Results 81 to 90 of about 2,071 (187)
, 2021 The abnormality of RNA-binding proteins (RBPs) is closely related to the tumorigenesis and development of esophageal squamous cell carcinoma (ESCC), and has been an area of interest for research recently.
Xiong Chen (555744) +9 more
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Addiction Biology, Volume 30, Issue 8, August 2025.Treadmill exercise improved METH‐induced learning and memory impairment in mice.Transcriptome analysis revealed that exercise modulated key pathways including PI3K‐Akt, mTOR, and Wnt signaling. NFKBIA, CXCL12, and Vav3 were identified as potential mediators of the beneficial effects.
Qiuyue Huang +6 more
wiley +1 more source
A novel CLK1‐THRAP3‐PPARγ axis is involved in the regulation of insulin sensitivity
The FASEB Journal, 2020 Increasing energy expenditure by promoting “browning” in adipose tissues is a promising strategy to prevent obesity and associated diabetes. To explore potential targets of cold exposure, which induces energy expenditure, we performed phosphoproteomics profiling in brown adipose tissue of mice that were housed ...
Lin Chang +7 more
openaire +1 more source
A single biochemical activity underlies the pleiotropy of the aging-related protein CLK-1
Scientific Reports, 2017 The Caenorhabditis elegans clk-1 gene and the orthologous mouse gene Mclk1 encode a mitochondrial hydroxylase that is necessary for the biosynthesis of ubiquinone (UQ).
Ju-Ling Liu +3 more
doaj +1 more source
Splicing to keep splicing: A feedback system for cellular homeostasis and state transition
Clinical and Translational Medicine, Volume 15, Issue 6, June 2025.ABSTRACT Background Alternative splicing (AS) plays a crucial role in regulating gene expression and governing proteomic diversity by generating multiple protein isoforms from a single gene. Increasing evidence has highlighted the regulation for pre‐mRNA splicing of the splicing factors (SFs).
Zhonghao Guo +4 more
wiley +1 more source
Single Akt-site mutations on Clk1 dysregulate PKCβII and increase Akt phosphorylation of SRp40.
, 2013 A. 3T3-L1 cells were transfected with single mutant Clk1 constructs as indicated and PKCβII levels, phosphoAkt-substrate for SRp40 and SRp40 levels were probed as indicated in cell lysates collected from cells exposed to differentiation conditions.
Jacqueline Romero (290584) +6 more
core +1 more source
European Journal of Organic Chemistry, Volume 28, Issue 17, May 21, 2025.Syntheses of quinoline and quinoxaline derivatives fused with phosphacycles were developed from commercially available quinolin‐6‐amine and quinoxalin‐6‐amine. Abstract Despite their potential in areas such as medicinal chemistry and organic materials, scaffolds in which quinoline and quinoxaline are fused to phosphacycles such as 1,3‐oxaphosphole, 1,3‐
Mohamed Ali Dridi +9 more
wiley +1 more source
Marine Drugs, 2018 Alzheimer’s disease (AD) is becoming one of the most disturbing health and socioeconomic problems nowadays, as it is a neurodegenerative pathology with no treatment, which is expected to grow further due to population ageing.
Laura Llorach-Pares +3 more
doaj +1 more source
Advanced Science, Volume 12, Issue 19, May 22, 2025.Pancreatic cancer is a highly aggressive malignancy with limited treatment options. CLK4 regulates alternative splicing, contributing to cancer progression. This study establishes a computational model to identify CLK4 inhibitors, leading to compound 150441 (IC50: 21.4 nm).
Chun‐Lin Yang +13 more
wiley +1 more source
Characterisation of the murine CLK1 dual-specificity kinase.
, 1997 Murine Clk1 (also known as Sty) was identified as a dual-specificity kinase capable of phosphorylating serine, threonine and tyrosine residues when expressed in bacteria.
Duncan, Peter I.
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