233329)   +5 more
core   +1 more source

Molecular subtyping and precision therapy for esophageal cancer

Interdisciplinary Medicine, Volume 3, Issue 3, May 2025.
The molecular typing of esophageal cancer based on genome, transcriptome, proteome, and multi‐omics revealed various molecular features and provided potential targets for the precision therapy. Recent trials have shown that immunotherapy or molecular targeted therapy plus chemoradiotherapy can improve overall survival and progression‐free survival in ...
Guangkun Pei, Zhuoran Liang, Bianli Gu, Linlin Shi, Ze‐Xian Liu, Shegan Gao   +5 more
wiley   +1 more source

Clk1 overexpression does not inhibit splicing.

, 2019
(A) Recovery curves of the YFP-MS2 mRNA FRAP measurements performed on the E3 and E6 transcription sites under normal conditions and after treatment with the splicing inhibitor Pladienolide B.
Shani Nadav-Eliyahu (8039129), Yehuda Brody (233326), Yaron Shav-Tal (105312), Rakefet Ben-Yishay (8039132), Hodaya Hochberg-Laufer (8039126), Noa Neufeld (233329)   +5 more
core   +1 more source

Combined analysis of a serum mRNA/miRNA marker signature and CA 19‐9 for timely and accurate diagnosis of recurrence after resection of pancreatic ductal adenocarcinoma: A prospective multicenter cohort study

United European Gastroenterology Journal, Volume 13, Issue 3, Page 353-363, April 2025.
Abstract Background and Aims Timely and accurate detection of tumor recurrence in pancreatic ductal adenocarcinoma (PDAC) patients is an urgent and unmet medical need. This study aimed to develop a noninvasive molecular diagnostic procedure for the detection of recurrence after PDAC resection based on quantification of circulating mRNA and miRNA ...
Malte Buchholz, Ludwig Lausser, Miriam Schenk, Julie Earl, Rita T. Lawlor, Aldo Scarpa, Alfonso Sanjuanbenito, Alfredo Carrato, Nuria Malats, Christine Tjaden, Nathalia A. Giese, Markus Büchler, Thilo Hackert, Hans A. Kestler, Thomas M. Gress, for the BioPaC consortium   +15 more
wiley   +1 more source

clk1, a Serine/Threonine Protein Kinase-Encoding Gene, Is Involved in Pathogenicity of Colletotrichum lindemuthianum on Common Bean

Molecular Plant-Microbe Interactions, 1998
A random insertional mutagenesis in Colletotrichum lindemuthianum, the causal agent of common bean anthracnose, generated four mutants that showed altered pathogenicity when tested on intact seedlings, excised leaves, and/or excised hypocotyls.
Marie Dufresne, John A. Bailey, Michel Dron, Thierry Langin   +3 more
doaj   +1 more source

Identification of novel alternative splicing isoform biomarkers and their association with overall survival in colorectal cancer

BMC Gastroenterology, 2020
Background Alternative splicing (AS) is an important mechanism of regulating eukaryotic gene expression. Understanding the most common AS events in colorectal cancer (CRC) will help developing diagnostic, prognostic or therapeutic tools in CRC.
Haifeng Lian, Aili Wang, Yuanyuan Shen, Qian Wang, Zhenru Zhou, Ranran Zhang, Kun Li, Chengxia Liu, Hongtao Jia   +8 more
doaj   +1 more source

Stress-responsive maturation of Clk1/4 pre-mRNAs promotes phosphorylation of SR splicing factor

, 2011
It has been assumed that premessenger ribonucleic acids (RNAs; pre-mRNAs) are spliced cotranscriptionally in the process of gene expression. However, in this paper, we report that splicing of Clk1/4 mRNAs is suspended in tissues and cultured cells and ...
Masatoshi Hagiwara, Kensuke Ninomiya, Naoyuki Kataoka   +2 more
core   +1 more source

Chemical programming of kinase inhibitors in a modular chemputer-based system

Communications Biology
Manual synthesis of small molecules can represent a rate-limiting step in medicinal chemistry. This study describes the application of an automated, modular synthesis platform (‘Chemputer’) to a drug discovery project targeting a model of KRAS-mutant ...
Hammed A. Badmos, Petrisor-Alin Pirvan, Elena Klimareva, Leroy Cronin, Ross Cagan   +4 more
doaj   +1 more source

CL-L1 and CL-K1 Exhibit Widespread Tissue Distribution With High and Co-Localized Expression in Secretory Epithelia and Mucosa

Frontiers in Immunology, 2018
Collectin liver 1 (CL-L1, alias collectin 10) and collectin kidney 1 (CL-K1, alias collectin 11) are oligomeric pattern recognition molecules associated with the complement system, and mutations in either of their genes may lead to deficiency and ...
Soren W. K. Hansen, Josephine B. Aagaard, Karen B. Bjerrum, Eva K. Hejbøl, Ole Nielsen, Henrik D. Schrøder, Karsten Skjoedt, Anna L. Sørensen, Jonas H. Graversen, Maiken L. Henriksen   +9 more
doaj   +1 more source

CLK1 and its Effects on Skin Stem Cell Differentiation

, 2010
The primary objective of this study was to determine the effects of CDC-like kinase 1 (CLK1) on differentiation of a telogen skin stem cell line as a follow-up study to Dr. Lyle's previous work on the differentiation of hair follicle cells.
Maurer, Jennifer Marie, Duffty, Shannon Margaret   +1 more
core